A5048597321- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- NF-κB Signaling Pathways
- Nicotinic Acetylcholine Receptors Study
- Laser Applications in Dentistry and Medicine
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- GABA and Rice Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Neurogenetic and Muscular Disorders Research
- Medicinal Plants and Neuroprotection
- Synthesis of Tetrazole Derivatives
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Plant Micronutrient Interactions and Effects
- Gut microbiota and health
Fenerbahçe University
2024
Istanbul Arel University
2022
Atlas Üniversitesi
2022
Istanbul Medipol University
2019-2020
Istanbul Aydın University
2020
Istanbul University
2019
: The role of the gut microbiome in development and progression many diseases has received increased attention recent years. Boron, a trace mineral found dietary sources, attracted interest due to its unique electron depletion coordination characteristics chemistry, as well potential modulating microbiota. This study investigates effects inorganic boron derivatives on microbiota mice.
Abstract Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3‐triazine, 1,3,5‐triazine ( s ‐triazine) and 1,2,4‐triazine. All of these skeletons were investigated. Among them, 5,6‐diaryltriazines previously tested on MCF7 other tumor cell lines. In this study, we have synthesized characterized 9 novel 5,6‐diaryl‐1,2,4‐triazine derivatives 4a‐i ) using 1 HNMR, 13 CNMR, HRMS spectra. Contributing the previous...
Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms diverse metabolic functions, including nitrogen fixation microorganisms, cell wall stability plants, bone carbohydrate metabolism animals. The number of studies about the effect boron biological model systems very limited; so far, there has been no study on correlation between amyloid-beta toxicity. Here, we investigated possible effects 2...
Aim: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons.Als2 one of the genes that cause ALS, and its mutations leads to loss function in alsin protein.The interaction between alsin, UXT protein has been documented vitro.UXT cofactor NF-κB pathway.Our aim investigate potential effect silencing Als2 on activity pathway primary neurons.Method: Neurons were demonstrated immunocytochemically via reaction with anti-ChAT anti-βIII tubulin antibodies spinal...
Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but diversity of experimental strategies and analyses non-standardised therapeutic trials are challenging. In this respect, there no cases successful clinical application such candidate molecules when it comes to human patients.After 24 hours culturing, three different minocycline (Sigma-Aldrich, M9511, Germany) concentrations (1 μM, 10 μM 100 μM) were added primary cortical...
Objective: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting spinal and cortical motor neurons.Motor neuron degeneration leads to progressive muscular atrophy.Als2 (alsin) one of the causative genes ALS UXT gene an interacting partner Als2.Since known cofactor in NF-κB enhancesome, we aimed here compare effects Als2 silencing on activity by using N2a C2C12 cell lines.Methods: Mouse neuroblastoma cells (N2a) myoblast lines (C2C12) were used.Als2 was silenced RNAi...
Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to disintegration of synaptic connection neurotrophic factors could not be transported retrogradely towards cell body deprivation trophic lead degeneration death injured neuron. Rifampicin an antibiotic exhibiting several neuroprotective functions various neurodegenerative conditions. Here we aim investigate acute effect rifampicin primary cortical neuron culture...