A5036171469- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
Hanoi Medical University
2024
Ho Chi Minh City Open University
2022-2024
Nanyang Technological University
2021
A G-quadruplex-specific DNA endonuclease was constructed by fusing a RHAU G-quadruplex recognition domain with Fok1 cleavage domain, providing useful tool for detection of structures.
Abstract Tyrosine kinase 2 (TYK2) is a member of the JAK family nonreceptor tyrosine kinase, together with JAK1, JAK2, and JAK3. JAKs are important signaling mediators many proinflammatory cytokines represent compelling pharmacological targets for autoimmune inflammatory diseases. Pan-acting small-molecule inhibitors were approved treatment rheumatoid arthritis ulcerative colitis. However, their limited selectivity among members have led to undesirable side effects, driving search toward...
G-quadruplexes (G4s) are reported to present on the SARS-CoV-2 RNA genome and control various viral activities. Specific ligands targeting those nucleic acid structures could be investigated as promising detection methods or antiviral reagents suppress this menacing virus. Herein, we demonstrate binding between a G4 structure in of fluorescent probe created by fusing parallel-G4 specific RHAU53 cyan protein. The RHAU peptide was easily detected under fluorescence spectrometer. drawbacks...