A5024307786- Coronary Interventions and Diagnostics
- Immune Cell Function and Interaction
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Crystallization and Solubility Studies
- Palliative Care and End-of-Life Issues
- Neuropeptides and Animal Physiology
- X-ray Diffraction in Crystallography
- Cardiac Valve Diseases and Treatments
- Smart Materials for Construction
- Structural Health Monitoring Techniques
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Dialysis and Renal Disease Management
- Receptor Mechanisms and Signaling
- Luminescence Properties of Advanced Materials
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Concrete Corrosion and Durability
- Dermatology and Skin Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
Osaka University
2013-2025
St. Marianna University School of Medicine
2022-2025
Fukuoka Dental College
2024-2025
Tohoku University
2022-2025
Konan Kosei Hospital
2020-2024
RIKEN Center for Integrative Medical Sciences
2018-2024
Jikei University School of Medicine
2024
University of California, San Francisco
2020-2024
Mizuho (Japan)
2021-2024
Sapporo Toho Hospital
2021-2024
A specific and sensitive radioimmunoassay for adrenomedullin has been developed. Half-maximal inhibition of binding radioiodinated was observed at 4 fmol/tube. The recognized the entire molecule little crossreactivity with fragment peptides. Adrenomedullin-like immunoreactivity found to circulate in human plasma considerable concentration (3.3 +/- 0.39 fmol/ml). eluted almost same position as synthetic on gel-filtration chromatography reverse-phase high-performance liquid chromatography,...
Since recent publications suggested that the survival of cancer cells depends on MTH1 to avoid incorporation oxidized nucleotides into cellular DNA, has attracted attention as a potential therapeutic target. In this study, we identified new purine-based inhibitors by chemical array screening. However, although in study targeted MTH1, they exhibited only weak cytotoxicity against compared recently reported first-in-class inhibitors. We performed proteomic profiling investigate modes action...
We measured plasma concentrations of adrenomedullin (AM), a novel bioactive peptide with potent vasodilator activity, in 21 patients chronic congestive heart failure due to various diseases and compared them levels age- sex-matched healthy subjects examine the pathophysiological role AM failure. In addition, relationship between other hormones known control cardiovascular system was examined these patients. The level significantly (P < 0.01) higher than that (mean +/- SEM, 2.94 0.15 fmol/mL;...
Background. Research suggests that desired family involvement (FI) in medical decision making may depend on cultural values. Unfortunately, the field lacks cross-cultural studies test this assumption. As a result, providers be guided by incomplete information or biases rather than patient preferences. Methods. Researchers developed 6 culturally relevant disease scenarios varying from low to high seriousness. Quota samples of approximately 290 middle-aged urban residents Australia, China,...
Oil-rich algae have promising potential for a next-generation biofuel feedstock. Pseudochoricystis ellipsoidea MBIC 11204, novel unicellular green algal strain, accumulates large amount of oil (lipids) in nitrogen-deficient (-N) conditions. Although the bodies are easily visualized by lipophilic staining cells, little is known about how metabolically synthesized. Clarifying metabolic profiles -N conditions important to understand physiological mechanisms lipid accumulations and will be...
Although several murine mAbs that have been humanized became useful therapeutic agents against a few malignancies, Abs are not yet available for the majority of human cancers because our lack knowledge which antigens (Ags) can become targets. In present study we established procedure comprehensive identification such Ags through extensive isolation may therapeutic. Using phage-display Ab library isolated large number bind to surface tumor cells. They were individually screened by...
Summary Background and objectives Nonlinear measures of heart rate variability (HRV) have gained recent interest as powerful risk predictors in various clinical settings. This study examined whether they improve stratification hemodialysis patients. Design, setting, participants, & measurements To assess turbulence, deceleration capacity, fractal scaling exponent (α 1 ), other conventional HRV measures, 281 patients underwent 24-hour electrocardiography between January 2002 May 2004 were...
Abstract A copper hydride cluster [Cu 8 (μ‐H) 6 (μ‐dppm) 5 ](PF ) 2 (dppm=bis(diphenylphosphino)methane) was prepared from reaction of [CuH(PPh 3 )] with dppm in the presence [Cu(CH CN) 4 ]PF and exhibited fluxional behaviors solution where hydrides phosphines are scrambling around trans ‐bicapped octahedral Cu framework. The H complex showed facile reactivity CO (1 atm, RT) to afford a tricopper complex, (μ‐H)(μ‐O CH)(μ‐dppm) , which could be developed unprecedented hydrosilylation...
Abstract Background Regulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other are relatively unaware of these due to the language barrier. This article aims describe compare relevant regulatory frameworks, using (more familiar) situation England as a point reference. We undertook literature reviews ascertain legal positions LST Korea, Taiwan, England. Main text Findings from review first presented development...
Abstract Secretion of acid phosphatase (APase) from the roots to take up phosphorus (P) is a well-known strategy plants under P-deficient conditions. White lupin, which shows vigorous growth in low-P soils, noted for its ability secrete APase The secreted by white lupin stable soil solution and low substrate specificity, suggesting that genetic modification using gene LASAP2 might improve their use organic P. objective present study was evaluate potential transgenic increase P utilization....
In an attempt to identify autoantigens of synovium in rheumatoid arthritis (RA), we constructed lambda phage expression cDNA libraries from and screened them by IgG purified synovial fluids, both which were derived RA patients. As a result this unique combination the probes, cloned follistatin-related protein (FRP) as novel autoantigen systemic rheumatic diseases. FRP is secreted containing similar amino acid sequence follistatin, inhibitor activin. was first transforming growth...
Adrenomedullin is a novel hypotensive peptide recently discovered in human pheochromocytoma. In the present study, we measured plasma immunoreactive adrenomedullin of healthy subjects and patients with various diseases. Immunoreactive was found to circulate blood at considerable concentration (3.3±0.3 fmol/ml). Plasma significantly increased congestive heart failure (5.4±0.3 fmol/ml), essential hypertension (5.3±0.4 fmol/ml) renal disease (4.9±0.4 fniol/ml). volunteers physical exercise...