A5103237936- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- Polymer Surface Interaction Studies
- Drug Transport and Resistance Mechanisms
- Lanthanide and Transition Metal Complexes
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Radiopharmaceutical Chemistry and Applications
- ATP Synthase and ATPases Research
- Advanced Polymer Synthesis and Characterization
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Surfactants and Colloidal Systems
- Nanoparticles: synthesis and applications
- Characterization and Applications of Magnetic Nanoparticles
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
Northeastern University
2016-2025
Boston University
2008-2024
Eastern University
2015-2024
Sechenov University
2019-2021
Universidad del Noreste
2019-2021
National Institutes of Health
2008-2020
Yale University
2020
Harvard University
1992-2020
Rockefeller University
2020
Brigham and Women's Hospital
2020
To prepare immunomicelles, new targeted carriers for poorly soluble pharmaceuticals, a procedure has been developed to chemically attach mAbs reactive groups incorporated into the corona of polymeric micelles made polyethylene glycol-phosphatidylethanolamine conjugates. Micelle-attached antibodies retained their ability specifically interact with antigens. Immunomicelles attached antitumor mAb 2C5 effectively recognized and bound various cancer cells in vitro showed an increased accumulation...
To develop targeted pharmaceutical carriers additionally capable of responding to certain local stimuli, such as decreased pH values in tumors or infarcts, long-circulating PEGylated liposomes and PEG-phosphatidylethanolamine (PEG-PE)-based micelles have been prepared with several functions. First, they are targeting a specific cell organ by attaching the monoclonal antimyosin antibody 2G4 their surface via pNP-PEG-PE moieties. Second, these were modified biotin TAT peptide (TATp) moieties...
A novel "smart" multifunctional drug delivery system was successfully developed to respond the up-regulated matrix metalloprotease 2 (MMP2) in tumor microenvironment and improve cancer cell-specific of loaded drugs. The represents a surface-functionalized liposomal nanocarrier, for which two functional polyethylene glycol (PEG)-lipid conjugates were synthesized characterized. functionalized liposome further modified with antinucleosome monoclonal antibody (mAb 2C5). In resulting system,...
Significance The clinical outcomes of anticancer drugs are compromised by their poor physicochemical properties, low tumor targeting, insufficient bioavailability, and side effects. Matrix metalloproteinase 2 (MMP2) has been found overexpressed in most cancers responsible for cell proliferation metastasis. In this study, a self-assembling MMP2-sensitive paclitaxel-containing micellar nanopreparation was developed. Several major drug delivery strategies, including self-assembly, PEGylation,...
Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades. They significant advantages over their free forms in terms pharmacokinetics, sensitivity cancer diagnosis efficacy. The multifactorial nature complex physiology tumor microenvironment require development multifunctional nanocarriers. Multifunctional liposomal nanocarriers should combine long blood circulation improve pharmacokinetics loaded agent...