A5103240534- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- NF-κB Signaling Pathways
- Cardiac electrophysiology and arrhythmias
- Cell death mechanisms and regulation
- Ion channel regulation and function
- Underground infrastructure and sustainability
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Smart Materials for Construction
- Prostate Cancer Treatment and Research
- Muscle Physiology and Disorders
- International Relations in Latin America
- Cancer, Lipids, and Metabolism
- Health, Environment, Cognitive Aging
- Ion Channels and Receptors
- Redox biology and oxidative stress
- Hearing, Cochlea, Tinnitus, Genetics
- PARP inhibition in cancer therapy
European Molecular Biology Organization
2022-2023
University of North Carolina at Chapel Hill
2022
University of Rochester
2019-2022
University of Rochester Medical Center
2022
Cardiovascular Institute Hospital
2019
The University of Texas Southwestern Medical Center
2014-2016
University of Colorado Boulder
2015
Lund University
2007
Rush University
2001
Rush University Medical Center
1978-1999
A family of micropeptides inhibits calcium reuptake by the endoplasmic reticulum in diverse cell types.
BACKGROUND Products of the arachidonic acid-metabolizing enzyme, 5-lipoxygenase, stimulate growth several cell types. Selective inhibitors including SC41661A and MK886, reduce PC-3 prostate proliferation. With continued culture, cells die, but mode death, necrotic or nonnecrotic, has not been established. METHODS Flow cytometry, laddering after agarose electrophoresis DNA from inhibitor-treated cells, light electron microscopy were employed to examine type death in cultured with either...
Significance Disorders affecting neuromuscular tissues are among the most devastating human diseases, characterized by progressive loss of voluntary movement, muscle wasting, and premature death. Neurodegenerative disorders genetically heterogeneous, with disease-causing mutations still unidentified. Here we show that mice lacking zinc finger protein 106 (ZFP106) develop motor nerve atrophy degeneration die prematurely. We found ZFP106 is a skeletal muscle-enriched RNA-binding directly...
Post-transcriptional cleavage and polyadenylation of messenger long noncoding RNAs is coordinated by a supercomplex ~20 individual proteins within the eukaryotic nucleus 1,2 . Polyadenylation plays an essential role in controlling RNA transcript stability, nuclear export, translation efficiency 3–6 More than half all human transcripts contain multiple signal sequences that can undergo alternative during development cellular differentiation 7,8 Alternative important mechanism for control gene...
Human monogenetic diseases can arise from the aberrant expansion of tandem nucleotide repeat sequences, which when transcribed into RNA, misfold and aggregate toxic nuclear foci 1 . Nuclear retention repeat-containing RNAs disrupt their normal expression induce widespread splicing defects by sequestering essential RNA binding proteins. Among most prevalent these disorders is myotonic dystrophy type (DM1), a disease occurring noncoding CTG in 3’UTR human dystrophia myotonica protein kinase...
Cochlear implant (CI) recipients with normal or near hearing (NH) in the contralateral ear, referred to as single-sided deafness (SSD), experience significantly better speech recognition noise their CI than without it, although reported outcomes vary. One possible explanation for differences across studies could be spatial configurations used assess performance. This study compared different of target and masker, test materials clinically.Sixteen users SSD completed tasks masked presented...
The three major nuclear DNA-dependent RNA polymerases (enzymes I, II and III) were present in extracts from transplantable R-35 rat mammary tumors. Except for somewhat less enzyme III, their relative distribution resembled that of late-pregnant rats. When normal tissue was incubated synthesis with cyclic AMP, inhibition frequently observed, but this occurred often the tumor. In some experiments both tumor tissue, AMP GMP increased apparent activity nucleolar lb nucleoplasmic II,...