A5016358274- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Research Data Management Practices
- Scientific Computing and Data Management
- Biomedical Text Mining and Ontologies
- Genetics, Bioinformatics, and Biomedical Research
- Diabetes Treatment and Management
- Genomics and Phylogenetic Studies
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Geochemistry and Geologic Mapping
- Pneumocystis jirovecii pneumonia detection and treatment
- Adenosine and Purinergic Signaling
- Biomedical and Engineering Education
- Protease and Inhibitor Mechanisms
- Genomics and Rare Diseases
- Biochemical and Structural Characterization
- Astronomical Observations and Instrumentation
- Science, Research, and Medicine
- Pancreatic function and diabetes
- Microbial Community Ecology and Physiology
- Protein Hydrolysis and Bioactive Peptides
- Biotechnology and Related Fields
- Biosimilars and Bioanalytical Methods
- Bioinformatics and Genomic Networks
Vlaams Instituut voor Biotechnologie
2024
SIB Swiss Institute of Bioinformatics
2016-2021
University of Lausanne
2017
University of Antwerp
1998-2003
Euroscreen (Belgium)
2001
KU Leuven
2001
Université Libre de Bruxelles
2001
Rega Institute for Medical Research
2001
Brigham and Women's Hospital
1998
Harvard University
1998
Abstract The SIB Swiss Institute of Bioinformatics (https://www.sib.swiss) creates, maintains and disseminates a portfolio reliable state-of-the-art bioinformatics services resources for the storage, analysis interpretation biological data. Through Expasy (https://www.expasy.org), Resource Portal, scientific community worldwide, freely accesses more than 160 supporting wide range life science biomedical research areas. In 2020, was redesigned through user-centric approach, known as...
Chemokines coordinate many aspects of leukocyte migration. As chemoattractants they play an important role in the innate and acquired immune response. There is good experimental evidence that N-terminal truncation by secreted or cell surface proteases a way modulating chemokine action. The localization CD26/dipeptidyl peptidase IV on surfaces biological fluids, its primary specificity, type naturally occurring truncated chemokines are consistent with such function. We determined steady-state...
Dipeptidyl peptidase IV (DPPIV, EC 3.4.14.5) is a serine type protease with an important modulatory activity on number of chemokines, neuropeptides and peptide hormones. It also known as CD26 or adenosine deaminase (ADA; 3.5.4.4) binding protein. DPPIV has been demonstrated the plasmamembranes T cells activated natural killer B well endothelial differentiated epithelial cells. A soluble form CD26/DPPIV described in serum. Over past few years, several related enzymes similar dipeptidyl have...
The chemokine stromal‐cell‐derived factor‐1α (SDF‐1α) chemoattracts lymphocytes and CD34 + haematopoietic progenitors is the ligand for CXCR4 (CXC receptor 4), main co‐receptor T‐tropic HIV‐1 strains. SDF‐1α was NH 2 ‐terminally cleaved to SDF‐1α(3‐68) by dipeptidyl‐peptidase IV (CD26/DPP IV), which present in blood soluble membrane‐bound form. lost both lymphocyte chemotactic CXCR4‐signaling properties. However, still desensitized SDF‐1α(1‐68)‐induced Ca 2+ response. In contrast CD26/DPP...
<ns4:p>The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart this are data resources, tools services that offers life-sciences community, providing access data. aims ensure these resources available long-term life-cycles managed such they support scientific needs life-sciences, including research.</ns4:p><ns4:p> </ns4:p><ns4:p> Core Data Resources defined as set European fundamental importance wider life-science...
Supplementary data are available at Bioinformatics online.
Dipeptidyl‐peptidase IV (DPPIV/CD26) metabolizes neuropeptides regulating insulin secretion. We studied the in vitro steady‐state kinetics of DPPIV/CD26‐mediated truncation vasoactive intestinal peptide (VIP), pituitary adenylyl cyclase‐activating (PACAP27 and PACAP38), gastrin‐releasing (GRP) neuropeptide Y (NPY). DPPIV/CD26 sequentially cleaves off two dipeptides VIP, PACAP27, PACAP38 GRP. GRP situates between best substrates reported, comparable to NPY. Surprisingly, C‐terminal extension...
<ns4:p>The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart this are data resources, tools services that offers life-sciences community, providing access data. aims ensure these resources available long-term life-cycles managed such they support scientific needs life-sciences, including research.</ns4:p><ns4:p> </ns4:p><ns4:p> Core Data Resources defined as set European fundamental importance wider life-science...
A new inter-governmental research infrastructure, ELIXIR, aims to unify bioinformatics resources and life science data across Europe, thereby facilitating their mining (re-)use.
In blood, the exopeptidase dipeptidyl-peptidase IV (DPPIV; EC 3.4.14.5) is predominantly present in a soluble form plasma/serum and as an activation antigen on membrane of lymphocytes (CD26). It modifies some important biologically active peptides (neuropeptides, chemokines), regulatory role for DPPIV/CD26 immune endocrine processes has been demonstrated. The aim this study was to determine reference values DPPIV activity association with series biochemical hematological parameters baseline...
<ns4:p>Millions of life scientists across the world rely on bioinformatics data resources for their research projects. Data can be very expensive, especially those with a high added value as expert-curated knowledgebases. Despite increasing need such highly accurate and reliable sources scientific information, most them do not have secured funding over near future often depend short-term grants that are much shorter than planning horizon. Additionally, they evaluated projects rather...
Millions of life scientists across the world rely on bioinformatics data resources for their research projects. Data can be very expensive, especially those with a high added value as expert-curated knowledgebases. Despite increasing need such highly accurate and reliable sources scientific information, most them do not have secured funding over near future often depend short-term grants that are much shorter than planning horizon. Additionally, they evaluated projects rather infrastructure...
Switzerland has been a pioneer in the field of bioinformatics since early 1980s. As time passed, need for one entity to gather and represent on national scale was felt and, 1998, SIB Swiss Institute Bioinformatics created. Hence, 2018 marks Institute's 20th anniversary. Today, federates 65 research service groups across country—whose activity domains range from genomics, proteomics, medicine health structural biology, systems phylogeny evolution—and group whose sole task is dedicated...
On November 18-19, 2016, the Human Frontier Science Program Organization (HFSPO) hosted a meeting of senior managers key data resources and leaders several major funding organizations to discuss challenges associated with sustaining biological biomedical (i.e., life sciences) infrastructure. A strong consensus emerged from group that core for sciences should be supported through coordinated international effort(s) better ensure long-term sustainability appropriately align scientific impact....
Abstract Motivation Life science research in academia, industry, agriculture, and the health sector depends critically on free open data resources. ELIXIR ( www.elixir-europe.org ), European Research Infrastructure for life sciences data, has identified a set of Core Data Resources within Europe that are most fundamental importance long-term preservation biological data. We explore characteristics their usage, impact assured funding horizon to assess value as an infrastructure, understand...