A5053530367- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Animal Vocal Communication and Behavior
- Bat Biology and Ecology Studies
- Marine animal studies overview
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Animal Behavior and Reproduction
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Avian ecology and behavior
- Evolution and Paleontology Studies
- Animal Behavior and Welfare Studies
- Ion channel regulation and function
- Connexins and lens biology
- Asthma and respiratory diseases
- Mitochondrial Function and Pathology
- Sex and Gender in Healthcare
- Erythrocyte Function and Pathophysiology
- Multisensory perception and integration
- Ear Surgery and Otitis Media
Johns Hopkins University
2015-2025
Johns Hopkins Medicine
2015-2025
ORCID
2017
Walter Reed Army Institute of Research
2009
University of Maryland, College Park
2001-2008
Lateral olivocochlear (LOC) efferent neurons modulate auditory nerve fiber (ANF) activity using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine (ACh). Little is known about how individual neurotransmitter systems are differentially utilized in response to the ever-changing acoustic environment. Here we present quantitative evidence rodents that dopaminergic LOC input ANFs dynamically regulated according animal’s recent experience. Sound exposure upregulates...
Abstract Noise exposure is one of the most common causes hearing loss and peripheral damage to auditory system. A growing literature suggests that system can compensate for through increased central neural activity. The current study sought investigate link between noise exposure, increases in gain, synaptic reorganization, function. All axons nerve project cochlear nucleus, making it a requisite nucleus sound detection. As first synapse system, well positioned respond plastically input. To...
Sound processing in the cochlea is modulated by cholinergic efferent axons arising from medial olivocochlear neurons brainstem. These contact outer hair cells mature and inner during development activate nicotinic acetylcholine receptors composed of α9 α10 subunits. The subunit necessary for mediating effects on as genetic deletion results functional de-efferentation cochlea. Cholinergic modulation spontaneous cochlear activity before hearing onset important maturation central auditory...
Information processing in the brain requires reliable synaptic transmission. High reliability at specialized auditory nerve synapses cochlear nucleus results from many release sites (N), high probability of neurotransmitter (Pr), and large quantal size (Q). However, Pr also causes to depress strongly when activated normal rates for a prolonged period, which reduces fidelity. We studied how are influenced by activity exposing mice constant, nondamaging noise found that changed facilitating,...
Non‐technical summary Localization of sound sources in the azimuth, which makes use interaural differences timing and/or intensity acoustic signals, is vital importance for most mammals. Using small time arrival at two ears requires that propagation electric pulses auditory system be temporally precise. In this study, we found elimination GluA4, a protein particularly abundant cells, significantly impairs their ability to faithfully transmit leading profound deficits responses stimuli mice....
Spherical and globular bushy cells of the AVCN receive huge auditory nerve endings specialized for high fidelity neural transmission in response to acoustic events. Recent studies mice other rodent species suggest that distinction between cell subtypes is not always straightforward. We conducted a systematic investigation mouse along rostral-caudal axis an effort understand morphological variation gives rise reported properties mice. combined quantitative light electron microscopy...
ABSTRACT Periodic spontaneous activity is a key feature of developing sensory systems, essential for the formation and refinement neural circuits. Before onset hearing in altricial mammals, cochlear inner hair cells exhibit electrical that activates primary afferents to propagate into central nervous system. This activity, modulated by medial olivocochlear efferent feedback via α9α10 nicotinic cholinergic receptors present cells, crucial auditory system maturation. In this study, we examined...
Alzheimer's disease (AD) is a form of dementia in which memory and cognitive decline thought to arise from underlying neurodegeneration. These impairments, however, are transient when they first appear can fluctuate across progression. Here, we investigate the neural mechanisms fluctuations performance amnestic mice. We trained APP/PS1+ mice on an auditory go/no-go task that dissociated learning contingencies (knowledge) its more variable expression under reinforcement (performance)....
Hair cells of the cochlea are mechanosensors for perception sound. Mutations in LRTOMT gene, which encodes a protein with homology to catecholamine methyltransferase COMT that is linked schizophrenia, cause deafness. Here, we show Tomt/Comt2, murine ortholog LRTOMT, has an unexpected function regulation mechanotransduction by hair cells. The role mTOMT independent and mCOMT cannot substitute function. Instead, binds putative components channel essential transport some these into mechanically...
Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration deafening strengthens TC primary visual cortex (V1) mice. Here, we demonstrate restores NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) onto principal neurons V1 layer 4 (L4), which accompanied by an increase NMDAR function. In contrast, did not recover depression (LTD) at synapses. Potentiation absent...