A5103243984- Chemical Synthesis and Analysis
- Arsenic contamination and mitigation
- Heavy metals in environment
- Heavy Metals in Plants
- Analysis of environmental and stochastic processes
- Mine drainage and remediation techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuropeptides and Animal Physiology
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Protein Structure and Dynamics
- Pharmacological Receptor Mechanisms and Effects
- Chemistry and Chemical Engineering
- Coordination Chemistry and Organometallics
- Metal Extraction and Bioleaching
- Click Chemistry and Applications
- Plant Ecology and Soil Science
- Migraine and Headache Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemical Reaction Mechanisms
- Heavy Metal Exposure and Toxicity
- Carbohydrate Chemistry and Synthesis
- Cyclopropane Reaction Mechanisms
China Agricultural University
2022
Bristol-Myers Squibb (United States)
2012-2021
Central South University
2017
University of Concepción
1997
Metal mining and waste discharge lead to regional heavy metal contamination attract major concern because of the potential risk local residents. This research was conducted determine (Pb), cadmium (Cd), arsenic (As), manganese (Mn), antimony (Sb) concentrations in soil brown rice samples from three areas Hunan Province, central China, assess health risks inhabitants. Local observed, with mean Cd, Pb, Sb, As 0.472, 193.133, 36.793, 89.029 mg/kg, respectively. Mean Mn, were 0.103, 0.131,...
The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. features several highly efficient telescoped processes use Evans auxiliary to install a methyl-bearing stereocenter. target was prepared in 12 steps with 7 isolations an overall yield 31%.
An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new showcases a chemo- and reduction cyclohepta[b]pyridine-5,9-dione as well Pd-catalyzed alpha-arylation reaction form key carbon-carbon bond set absolute relative stereochemistry.
Two efficient asymmetric routes to γ-secretase modulator BMS-932481, under investigation for Alzheimer's disease, have been developed. The key step the first route involves a challenging enantioselective hydrogenation of an unfunctionalized trisubstituted alkene establish benzylic stereocenter, representing very rare case achieving high selectivity on complex substrate. second demonstrates example vinylogous dynamic kinetic resolution (VDKR) ketone reduction, where carbonyl and racemizable...
A concise bulk synthesis of stereochemically complex CCR2 antagonist BMS-741672 is reported. distinct structural feature the chiral all-cis 1,2,4-triaminocyclohexane (TACH) core, which was assembled through consecutive stereocontrolled heterogeneous hydrogenations: efficient Pt-catalyzed reduction a β-enaminoester, directed by (S)-α-methylbenzylamine as low-cost template, and reductive amination 3,4-cis-disubstituted cyclohexanone over sulfided Pt/C introduced tert-amine, setting third...
The classical preparation of 3-methyl-1-aryl-1,2,4-triazoles through an SNAr reaction pathway results in a mixture N-regioisomers. Removal the unwanted isomer reduces yield and affects processability final product. In presented case study, target triazole was prepared by route over three steps, 24% overall yield, with prohibitive Process Mass Index (PMI) 300 that made inadequate for process scale implementation. Bristol-Myers Squibb scientists discovered improved strategy allows access to...
BMS-813160 is a pharmaceutical entity currently in development at Bristol Myers Squibb. Its defining structural feature unique chiral all cis triamino cyclohexane core. Medicinal and process chemistry groups BMS have previously published synthesis strategies for chemotypes similar to the target molecule, but streamlined approach amenable longer-term supply was necessary. A new synthetic route conceptualized, experimentally investigated, determined meet criteria efficiency that addressed key...
Rice can potentially pose serious health risks due to its highly efficient arsenic (As) uptake. Sulfur (S) is not only an essential macronutrient, but it also has the ability decrease As accumulation. In present study, a hydroponic experiment was conducted investigate mechanisms underlying effects of S on uptake and transport with different (pre-)treatments levels. The results showed extra decreased content by 20-50% in both S-deficiency S-normal pre-treated shoots compared no supply...