A5100435383- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Mercury impact and mitigation studies
- Diabetes and associated disorders
- Heavy Metal Exposure and Toxicity
- Diabetes Management and Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Medical Research and Treatments
- Trace Elements in Health
- Educational Reforms and Innovations
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Breast Cancer Treatment Studies
- Atmospheric chemistry and aerosols
- Air Quality Monitoring and Forecasting
- Effects and risks of endocrine disrupting chemicals
- Indoor Air Quality and Microbial Exposure
- Water Treatment and Disinfection
- Complex Network Analysis Techniques
- Mesenchymal stem cell research
- Environmental Toxicology and Ecotoxicology
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Medicinal Plants
- Stochastic processes and statistical mechanics
- Estrogen and related hormone effects
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2016-2025
Nanjing University
2024-2025
Shaanxi University of Chinese Medicine
2024
Guizhou Center for Disease Control and Prevention
2024
Tongji University
2011-2023
Nankai University
2023
Sichuan University
2023
Shanghai Jiao Tong University
2023
South China Normal University
2023
Mercury (Hg) contamination poses a persistent threat to the remote Arctic ecosystem, yet mechanisms driving pronounced summer rebound of atmospheric gaseous elemental Hg (Hg0) and its subsequent fate remain unclear due limitations in large-scale seasonal studies. Here, we use an integrated atmosphere–land–sea-ice–ocean model simulate cycling comprehensively. Our results indicate that oceanic evasion is dominant source (~80%) Hg0 rebound, particularly driven by seawater release facilitated...
Abstract Objective Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most common emergencies (HEs) associated with diabetes mellitus. Individuals HEs can present combined features of DKA HHS. The objective this study is to assess clinical characteristics, therapeutic outcomes, predisposing factors type 2 diabetic patients isolated or in China. Methods We performed a retrospective analysis 158 (T2DM), complicated DKA, HHS, HHS (DKA-HHS) Shanghai Tongji...
A retrospective study of autopsy cases was conducted at the Department Forensic Medicine, Tongji Medical College (DFM-TMC), in Hubei, China to describe characteristics poisoning deaths from 1999 2008. total 212 were investigated by DFM-TMC during 10-year period. The ranged 17 27 Of cases, 82 (38.7%) pesticides, 36 (17.0%) carbon monoxide, 34 (16.0%) drugs, 22 (10.4%) alcohol, (8.0%) other chemicals, 15 (7.1%) poisonous plants and animals, six (2.8%) heavy metals. pesticide deaths, 43 (52.4%)...
Air conditioning is a crucial participant in indoor air circulation and harmful microorganism transmission. To elucidate microbial contamination systems, bacteria, fungi, pollens residential (AC) filters Shanghai were revealed. The concentrations of fungal ITS (1,972,037 ± 5,025,505 copies/cm2) most filter samples considerably higher than the 16S rRNA gene (21,587 21,461 copies/cm2). multitudinous bacteria determined richness, whereas trend was not line with owing to Aspergillus flourishing,...
Evidence on how beverage consumption modifies associations between air pollution (AP) exposure with the type 2 diabetes (T2D) risk remains scarce, which we aimed to investigate in this study. A total of 77,278 adults from UK Biobank cohort were enrolled. Annual average concentrations fine particulate matter (PM2.5 and PM10) nitrogen oxides (NO2 NOX) estimated represent long-term AP using land use regression model. The beverages (alcoholic beverages, juice, sugar-sweetened [SSB], coffee, tea)...
Lead (Pb) is a widespread neurotoxic pollutant. Pb exposure associated with mood disorders, no well-established neural mechanisms elucidated. In the present study, we aimed to investigate whether excitatory neurons in dentate gyrus subregion of ventral hippocampus (vDG) played key role Pb-induced anxiety and depression-like behaviors. C57BL/6 mice were exposed 100 ppm starting on day 1 pregnancy until experiments performed using offspring. Behavioral studies suggested that chronic triggered...
8600 Background: Despite the significant improvement in progression-free survival (PFS) for non-small cell lung cancer (NSCLC) patients with EGFR mutations, attributed to advent of third-generation tyrosine kinase inhibitors (TKIs), inevitable development acquired resistance continues pose a critical challenge that severely affects long-term efficacy these treatments. This study aims evaluate and safety anlotinib combination EGFR-TKIs advanced NSCLC experiencing gradual or oligo progression...
