A5101438928- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Protein Hydrolysis and Bioactive Peptides
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Aquaculture disease management and microbiota
- Biochemical and Structural Characterization
- Viral gastroenteritis research and epidemiology
- Antimicrobial agents and applications
- Viral Infections and Immunology Research
- Probiotics and Fermented Foods
- Coccidia and coccidiosis research
- Lipid Membrane Structure and Behavior
- Reproductive tract infections research
- Vector-Borne Animal Diseases
- vaccines and immunoinformatics approaches
- Phosphorus and nutrient management
- Agricultural and Biological Research
- Syphilis Diagnosis and Treatment
- RNA regulation and disease
- Marine Invertebrate Physiology and Ecology
- Inhalation and Respiratory Drug Delivery
- Microbial infections and disease research
- Yersinia bacterium, plague, ectoparasites research
- Microbial Fuel Cells and Bioremediation
Liaoning Ocean and Fisheries Research Institute
2025
Ministry of Agriculture and Rural Affairs
2025
Henan Institute of Science and Technology
2015-2025
Henan Agricultural University
2019-2023
Jiangsu University
2017
Changzhou University
2017
Southwest University
2016
Chinese Academy of Agricultural Sciences
2011-2013
Shanghai Veterinary Research Institute
2011-2013
Northwest A&F University
2009
With the emergence of many antibiotic-resistant strains worldwide, antimicrobial peptides (AMPs) are being evaluated as promising alternatives to conventional antibiotics. P3, a novel hemoglobin peptide derived from bovine erythrocytes, exhibited modest activity in vitro. We activities P3 and an analog, JH-3, both vitro vivo. The MICs JH-3 ranged 3.125 μg/ml 50 when wide spectrum bacteria was tested, including multidrug-resistant strains. killed within 30 min by disrupting bacterial...
Staphylococcus aureus is a common pathogen that can cause pneumonia and variety of skin diseases. Skin injuries have high risk colonization by S. aureus, which increases morbidity mortality. Due to the emergence multidrug-resistant strains, antimicrobial peptides are considered be among best alternatives antibiotics due their unique mechanism action other characteristics. MPX an antibacterial peptide extracted from wasp venom has activity against bacteria. This study revealed good...
A survey was conducted to evaluate the effectiveness of adaptive resolution imaging sonar (ARIS), also known as an acoustic camera, for monitoring large jellyfish in Liaodong Bay area, China. The abundance and vertical distribution species, such Nemopilema nomurai, Aurelia coerulea, Cyanea nozakii, were obtained from camera observation images, method determined. provided visual information on number their positions water column demonstrated that they more frequently located mid-upper...
ABSTRACT Peste des petits ruminants virus (PPRV) is an important pathogen that has long been a significant threat to small ruminant productivity worldwide. Iron metabolism vital the host and pathogen. However, mechanism underlying host-PPRV interactions from perspective of iron iron-mediated membrane lipid peroxidation not reported thus far. In this study, we identified novel long-noncoding RNA (lncRNA), APR, impairs PPRV infectivity by sponging miR-3955-5p, negative microRNA (miRNA)...
Escherichia coli can cause intestinal diseases in humans and livestock, destroy the barrier, exacerbate systemic inflammation, seriously threaten human health animal husbandry development. The aim of this study was to investigate whether antimicrobial peptide mastoparan X (MPX) effective against E. infection. BALB/c mice infected with by intraperitoneal injection, which represents a sepsis model. In study, MPX exhibited no toxicity IPEC-J2 cells notably suppressed levels interleukin-6...
To explore the potential intracellular mechanism of antimicrobial peptide HJH-3 in killing Salmonella , a DNA blocking test and scanning electron microscopy (SEM) were used to determine ability bind bacterial vitro .
As a promising substitute for antibiotics, increasing attention has been given to the clinical application of antimicrobial peptides (AMPs). In this study, mode action HJH-3 against Salmonella Pullorum was investigated. The structure and properties were examined in silico, minimum inhibitory concentrations (MICs) determined evaluate its spectrum. time-kill kinetics determined. hemolytic activity by measuring hemoglobin ultraviolet absorption value, cytotoxicity using CCK-8 kit. protective...
With the overuse of antibiotics, multidrug-resistant bacteria pose a significant threat to human health. Antimicrobial peptides (AMPs) are promising alternative conventional antibiotics. This study examines antimicrobial and membrane activity HJH-1, cationic peptide derived from hemoglobin α-subunit bovine erythrocytes P3. HJH-1 shows potent against different bacterial species associated with infection causes weaker hemolysis erythrocytes, at least five times minimum inhibitory concentration...
Infectious bursal disease virus (IBDV) is still a vital etiological agent in poultry farms. IBDV outbreaks occasionally occur due to the presence of very virulent, reassortment or variant strains. Vaccine immunization has played crucial roles IBD control for decades. However, survival pressure from vaccine also increases reassortments circulating viruses. In this study, an strain was isolated several broiler farms Henan Province, central part China, and named HN strain. Based on results...
The antibiotic resistance of Salmonella has become increasingly serious due to the increased use antibiotics, and antimicrobial peptides have been considered as an ideal alternative. can induce macrophage apoptosis thus further damage immune system. peptide JH-3 shown a satisfactory anti-Salmonella effect in previous research, but its mechanism action remains unknown. In this study, effects on macrophages infected with Typhimurium CVCC541 were evaluated at cellular level. results showed that...
Enterocytozoon bieneusi is an obligate intracellular microsporidian parasite with a worldwide distribution. As zoonotic pathogen, E. can infect wide range of wildlife hosts through the fecal-oral route. Although feces flying squirrels ( Trogopterus xanthipes ) are considered traditional Chinese medicine (as “faeces trogopterori”), no literature available on infection in to date. In this study, total 340 fresh squirrel fecal specimens from two captive populations were collected Pingdingshan...
The increasing rates of resistance to traditional anti-Salmonella agents have made the treatment invasive salmonellosis more problematic, which necessitates search for new antimicrobial compounds. In this study, action mode BSN-37, a novel antibacterial peptide (AMP) from bovine spleen neutrophils, was investigated against Salmonella enterica serovar Typhimurium (S. Typhimurium). Minimum inhibitory concentrations (MICs) and time-kill kinetics BSN-37 were determined. cell membrane changes S....
Abstract Background The regions in the middle of nonstructural protein 2 (nsp2) porcine reproductive and respiratory syndrome virus (PRRSV) have been shown to be nonessential for PRRSV replication, these are different various viral strains. Finding In this study, nsp2 an attenuated vaccine strain (HuN4-F112) highly pathogenic were identified based on infectious cDNA clone HuN4-F112. results demonstrated that segments [amino acids (aa) 480 667] tolerated deletions. Characterization mutants...
Two kinds of hollow silica materials, namely H‐SiS1 and H‐SiS2, were synthesized using the yeast template method Pickering emulsion polymerization method, respectively. The adsorbents to adsorb amoxicillin (AMX) from an aqueous environment. Characterization results indicated that exhibited excellent thermal stability even at temperatures above 700 °C. Several batches static adsorption experiments prepared analyze performance on AMX. Isotherm data different fitted well with Langmuir model...