A5017162700- Bone Metabolism and Diseases
- Cardiovascular Effects of Exercise
- Bone health and osteoporosis research
- Cardiovascular Function and Risk Factors
- Bone health and treatments
- Fish Ecology and Management Studies
- Medical Imaging Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Sports injuries and prevention
- Fish Biology and Ecology Studies
- Bone and Joint Diseases
- Cardiac Imaging and Diagnostics
- Marine and fisheries research
- Genetic Syndromes and Imprinting
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Genetic and Kidney Cyst Diseases
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Forensic Anthropology and Bioarchaeology Studies
- Wnt/β-catenin signaling in development and cancer
- Connective tissue disorders research
- Medical Imaging and Pathology Studies
- Paleopathology and ancient diseases
- Radiopharmaceutical Chemistry and Applications
Martin Luther University Halle-Wittenberg
2023-2025
Rome Foundation
2018
Universität Hamburg
2007-2017
University Medical Center Hamburg-Eppendorf
2007-2017
In-Q-Tel
2014
Springer Nature (Germany)
2014
Pfizer (Germany)
2014
Huazhong University of Science and Technology
2012
Universität Ulm
2012
Tongji Hospital
2012
Although Wnt signaling in osteoblasts is of critical importance for the regulation bone remodeling, it not yet known which specific receptors Frizzled family are functionally relevant this process. In paper, we show that Fzd9 induced upon osteoblast differentiation and Fzd9−/− mice display low mass caused by impaired formation. Our analysis primary demonstrated defects matrix mineralization spite normal expression established markers. contrast, observed a reduced chemokines...
Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators this Dkk1, which antagonizes through ternary complex with transmembrane receptors Krm1/2 Lrp5/6, thereby blocking induction by latter ones. Here we show that Kremen-2 (Krm2) predominantly expressed bone, its osteoblast-specific over-expression transgenic (Col1a1-Krm2) results severe osteoporosis. Histomorphometric analysis revealed osteoblast maturation are disturbed Col1a1-Krm2 mice, whereas...
Abstract Background Spinal pain, one of the most common musculoskeletal disorders (MSDs), significantly impacts quality life due to chronic pain and disability. Physical activity has shown promise in managing spinal although optimizing adherence exercise remains a challenge. The digital development artificial intelligence (AI)-driven applications offers possibility for guiding supporting patients with MSDs their daily lives. Objective trial aimed investigate effect an 8-week AI-composed...
Research Article15 October 2013Open Access Decreased bone formation and increased osteoclastogenesis cause loss in mucolipidosis II Katrin Kollmann Department of Biochemistry, Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Search for more papers by this author Jan Malte Pestka Osteology Biomechanics, Experimental Medicine, Sonja Christin Kühn Elisabeth Schöne Michaela Schweizer Electron Microscopy, Molecular Neurobiology, Kathrin Karkmann Takanobu Otomo...
Alström syndrome (AS) is a rare autosomal recessive ciliopathy with wide spectrum of clinical features, including cone-rod retinal dystrophy, neuronal deafness, severe insulin resistance and major organ failure. The characteristics renal disease in the have not been systematically described. aim this study to define onset progression AS.Prospective observational cohort study.Thirty-two adult subjects from national specialist clinic UK 86 an international AS registry were studied.First,...
Abstract The primary role of apolipoprotein E (apoE) is to mediate the cellular uptake lipoproteins. However, a new for apoE as regulator bone metabolism in mice has recently been established. In contrast mice, human APOE gene characterized by three common isoforms ε2, ε3, and ε4 that result different metabolic properties isoforms, but it remains controversial whether polymorphism influences traits humans. To clarify this, we investigated phenotypes knock-in (k.i.) which express one isoform...
Midkine (Mdk) and pleiotrophin (Ptn) comprise a family of heparin-binding growth factors known primarily for their effects on neuronal cells. Since transgenic mice overexpressing Ptn have been reported to display increased bone density, we previously analyzed Ptn-deficient but failed detect any abnormality skeletal development remodeling. Together with the finding that Mdk expression increases in course primary osteoblast differentiation, reasoned Mdk, rather than Ptn, could play physiologic...
Postmenopausal osteoporosis is characterized by declining estrogen levels, and replacement therapy has been proven beneficial for preventing bone loss in affected women. While the physiological functions of bone, primarily inhibition resorption, have studied extensively, effects pharmacological administration are still poorly characterized. Since elevated levels follicle-stimulating hormone (FSH) suggested to be involved postmenopausal loss, we investigated whether skeletal response mediated...
European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from fresh waters through the North Atlantic Ocean to Sargasso Sea. Along with sexual maturation, eel skeleton undergoes a remarkable morphological transformation during migration, where hitherto completely obscure bone loss phenomenon occurs. To unravel mechanisms of maturation-related decay skeleton, we performed multiscale assessment eels' bones at different life-cycle stages. Accordingly, reflects extensive...
The aim of this study was the registration digitized thin 2D sections mouse vertebrae and tibiae used for histomorphometry trabecular bone structure into 3D micro computed tomography (μCT) datasets samples from which were prepared. Intensity-based segmentation-based registrations (SegRegs) μCT applied. As deformed during their preparation, affine instead rigid registration. Tibiae additionally cut on distal end, subsequently undergone more deformation so that elastic necessary. Jaccard...