A5062758599- Cellular Mechanics and Interactions
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Nuclear Structure and Function
- Ovarian function and disorders
- Cellular transport and secretion
- Plant Reproductive Biology
- Neurological diseases and metabolism
- RNA Research and Splicing
- Calpain Protease Function and Regulation
- Neurogenesis and neuroplasticity mechanisms
- DNA and Nucleic Acid Chemistry
- Microtubule and mitosis dynamics
- Hypothalamic control of reproductive hormones
University of Genoa
2024
University of Turin
2021-2022
1. Abstract Findings accumulated over time show that neurophysiological, neuropathological, and molecular alterations are present in CMT1A support the dysmyelinating rather than demyelinating nature of this neuropathy. Moreover, uniform slowing nerve conduction velocity is already manifest children does not improve throughout their life. This evidence our previous studies displaying aberrant myelin composition structure adult rats prompt us to hypothesize a axon developmental defect...
Current technologies for precise genetic manipulation of cells often utilize site-specific recombinases, enabling the creation conditional transgenic models studying gene functions in specific tissues and at defined time windows. The advent drug-inducible recombinases has further enhanced this field by allowing temporal control expression. However, detecting expression patterns when multiple are used is challenging, particularly visualizing combinatorial maps their profile. To address this,...
Findings accumulated over time show that neurophysiological, neuropathological, and molecular alterations are present in CMT1A support the dysmyelinating rather than demyelinating nature of this neuropathy. Moreover, uniform slowing nerve conduction velocity is already manifest children does not improve throughout their life. This evidence our previous studies displaying aberrant myelin composition structure adult rats prompt us to hypothesize a axon developmental defect peripheral nervous...
Recessively inherited limb-girdle muscular dystrophy type 1, caused by mutations in the calpain 3 gene, is most common worldwide. Recently, cases of autosomal dominant calpainopathy have been described. A man was referred to our neurological outpatient clinic at age 54 for persistent hyperCKemia (>1000 U/l) associated with muscle fatigue and myalgia. Clinical examination revealed mild proximal weakness lower limbs. His brother exhibited a moderate increase serum creatine kinase levels (up...
GTPases of the Rho family are components signaling pathways linking extracellular signals to control cytoskeleton dynamics. Among these, RAC1 plays key roles during brain development, ranging from neuronal migration neuritogenesis, synaptogenesis, and plasticity. activity is positively negatively controlled by guanine nucleotide exchange factors (GEFs), guanosine dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), but specific role each regulator in vivo poorly known. ARHGAP15...
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in mouse brain, participating several pre- and post-synaptic mechanisms. p140Cap knock-out (KO) female mice show severe hypofertility, delayed puberty onset, altered estrus cycle, reduced ovulation, defective production of luteinizing hormone estradiol during proestrus. We investigated role development maturation hypothalamic gonadotropic system. During embryonic...