A5039973759- Renal cell carcinoma treatment
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Renal and related cancers
- Lysosomal Storage Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Bladder and Urothelial Cancer Treatments
- Chronic Kidney Disease and Diabetes
- HIV Research and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple and Secondary Primary Cancers
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Systemic Sclerosis and Related Diseases
- Biomedical Research and Pathophysiology
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Renal Transplantation Outcomes and Treatments
- HIV-related health complications and treatments
- Systemic Lupus Erythematosus Research
- IL-33, ST2, and ILC Pathways
- Renal and Vascular Pathologies
- Eosinophilic Disorders and Syndromes
Haukeland University Hospital
2013-2024
University of Bergen
2012-2023
Makerere University
2010
UiT The Arctic University of Norway
1985-1992
Sjællands Universitetshospital, Nykøbing F.
1992
Centre for Arctic Gas Hydrate, Environment and Climate
1992
University Hospital of North Norway
1982-1991
St Bartholomew's Hospital
1987
Summary Background and objectives Skepticism about performing renal biopsies is often because of uncertainty regarding risk complications. The aim this study was to evaluate safety relevant complications in pediatric adult patients a large national registry study. Design, setting, participants, & measurements Kidney reported the Norwegian Biopsy Registry from 1988 2010 were included. Risk factors for major (blood transfusion and/or surgical or catheter intervention) analyzed using...
The effect of early-onset enzyme replacement therapy on renal morphologic features in Fabry disease is largely unknown. Here, we evaluated the 5 years treatment with agalsidase alfa or beta 12 consecutive patients age 7–33 (median age, 16.5 years). We performed biopsies at baseline and after therapy; 7 had additional 1 3 years. After a median 65 months, biopsy findings from all showed total clearance glomerular endothelial mesangial cell inclusions, 2 complete inclusions epithelial cells...
OBJECTIVE--To examine the association between dyspeptic symptoms and endoscopic histological diagnoses. DESIGN--Cross sectional study of people with dyspepsia controls matched for age sex identified by questionnaire survey all inhabitants aged 20 to 69. Endoscopy examination was performed examiner blind whether or not patient had dyspepsia. SETTING--Population based in Sørreisa, Norway. SUBJECTS--All without were offered endoscopy. A total 309 310 underwent endoscopy, giving 273 pairs. MAIN...
Background. In Fabry nephropathy, alpha-galactosidase deficiency leads to accumulation of glycosphingolipids in all kidney cell types, proteinuria and progressive loss function.
The aim of this study was to evaluate the clinical course patients with Wegener's granulomatosis and renal involvement, special reference relapse rate, patient survival morbidity from serious infections.A retrospective analysis carried out 108 presenting active disease in eight hospitals Norway between 1988 1998. Multivariate used investigate whether selected variables predicted relapse, infections.Median follow-up 41.5 months. Twenty-two (20.4%) were admitted a need for dialysis. Complete...
To determine the association between infection with Helicobacter pylori and dyspepsia.Cross sectional study of dyspeptic subjects age sex matched controls identified by a questionnaire survey all inhabitants aged 20-69. (Endoscopy, histological examination, microbiological examinations biopsies from gastric mucosa were performed blind.)Population based in Sørreisa, Norway.All 782 (excluding those previous history peptic ulcer, gall stones or kidney stones, coronary heart disease) offered an...
A kidney biopsy is preferred for the diagnosis of ANCA-associated vasculitis with renal involvement. The aim our study was to evaluate prognostic value a histopathologic classification scheme recently proposed by an international consortium pathologists in large Norwegian cohort.Patients diagnosed GN were included from Kidney Biopsy Registry 1991-2012. Renal morphology classified as focal, mixed, crescentic, or sclerotic. Study end point ESRD. Patients followed 2012.Two hundred fifty...
Background. The main purpose of this study was to examine histopathological changes seen in renal biopsies from patients with Wegener's granulomatosis (WG) varying degrees involvement and possible correlations between the morphological variables severity disease.