Introduced in the early 1980s, synthetic pyrethroids (SPs) are widely used controlling a multitude of agricultural and domestic insect species, but they highly toxic to fish aquatic invertebrates. To date, however, studies have not adequately associated enantioselectivity biological behavior with toxicity, especially regarding uptake chronic toxicity. This study aimed elucidate relationship between enantioselective toxicity accumulation cis-bifenthrin (cis-BF) Daphnia magna by 14C-labeled...
The mechanisms of Bisphenol A (BPA) induced learning and memory impairment have still not been fully elucidated. MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules involved in the process toxicant-induced neurotoxicity. To investigate role miRNAs BPA-induced impairment, we analyzed impacts BPA on miRNA expression profile by high-throughput sequencing mice hippocampus. Results showed that treated with displayed impairments spatial changes Seventeen were significantly...
Secondhand smoke (SHS) is a major risk factor for poor health outcomes among women in China, where proportionately few smoke. This especially the case as it pertains to women's reproductive health, specifically migrant who are exposed SHS more than population at large. There several factors which may increase of exposure. paper aims investigate prevalence and associated exposure internal Chinese age. The data used were derived from 2014 Labor Dynamic Survey, national representative panel...
To elucidate the mechanism of how liver participates in PM2.5-caused insulin resistance. A novel Wistar rat model was developed this study by instilling a suspension lyophilized PM2.5 sample (2.5 mg/kg, 5 or 10 mg/kg) collected from atmosphere. Systemic resistance indicators, including serum fasting blood glucose (FBG), (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and hemoglobin A1 (HbA1), were upregulated instillation. The area under curve (AUCglu) calculated...
<i>Background:</i> Multidrug resistance (MDR) presents a serious problem in cancer chemotherapy. Our previous studies have shown that the MDR of K562/DOX cells could be reversed by guggulsterone through inhibiting function and expression P-glycoprotein. The purpose this study was to investigate reversal effect on drug-resistant MCF-7 parental cells. <i>Methods:</i> MTT cytotoxicity assays, flow cytometry, Western blot analysis were performed antiproliferative effects...
The aim of the present study was to examine association between plasma heavy metals and metabolome in patients with breast cancer (BC), development. Nuclear magnetic resonance used determine metabolites involved an inductively coupled mass spectrometry system quantify samples. It indicated that cadmium significantly higher BC compared control population (~15‑fold increase). Chromium, arsenic lead were also elevated by ~3.24, 2.14 1.52 fold, respectively. A number small molecules, including...
Glutaric aciduria type II (GA II) is an autosomal recessive disorder affecting fatty acid and amino metabolism. The late-onset form of GA almost exclusively associated with mutations in the electron transfer flavoprotein dehydrogenase (ETFDH) gene. Till now, clinical features vary widely pose a great challenge for diagnosis. aim current study to characterize phenotypes genetic basis GAII patient. In this study, we described biochemical manifestations 23-year-old female Chinese patient II,...
Background and Objectives: Studies that investigate the links between particulate matter ≤2. 5 μm (PM2.5) hypertension among elderly population, especially those including aged over 80 years, are limited. Therefore, we aimed to examine association PM2.5 exposure risk of incidence Chinese elderly. Methods: This prospective cohort study used 2008, 2011, 2014, 2018 wave data from a public database, Longitudinal Healthy Longevity Survey, national survey investigating health 65 years in China. We...
Frequent M. aeruginosa outbreaks pose a major risk to public health and have detrimental effect on aquatic ecosystems. Researchers are looking into ways stop control blooms, problem that affects both the environment human significantly. It is important develop proper monitoring methods identify blooms. However, existing techniques some drawbacks limit field’s applicability. Therefore, we must improve current for effectively controlling Mitigation strategies should be customized particular...
Abstract. The air–sea exchange of elemental mercury (Hg0) plays an important role in the global Hg cycle. Existing models for Hg0 have not considered impact sea surfactants and wave breaking on velocity, leading to insufficient constraints flux Hg0. In this study, we improved model three-dimensional ocean transport MITgcm (MIT General Circulation Model) by incorporating wave-breaking processes through parameterization, utilizing total organic carbon concentration significant height data....