Abstract When faced with potential threat we must estimate its probability, respond advantageously, and leverage experience to update future estimates. Threat estimation is the proposed domain of forebrain, while behaviour elicited by brainstem. Yet, brainstem also a source prediction error, learning signal acquire Neuropixels probes allowed us record single-unit activity across 21-region axis in rats receiving probabilistic fear discrimination foot shock outcome. Against backdrop diffuse...

Trial-based theories of associative learning propose that is sensitive to the probability reinforcement signaled by a conditioned stimulus (CS). Learning, however, often rate rather than per trial, suggesting temporal properties cues may be more important trial-based properties. In four experiments, role trial was examined in appetitive Pavlovian conditioning mice under conditions which controlled. Experiments 1 and 2 loss responding caused overexpectation reinforcement. The failed affect...

While palatability depends on the properties of particular foods, it is also determined by prior experience, suggesting that memory affects hedonic value a substance. Here, we report two procedures affect in mice: negative contrast and flavour habituation. A microstructure analysis licking behaviour was employed, with lick cluster size (the number licks made quick succession before pause) used as measure palatability. It first confirmed increased monotonically function sucrose concentration,...

Consumption of foods results in a transient reduction hedonic value that influences the extent and nature feeding behavior. The time course this effect, however, is poorly specified. In an initial experiment, using analysis microstructure licking mice we found consumption sucrose led to rapid lick cluster size, measure palatability, which recovered after 10 min, but reemerged 60min consumption. We then replicated finding size reduced 60min, not 10min, under conditions number potential...

Abstract The hippocampus has been implicated in temporal learning. Plasticity within the requires NMDA receptor‐dependent glutamatergic neurotransmission. We tested prediction that hippocampal receptors are required for learning about time by testing mice lack postembryonal NMDARs CA1 and dentate gyrus (DG) subfields on three different appetitive procedures. conditional knockout ( Grin1 ΔDCA1 ) showed normal sensitivity to cue duration, responding at a higher level short duration than...

The GluA1 subunit of the AMPA receptor has been implicated in anhedonia. Mice that lack (Gria1 knockout mice) show reduced lick cluster size, a measure palatability feeding behaviour. This deficit may reflect role for encoding hedonic value palatable substances or instead behavioural expression value. We tested by assessing sensitivity to changes rewarding property sucrose as consequence negative/positive contrast effects female mice. During training, on half days consumption flavour (CS+)...

Abstract When faced with potential threat we must estimate its probability, respond advantageously, and leverage experience to update future estimates. Threat estimates are the proposed domain of forebrain, while behaviour is elicited by brainstem. Yet, brainstem also a source prediction error, learning signal acquire Neuropixels probes allowed us record single-unit activity across 21-region axis during probabilistic fear discrimination foot shock outcome. Against backdrop diffuse signaling,...