A5044734915- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- HIV Research and Treatment
- Malaria Research and Control
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
- Vector-borne infectious diseases
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Vectors
- Dermatology and Skin Diseases
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- T-cell and B-cell Immunology
- Insect symbiosis and bacterial influences
University of New Mexico
2024-2025
University of Alaska Anchorage
2018-2021
Vaccines that target the pre-erythrocytic stage of malaria lifecycle have potential to provide sterilizing immunity but must elicit sustained, high-titer antibody responses completely prevent infection. Most vaccines circumsporozoite protein (CSP), major surface antigen on Plasmodium falciparum sporozoites. Antibodies targeting distinct epitopes within central repeat region CSP protection from infection, we focused developing a highly vulnerable epitope is targeted by potent monoclonal L9....
ABSTRACT Malaria is a highly lethal infectious disease caused by Plasmodium parasites. These parasites are transmitted to vertebrate hosts when mosquitoes of the Anopheles genus probe for blood meal. Sporozoites, stage , transit liver within hours injection into dermis. Vaccine efforts hindered complexity parasite’s lifecycle and speed at which infection established in liver. In an effort enhance immunity against we produced virus-like particle (VLP)-based vaccine displaying epitope TRIO,...
Activation of antigen presenting cells (APCs) is necessary for immune recognition and elimination cancer. Our lab has developed a liposome nanoparticle that binds to complement C3 proteins present in serum. These C3-liposomes are specifically internalised by APCs other myeloid cells, which express C3-binding receptors. Known stimulating compounds, toll-like receptor (TLR) agonists, were encapsulated within the C3-liposomes, including monophosphoryl lipid A (MPLA), R848, CpG 1826, specific...
Complement C3-dependent uptake of targeted liposomes into human macrophages, B cells, dendritic neutrophils, and MDSCs Alexandra Francian,1 Kristine Mann,1,2 Max Kullberg1 1WWAMI Medical Education Program, 2Department Biological Sciences, University Alaska Anchorage, AK, USA Abstract: Antitumor immunity in cancer patients is heavily modulated by cells the innate immune system. Antigen-presenting including initiate recognition tumor antigen displaying to effector cells. Countering this...
In the tumor microenvironment, cytokines, growth factors, and oncogenes mediate constitutive activation of signal transducer activator transcription 3 (STAT3) signaling pathway in both cancer cells infiltrating immune cells. STAT3 drives tumorigenic changes that allow for increased survival, proliferation, resistance to apoptosis. The modulation is more complicated conflicting. myeloid cell phenotype towards an suppressive state, which mediates T inhibition. On other hand, leads...
Malaria is a highly lethal infectious disease caused by
Abstract Since its introduction, vaccination has heavily improved health outcomes. However, implementing efforts can be challenging, particularly in low and middle-income countries with warmer climates. Microneedle technology been developed for simple relatively painless applications of vaccines. no microneedle vaccine yet approved by the FDA. A few hurdles must overcome, including need to evaluate safety biocompatibility polymer used fabricate these microneedles. Additionally, it is...