Osteocalcin, a marker of bone formation, is also known as regulator glucose and fat mass. The purpose this study was to determine the association between obesity, metabolic risks serum osteocalcin in postmenopausal women.We selected 214 women determined osteocalcin, fasting plasma (FPG), insulin, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment insulin resistance (HOMA-IR), lipid profile, anthropometric values (body mass index [BMI], waist-to-hip ratio [WHR], body...

Müllerian inhibiting substance (MIS) is produced in Sertoli cells of fetal testis and causes regression müllerian ducts male embryos. MIS also can induce the cell cycle arrest apoptosis duct-derived tumors vivo vitro.Our objective was to investigate expression type II receptor (MISR II) whether inhibit proliferation primary cultures endometrial stromal (ESC) endometriosis.In vitro experiments were performed university research laboratory.Tissue samples from 12 patients who had undergone...

Objectives:The aim of this study was to determine the relationship ovarian volume (OV) age, height, and weight in Korean young women with polycystic ovary syndrome (PCOS) undergoing ultrasonography (US) investigate between follicle count on US serum hormone levels including anti-Müllerian (AMH) gonadotropin.Methods: A total 272 nulliparous aged 15 39 years who were newly diagnosed PCOS at a university hospital included study.Evaluation ovaries measurement OVs all cases randomly performed by...

<b><i>Background/Aims:</i></b> The purpose of this study was to identify predictive markers for tubo-ovarian abscess (TOA) through a comparison clinical and laboratory data in patients diagnosed with pelvic inflammatory disease (PID). <b><i>Methods:</i></b> We reviewed the medical charts 499 females who were admitted hospital clinical, surgical, imaging-based diagnoses PID between 2001 2011. divided into following two groups: (1) TOA (2)...

Background: Uterine artery embolization (UAE) is one of the minimally-invasive alternatives to hysterectomy for treatment uterine leiomyomas. There are various factors affecting outcomes UAE, but these have only been sporadically studied. Study Objective: To identify associated with efficacy UAE leiomyoma, and develop a model prediction response leiomyomas UAE. design: A retrospective cohort study (Canadian Task Force Classification II-2) Patients: One hundred ninety-eight patients...

Müllerian inhibiting substance (MIS), also known as anti-Müllerian hormone (AMH), is a member of the transforming growth factor-β (TGF-β) superfamily that plays an important role in mesenchymal-epithelial interaction, cell and proliferation, extracellular matrix production tissue remodeling. Previously, we demonstrated MIS suppressed ovarian cancer suggested large-scale genetic elements could be responsible for anti-neoplastic effects on cells. In this study, expression type II receptor...

Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) has been suggested as a biotherapeutic agent in gynecological cancers that highly express the MIS/AMH type II receptors (MISRII/AMHRII) but anticancer mechanisms by which acts are not fully understood. Our experiments show inhibits ovarian cancer deregulating Wnt signal pathway via β-catenin interacting protein (ICAT). inhibition of ICAT small interfering RNAs (siRNA) decreased driven cell viability measured...

Müllerian-inhibiting substance/anti-Müllerian hormone (MIS/AMH) is produced in the ovarian granulosa cells, and it believed to inhibit folliculogenesis steroidogenesis women of reproductive age.To investigate expression MIS/AMH type II receptor (MISRII/AMHRII) that binds ovaries reproductive-age women; identify exact targets MIS/AMH.Laboratory study using human tissue.University hospital.Tissue samples from 25 patients who had undergone surgery.The segregation theca cells by laser...

Müllerian inhibiting substance (MIS) has been shown to inhibit growth of a number tumors in vitro and/or vivo, but the downstream pathways which it regulates are not fully understood. In present study we show that MIS type II receptor was highly expressed AN3CA cells, cell line derived from human endometrial cancer MIS-treatment caused reduction viability, and induced cellular apoptosis genes involved cycle arrest. To understand genome-wide effects on gene regulation, performed serial...

Objectives: Metabolic syndrome components, insulin resistance and central obesity cause type 2 diabetes hypertension. This will increase the risk of cardiovascular disease. Women after menopause are at increased metabolic syndrome. Several researchers studied that in menopause, mortality. We impact on mortality postmenopausal women with Republic Korea. Methods: Twenty four thousand nine hundred forty aged 40 years or older were enrolled health promotion centers national university hospital...

The purpose of this study was to investigate the large-scale characteristic molecular signature Müllerian inhibiting substance (MIS) in human ovarian cancer cells through expression genomics. To understand comprehensive mechanisms by which MIS inhibits cell growth, we identified changes elicited line OVCAR-8, using DNA microarray analysis. Combined serial gene analysis from 0 96 h after treatment OVCAR-8 resulted 759 genes showed at least a 2-fold change overexpression or underexpression...

Abstract Although endometriosis is a common disease in women of reproductive age, rectal rare and lymph node involvement by considered uncommon. We report 37‐year‐old woman who had irregular lower abdominal pain changes bowel habits. She was operated on with suspected cancer, but the histological diagnosis involvement. In suffer from digestive complaints, should be differential diagnosis. Rectal has ability to invade adjacent tissue as true malignant tumors. Therefore, endometriosis.

We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate possibility using MIS/anti-Müllerian (AMH) as a biological regulator or therapeutic agent patients with leiomyoma adenomyosis.We studied normal myometrium, leiomyoma, endometrial tissue, from 57 who underwent hysterectomy for (22 cases) (28 myomectomy (7 cases). Immunohistochemical staining was used confirm MIS/AMHRII protein...

Objectives: Submucosal leiomyoma commonly causes abnormal uterine bleeding, menstrual abnormalities, and infertility, is usually treated by hysteroscopy. However, not all submucosal leiomyomas can be hysteroscopy; patients with high-scoring must undergo transabdominal myomectomy to preserve the uterus. This article reports experience a group of who underwent transvaginal radiofrequency (RF) thermal ablation grades, emphasis on safety efficacy this procedure. Study design: was prospective...

Research Question: To evaluate the effect of mistletoe on cell viability patients with endometriosis, expression levels vascular endothelial growth factor (VEGF) were measured, and change in level VEGF following treatment was recorded.Design: Forty reproductive-aged women endometriosis (stage I/II [group 1, n=20], stage III/IV 2, n=20]) prospectively enrolled.Twenty who underwent gynaecologic operations for benign conditions selected as control group.Both eutopic ectopic endometrial tissues...