A5088137659- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- IL-33, ST2, and ILC Pathways
- Alcohol Consumption and Health Effects
- Genetic factors in colorectal cancer
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Cancer-related gene regulation
- Electrolyte and hormonal disorders
- Galectins and Cancer Biology
- Acoustic Wave Resonator Technologies
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Microwave Dielectric Ceramics Synthesis
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- ATP Synthase and ATPases Research
- Hepatitis B Virus Studies
Gauhati Medical College and Hospital
2016-2025
Aims: This study was designed to determine if vitamin D receptor (VDR), carrier globulin/binding protein (GC), and cytochrome P-450 family 2, subfamily R, polypeptide 1 (CYP2R1) gene polymorphisms are risk factors in the development of hepatocellular carcinoma (HCC) hepatitis C virus (HCV)-infected patients from Northeast India. Materials Methods: A total 351 HCV-infected were enrolled which 167 diagnosed with chronic (CHC), 124 liver cirrhosis (LC), 60 HCC together 102 age- sex-matched...
Promoter methylation reflects in the inactivation of different genes like O 6 -methylguanine-DNA methyltransferase DNA repair gene and runt-related transcription factor 3, a known tumor suppressor various cancers such as esophageal cancer. The promoter was evaluated for 3 CpG, CHH, CHG context (where H is A, T, or C) by next-generation sequencing. status correlated with quantitative messenger RNA expression. In addition, expression risk factors tobacco, alcohol, betel nut consumption,...
Chronic hepatitis C virus (HCV) infection leads to variable outcomes, ranging from prolonged slow hepatic damage leading cirrhosis, and hepatocellular carcinoma (HCC). Polymorphism in cytokines IL-10 IL-12 that impact the immune response HCV may play a role determining this outcome. This study was aimed determine if polymorphisms IL-12B contribute susceptibility risk of developing HCC patients Northeast India. - 1082, -819, -592 -1188 were genotyped by polymerase chain reaction-restriction...
Background: To investigate polymorphisms in heat shock proteins A1B and A1L (HOM) associated risk of oesophageal carcinoma Northeast India.Materials Methods: The study includes cancer (ECA) patients attending general outpatient department (OPD) endoscopic unit Gauhati Medical College.Patients were diagnosed based on histopathological findings.Genomic DNA was typed for HSPA1B1267 HSPA1L2437 SNPs using the polymerase chain reaction with restriction fragment length polymorphisms.Results: A...
Introduction: Toxic hepatitis refers to the inflammation of liver that may follow on inhalation, ingestion or parenteral administration a number pharmacological and chemical agents. The traditional knowledge ethnic tribal people using plants as herbal medicine has become very significant gives both positive negative impact in treatments diseases. A pilot study been conducted among locality Assam, India during year 2016-17. local practitioners (locally known “Bez” “Ojha”) were providers...
Abstract Background Interleukin-8 (IL8), Interleukin-12 (IL12) and Interleukin-13 (IL13) are cytokines that play regulatory role in cancer pathogenesis. We analysed their expression profile to evaluate as molecular biomarkers of esophageal squamous cell carcinoma (ESCC) association with different parameters. Methods Expression analysis IL8, IL12 IL13 were performed by Real time qPCR blood tumor tissue 120 ESCC patients. The profiles associated clinicopathological dietary factors. Survival...
Background: The microRNA (miRNA) mediated translational repression can cause various diseases in humans. liver-specific miRNA (microRNA-122 (miR-122)) is primarily involved tissue tropism during hepatitis C virus (HCV) infection which ultimately leads to hepatocellular carcinoma (HCC). Objectives: This study focuses on evaluating host serum miR-122 as a prognostic marker HCV-induced carcinoma. Methods: Evaluation of expression was carried out by quantitative real time PCR. Results: Positive...
Introduction: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision pathway, as scaffold protein that brings together proteins of DNA complex. XRCC1 is reported to be candidate influence on cancer risk. Oesophageal Cancer (EC) eighth common type worldwide and sixth cause related deaths world [Zhang et. al., 2009]. The aim our present study was assess association rs1799782 (Arg194Trp), rs25489 (Arg280His) rs25487 (Arg399Gln) gene polymorphisms with oesophageal...
Introduction: Promoter methylation results in the alteration of different gene expressions such as like O6-methylguanine-DNA methyltransferase (MGMT) and Runt-related transcription factor 3 (RUNX3) various cancers oesophageal cancer (EC). MGMT is a DNA repair enzyme RUNX3 novel tumor suppressor gene. CpG In this study, we analyzed status promoters (EC) to evaluate relationship between expression EC. Methods: A total 80 EC tissue samples were for promoter by methylation-specific polymerase...
Abstract The features of translational repression by micro-RNA can cause various diseases in humans. liver-specific microRNA (mir122) is primarily involved tissue tropism during HCV infection. This study focuses on evaluating host serum miR-122 as a prognostic marker A positive expression was observed CHC patients followed HCC compared to healthy controls. difference median levels and (p < 0.000) found contrast Cirrhosis = 0.511). threefold higher liver cirrhosis than chronic hepatitis....
Background: Data regarding Acute on Chronic Liver Failure (ACLF) patients from North East India is scarce and presentation to hospital often late. We aim study their clinical profile, aetiology of underlying chronic liver disease, precipitating factors, predictors mortality short term outcome (3 months).Methods: Among 1000 consecutive any form acute decompensation, 245 diagnosed as ACLF were prospectively studied. Comparison was done between survivors versus non Non patients.Results: Mean...