A5004978107- Amyotrophic Lateral Sclerosis Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurogenetic and Muscular Disorders Research
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Breastfeeding Practices and Influences
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Circadian rhythm and melatonin
- Pituitary Gland Disorders and Treatments
- Photoreceptor and optogenetics research
- Phagocytosis and Immune Regulation
- Neurotransmitter Receptor Influence on Behavior
- Pain Management and Placebo Effect
- Neonatal Respiratory Health Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Milk Quality and Mastitis in Dairy Cows
- Pasture and Agricultural Systems
Mayo Clinic in Florida
2020-2024
WinnMed
2020-2024
Mayo Clinic
2024
Jacksonville College
2020-2024
Jacksonville University
2022
Centro Universitário da Fundação de Ensino Octávio Bastos
2005-2014
Universidade de São Paulo
2007
Abstract A repeat expansion in the C9orf72 (C9) gene is most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate single nucleus transcriptomics (snRNA-seq) epigenomics (snATAC-seq) postmortem motor frontal cortices from C9-ALS, C9-FTD, control donors. C9-ALS donors present pervasive alterations expression with concordant changes chromatin accessibility histone modifications. The greatest occur upper deep layer excitatory neurons,...
Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate tangle distribution and are relevant for understanding glial activation considerations therapeutic advancement.
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two devastating fatal neurodegenerative conditions. While distinct, they share many clinical, genetic, pathological characteristics 1 , both show selective vulnerability of layer 5b extratelencephalic-projecting cortical populations, including Betz cells in ALS 2,3 von Economo neurons (VENs) FTLD 4,5 . Here, we report the first high resolution single-cell atlas human primary motor cortex (MCX) its...
To analyze opioid intake interference with psychological, well-being, and functional outcomes medication tapering in patients fibromyalgia admitted to the Mayo Clinic Pain Rehabilitation Program (MCPRP) Florida.
É comum o clínico veterinário submeter animais à quimioterapia para controle de neoplasias e observar depressão medular, com presença anemia, leucopenia trombocitopenia como efeitos colaterais. Nesses casos, podem-se adotar duas condutas: supressão da e/ou utilização estimulantes medula óssea. Dentre os medicamentos mais utilizados, podemos citar decanoato nandrolona (Deca-durabolin®), cuja eficácia domésticos é pouco estudada, poucos relatos na literatura nacional internacional. Este...
The aim of this study was to investigate the possible effects reproductive experience on dopaminergic profile in three different brain tissues, hypothalamus, striatum and cortex rats 7th-8th day pregnancy during light-dark shift (between 1700-1900h). Results showed that dopamine levels increased DOPAC/DA decreased as a function parity. In cortex, no differences were observed. striata, haloperidol-induced HVA HVA/DA increases less intense experienced animals. These findings suggested produced...
Abstract Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are strongly influenced by inherited genetic variation, but environmental epigenetic factors also play key roles in the course of these diseases. A hexanucleotide repeat expansion C9orf72 (C9) gene is most common cause ALS FTD. To determine cellular alterations associated with C9 expansion, we performed single nucleus transcriptomics (snRNA-seq) epigenomics (snATAC-seq)...
Foi investigada a possível relação entre as concentrações de ocitocina no líquido céfalo-raquidiano e soro em diferentes formas ordenha ovinos. Foram utilizadas dez ovelhas multíparas divididas quatro grupos acordo com o estímulo para ejeção do leite: exclusivamente mecânica (EM), mista mamada os carneiros separados das mães durante noite reunidos elas pela manhã amamentação (MMS); manual apenas natural (ES). coletadas amostras fluido cerebroespinhal sangue simultaneamente ordenhas. A média,...
Foi investigada a possível relação entre as concentrações de ocitocina no líquido céfalo-raquidiano e soro em diferentes formas ordenha ovinos. Foram utilizadas dez ovelhas multíparas divididas quatro grupos acordo com o estímulo para ejeção do leite: exclusivamente mecânica (EM), mista mamada os carneiros separados das mães durante noite reunidos elas pela manhã amamentação (MMS); manual apenas natural (ES). coletadas amostras fluido cerebroespinhal sangue simultaneamente ordenhas. A média,...
Background: Selective corticolimbic vulnerability to tau pathology in Alzheimer’s disease (AD) underlies clinicopathologic heterogeneity. We aimed re-express the AD subtype algorithm as a index (CLix) quantitatively examine heterogeneity and deeply phenotype patterns of glial activation neuropathologically diagnosed AD.Methods: CLix was developed (n=1361) collapse spatial distribution thioflavin-S tangle counts assign continuum: relative hippocampal sparing with cortical predominance (<10),...
A prolactina (PRL) tem efeito modulatório sobre a atividade neuronal no sistema nervoso central, fato este relevante do ponto de vista fisiológico e comportamental. Os efeitos estimulatórios inibitórios da PRL exógena estão fortemente relacionados com dose o tempo tratamento. injeção diretamente central pode levar modulação dopaminérgica tanto aguda como prolongadamente, já foi observado anteriormente em ratos. Por outro lado, esse neurotransmissão também ser modificado por uma experiência...