Strong associations of adverse perinatal outcomes have been identified with later cardiovascular disease in the mother. Few studies addressed kidney disease. This study investigated whether are associated clinical as diagnosed by biopsy. The Medical Birth Registry Norway contains data on all childbirths since 1967. Norwegian Kidney Biopsy biopsies 1988. All women a first singleton delivery from 1967 to 1998 were included. Pregnancy-related predictors biopsy analyzed Cox regression analyses....
High-affinity [3H]folate binding in solubilized human choroid plexus homogenate displayed characteristics, e.g. apparent positive co-operativity, which are typical of specific folate binding. The highest folate-binding activity per g protein was associated with the 27000 membrane pellet where membrane-marker enzyme gamma-glutamyltransferase had its main localization. Ultrogel AcA 44 chromatography revealed two major proteins (molecular masses greater than 110 kDa and approx. 100 kDa) one...
The Oxford classification/MEST score is an established histopathologic scoring system for patients with IgA nephropathy (IgAN). objective of this study was to derive a prognostic model IgAN based on the MEST and features.A total 306 biopsy-proven primary were included. Histopathologic samples retrieved from Norwegian Kidney Biopsy Registry reclassified according classification. endpoint end-stage renal disease (ESRD). Patients subclassified into three risk models histologic features (Model...
Multiple sensitivity to metals is often seen in humans. This may be due cross-reactivity or multiple sensitization. The pattern of some metal compounds was studied, using the guinea pig maximization test method. Animals were induced with K2Cr2O7 and CoCl2, respectively, then challenged K2Cr2O7, NiSO4, PdCl2 RhCl3. No simultaneous reactivity recorded. supports view that patients nickel-cobalt chromate-cobalt exposure sensitization, not cross-reactivity. purity analysed.
Background. A recent study has shown that preeclampsia is an important risk marker for end-stage renal disease (ESRD), but the underlying mechanisms are unclear. The present investigated whether previous was associated with progression of established kidney disease. Material andmethods. Data from Norwegian Kidney Biopsy Registry and Medical Birth Norway were linked. We included women who, after their last pregnancy, had a representative biopsy in 1988–2005. Women followed up development ESRD...
Abstract Purpose An improved understanding of RCC immunology should shed further light on tumor biology. Our objective was to study what extent serum levels the IL-6 family cytokines at diagnosis were relevant survival. Methods A total 118 consecutively patients with RCC, in which surgically removed Haukeland University Hospital during period from 2007 2010, included. The followed-up for 10 years. morning before surgery blood sampled and frozen, IL-6, IL-27, IL-31, OSM, CNTF, IL-6Rα gp130...
Lesions of the gastrointestinal tract with massive tissue eosinophilia may present a difficult diagnostic problem. In series 250 lymphomas drawn from files St Bartholomew's and Mark's Hospitals there were 28 cases lymphoma distinctive histological features, characterized by eosinophilia. Two these tumours in stomach 26 small intestine. Eight latter associated coeliac disease. On low power examination zoning phenomenon was regularly seen fissuring ulceration, perforation fistula formation,...
We evaluated possible associations among thrombospondin-1, p53 expression, microvessel density, cell proliferation index, nuclear grade, tumor stage and continuously coded size in clear renal carcinoma. The value of thrombospondin-1 as a prognostic marker carcinoma was examined.A total 172 consecutive patients with treated radical nephrectomy were initially enrolled the study. However, due to technical problems lack material 12 cases excluded from analysis. A 68 (43%) died 46 (29%) other...
This study aimed to assess the impact of preoperative body mass index (BMI) on postoperative complications, cancer-specific survival (CSS) and overall (OS) in patients operated for renal cell carcinoma (RCC).The included 397 with BMI values, who underwent surgery RCC between 1 January 1997 31 December 2010. Obese (BMI > 30 kg/m(2)) were compared non-obese < regard CSS OS. A Cox proportional hazard model was used multivariate analyses. The mean age 62.1 years. There 259 males (65%) 325 (82%)...
Human papillomavirus (HPV) infection is a risk factor for the development of penile squamous cell carcinoma (PSCC). It remains inconclusive whether HPV-related PSCC has different prognosis from non-HPV-related PSCC.