A5033511837- Traffic Prediction and Management Techniques
- Traffic and Road Safety
- Traffic control and management
- Transportation Planning and Optimization
- Infrastructure Maintenance and Monitoring
- Immunotherapy and Immune Responses
- Diatoms and Algae Research
- Immune Response and Inflammation
- Forensic Fingerprint Detection Methods
- Maritime Ports and Logistics
- Transportation Safety and Impact Analysis
- Inhalation and Respiratory Drug Delivery
- Urban and Freight Transport Logistics
- SARS-CoV-2 and COVID-19 Research
- Occupational Health and Safety Research
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- Global trade and economics
- Advanced Nanomaterials in Catalysis
- Forensic and Genetic Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Economic and Environmental Valuation
- Vehicle Dynamics and Control Systems
- Antimicrobial Peptides and Activities
University of Montana
2020-2024
Georgia State University
2017-2020
Cairo University
2020
Isra University
1997-1998
Ministry of Transportation of Ontario
1995
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) , is one of the top infectious killers in world. The only licensed vaccine against TB, Bacille Calmette-Guérin (BCG), provides variable protection pulmonary especially adults. Hence, novel TB approaches are urgently needed. Both Th1 and Th17 responses necessary for yet effective adjuvants delivery systems inducing robust immunity lacking. Herein we describe a synthetic Mincle agonist, UM-1098, silica nanoparticle system...
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve efficacy safety profiles vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery platform for TLR7/8 agonists along with recombinant influenza antigen hemagglutinin H7 (H7) APCs. A-SNP two different sizes (50 200 nm) were prepared coated INI-4001 at coating densities, followed by co-adsorption H7. Both showed >90% adsorption tested...
This paper describes a method to identify accident-prone locations (APLs) based on an assessment of factors that contribute accidents. Current methods APLs make no distinction between accidents result from road- and nonroad-related factors. Combining are treatable nontreatable by road improvements can be misleading may lead misallocation funds authorities. presents computerized procedure uses safety experts' knowledge classifying into finite set categories. In practice, the categories...
Adjuvants and immunomodulators that effectively drive a Th17-skewed immune response are not part of the standard vaccine toolkit. Vaccine adjuvants delivery technologies can induce Th17 or Th1/17 immunity protection against bacterial pathogens, such as tuberculosis (TB), urgently needed. Th17-polarized be induced using agonists bind activate C-type lectin receptors (CLRs) macrophage inducible (Mincle). A simple but effective strategy was developed for codelivering Mincle with recombinant...
This paper investigates the classification of road accidents using neural networks and fuzzy techniques. Accident correctability by improvements has been advocated as an important criterion in identification accident-prone locations. Sayed et al. (1995) described a method to identify accident algorithm (fuzzy K-nearest neighbors). The used safety experts' knowledge classify according their contributing factors causes into three road-system components (the vehicle, driver, environment)....
The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, therefore represents promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pharmacology potency may prove useful the development of Th17-mediated adaptive responses. Herein, we report on vitro silico investigations specific ligand–receptor interactions required effective engagement activation Th17-polarizing cytokines....
The main objective of this paper is to introduce a systematic approach determine the need for and location truck escape ramps (TERs). utilizes variables concerning design vehicle, road, driver. These are included in either stochastic or deterministic form. Vehicle include vehicle type, gross weight, brake type. Road profile (length steepness grade), horizontal curvature (cornering speed), availability brake-check area at top grade. Driver information about driver's actions area, checking,...
Accident prone locations are traditionally defined as that exhibit higher accident occurrence (frequency and severity) than an established norm. This definition represents the foundation on which Black Spot programs for safety improvements executed. paper extends of by examining not only frequency severity but also their patterns. It is argued a location with given number accidents well-defined patterns can be treated more effectively larger poorly Traditional approaches start problem (high...
Despite the availability of effective vaccines against COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide, pressing need for new with improved breadth and durability. We developed an adjuvanted subunit vaccine SARS-CoV-2 using recombinant receptor-binding domain (RBD) spike synthetic adjuvants targeting TLR7/8 (INI-4001) TLR4 (INI-2002), co-delivered aluminum hydroxide (AH) or phosphate (AP). The formulations were characterized quantities...
This paper examines the safety impact of access type, density, traffic volume, and road geometry on two-lane rural highways in British Columbia. Documented accident to relationships were reviewed found be poor agreement with observed experience within Province. The nontransferability relationships, lack studies interaction effects, need for a tool predict highway led development models described this paper. A comprehensive disaggregate data base was constructed some 560 km provincial primary...
Despite the availability of effective vaccines against COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide, pressing need for new with improved breadth and durability. We developed an adjuvanted subunit vaccine SARS-CoV-2 using recombinant receptor–binding domain (RBD) spikes synthetic adjuvants targeting TLR7/8 (INI-4001) TLR4 (INI-2002), co-delivered aluminum hydroxide (AH) or phosphate (AP). The formulations were characterized quantities...
In traditional black-spot programs aimed at improving highway safety, locations are identified as accident prone based on the total number of accidents. This criteria provides no consideration whether accidents were caused or could be corrected by road improvements. method results in identification that not truly hazardous from a road-safety authority perspective and consequently may lead to misapplication safety improvement funding. Therefore, should categorized into one combination three...
Abstract Powassan virus (POWV) is a pathogenic tick-borne flavivirus that causes fatal neuroinvasive disease in humans. There are currently no approved therapies or vaccines for POWV infection. Here, we develop POW virus-like-particle (POW-VLP) based vaccine adjuvanted with the novel synthetic Toll-like receptor 7/8 agonist INI-4001. We demonstrate INI-4001 outperforms both alum and 4 INI-2002 enhancing immunogenicity of dose-sparing POW-VLP mice. increases magnitude breadth antibody...
This paper reports and discusses the results of an effort to develop disaggregate behavioral mode choice models intercity travel in Canada. Currently available data bases Canada are reviewed. The feasibility using from national surveys statistically reliable is examined, directions for future collection efforts offered. developed multinomial logit (MNL) type which included all passenger modes: auto, air, bus, rail. For purposes estimation, market was segmented by trip length (short, long);...
Co-delivery of antigens and adjuvants to the same antigen presenting cells (APCs) can significantly improve efficacy safety profiles vaccines. Here, we report amine-grafted silica nanoparticles (A-SNPs) as a tunable vaccine co-delivery platform for TLR7/8 agonists along with recombinant influenza hemagglutinin H7 (H7) APCs. A-SNPs two different sizes (50 200 nm) were prepared coated INI-4001 at coating densities, followed by co-adsorption H7. Both showed > 90% adsorption tested...
Conventional statistical distribution models (e.g., Poisson) are known to perform satisfactorily in predicting the number of crossing opportunities a traffic stream certain characteristics. However, many studies, one is interested estimating under and roadway conditions that not typical any distribution. A example across two-way, multilane within signalized corridor. There does appear be single capable adequately describing vehicular headway variety conditions.This paper demonstrates...
The ability to accurately evaluate roadside hazards is very important highway safety officials and researchers, who are concerned with reducing the frequency, severity, ultimately, cost of “run‐off‐the‐road” accidents. environment in province British Columbia, Canada, contains many motorists due severe topographical characteristics, including steep embankment slopes numerous features that would cause harm if struck by a vehicle. This paper describes need hazardous locations outlining...