A5042058888- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Malaria Research and Control
Instituto de Saúde
2024
Universidade Federal do Triângulo Mineiro
2014
Background. During dengue virus (DV) infection, monocytes produce tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) which might be critical to immunopathogenesis. Since intensity of DV replication may determine clinical outcomes, it is important know the effects viral nonstructural protein 1 (NS1) on innate immune parameters infected patients. The present study investigates relationships between serum levels response (TLR4 expression TNF-α/NO production) patients presenting different...
Background: The intensity of dengue virus (DV) replication and circulating non-structural protein 1 (NS1) levels may promote changes in the human immune response favor severe forms infection. We investigated correlations between NS1 with CXCL-8, CXCL-10, IFN-γ, IL-12p40 serum levels, IFN-γ receptor α chain (CD119) expression, CXCL10 production by peripheral blood mononuclear cells (PBMCs) stimulated recombinant DV-infected patients different clinical forms. Methods: Dengue NS1, were measured...