A5023724699- Renal Transplantation Outcomes and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Cannabis and Cannabinoid Research
- Pharmacological Effects and Toxicity Studies
- Helminth infection and control
- Neurological Complications and Syndromes
- Intestinal and Peritoneal Adhesions
- Sulfur-Based Synthesis Techniques
- Hernia repair and management
- Tryptophan and brain disorders
- Parasite Biology and Host Interactions
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Gastrointestinal disorders and treatments
- Parasites and Host Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Cholinesterase and Neurodegenerative Diseases
- Dye analysis and toxicity
- Parasitic Diseases Research and Treatment
Zoetis (United States)
2021-2025
University of Toledo
2016-2024
Epsom Hospital
1968
Cannabis sativa , or marijuana, a popular recreational drug, alters sensory perception and exerts range of potential medicinal benefits. The present study demonstrates that the endogenous cannabinoid receptor agonists 2-arachidonoylglycerol (2-AG) anandamide (AEA) activate canonical in Caenorhabditis elegans also modulate monoaminergic signaling at multiple levels. 2-AG AEA inhibit nociception feeding through pathway requiring cannabinoid-like NPR-19. NPR-19 directly cannabinoid-dependent...
The ability to detect noxious stimuli, process the nociceptive signal, and elicit an appropriate behavioral response is essential for survival. In Caenorhabditis elegans, opioid receptor agonists, such as morphine, mimic serotonin, suppress overall withdrawal from stimuli through a pathway requiring opioid-like receptor, NPR-17. This serotonin- or morphine-dependent modulation can be rescued in npr-17-null animals by expression of npr-17 human κ two ASI sensory neurons, with signaling...
Monoamines and neuropeptides often modulate the same behavior, but monoaminergic-peptidergic crosstalk remains poorly understood. In Caenorhabditis elegans, adrenergic-like ligands, tyramine (TA) octopamine (OA) require distinct subsets of in two ASI sensory neurons to inhibit nociception. TA selectively increases release encoded by nlp-14 or nlp-18 from either synaptic/perisynaptic regions axons soma, respectively, OA nlp-9 asymmetrically, only region right axon. The predicted amino acid...
The canine heartworm, Dirofilaria immitis, is among the most important parasites of dogs in United States and worldwide, may cause severe potentially fatal disease. Current diagnostic recommendations rely on serological detection an adult female antigen, visualization microfilariae blood. Therefore, a reliable diagnosis can be only performed approximately six months post-infection. There growing need to characterize novel markers that are capable detecting early stages heartworm infection,...
BACKGROUND Small bowel obstructions (SBO) are common and can be caused by various pathologies including intra-abdominal adhesions hernias. Less frequently, these malignancy. The following article will review the etiology treatment of SBOs, discuss complications hernia repair with mesh, examine if there is an association between mesh cancer. CASE REPORT We present case a man who was over 89 years old presented SBO that failed non-operative management. He previously had bilateral inguinal...