A5001206466- Malaria Research and Control
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Kidney Stones and Urolithiasis Treatments
- Intraperitoneal and Appendiceal Malignancies
- Dialysis and Renal Disease Management
- Epilepsy research and treatment
- Analytical Methods in Pharmaceuticals
- SARS-CoV-2 and COVID-19 Research
- Neonatal Health and Biochemistry
- Systemic Lupus Erythematosus Research
- Appendicitis Diagnosis and Management
- Drug Solubulity and Delivery Systems
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Hernia repair and management
- Hops Chemistry and Applications
- Airway Management and Intubation Techniques
- Acute Kidney Injury Research
- Intestinal and Peritoneal Adhesions
- Animal Virus Infections Studies
- Hemodynamic Monitoring and Therapy
Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya
2024
Dhulikhel Hospital
2023
AstraZeneca (United States)
2017-2020
NHS Lanarkshire
2018
PharmacoGenetics (China)
2017
P. D. Hinduja Hospital and Medical Research Centre
2016
Rabindranath Tagore Medical College
2015
Government Medical College
2012
Jamia Hamdard
2009
Background. Artemisinins, which are derived from plants, subject to risk of supply interruption due climatic changes. Consequently, an effort identify a new synthetic antimalarial was initiated. A fixed-dose combination arterolane maleate (AM), trioxolane, with piperaquine phosphate (PQP), long half-life bisquinoline, evaluated in patients uncomplicated Plasmodium falciparum malaria. Methods. In this multicenter, randomized, double-blind, comparative, parallel-group trial, 1072 aged 12–65...
Arterolane (RBx 11160) maleate is a novel, rapidly acting synthetic trioxolane antimalarial compound being developed by Ranbaxy Research Laboratories (Haryana, India). It presently under phase III in combination with piperaquine phosphate. The present work reports the relationship between pharmacokinetic (PK) parameter (AUC(0-8h) on day 0/day 6) and indices of pharmacodynamic (PD) response (50% parasite clearance [PC(50)], 90% [PC(90)], time [PCT], recrudescence) from II, double-blind,...
Chloroquine has been the treatment of choice for acute vivax malaria more than 60 years. Malaria caused by Plasmodium recently shown resistance to chloroquine in some places. This study compared efficacy and safety fixed dose combination (FDC) arterolane maleate piperaquine phosphate (PQP) with uncomplicated malaria. Patients aged 13–65 years confirmed mono-infection P. along fever or previous 48 h were included. The 317 eligible patients randomly assigned receive FDC PQP (n = 159) 158) 3...
Piperaquine phosphate is an orally active bisquinolone antimalarial drug that has been used for the past 3 decades. The authors report safety, tolerability, and pharmacokinetics of piperaquine from a classical controlled phase I study. It was double-blind, randomized, parallel-group, placebo-controlled, single- multiple-dose During rising single-dose study, single ascending oral doses 500, 750, 1000, 1250, 1500 mg were administered, whereas in once-daily administered consecutive days....
Arterolane (RBx11160, OZ277) maleate is a rapidly acting synthetic trioxolane anti-malarial. This randomized, placebo controlled study was phase I to evaluate the clinical safety and tolerability as well pharmacokinetics (PKs) of arterolane including food effect. Eight single rising oral doses (25, 50, 100, 150, 200, 300, 400, 600 mg), effect under fed fasting conditions at 100 mg dose four multiple regimens 200 mg) were administered once daily for 7 days in 64 healthy young males...
The World Health Organization (WHO) recommends artemisinin combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. present study investigated efficacy and safety fixed dose (FDC) arterolane maleate 37.5 mg piperaquine phosphate (PQP) 187.5 dispersible tablets in paediatric patients aged 6 months to 12 years. Male female years who were confirmed cases P. mono-infection with fever or documented history previous 24 h included. administered FDC PQP as single...
The clinical investigation was done on 45 dogs suffering from gastroenteritis. affected showed diarrhoea, vomition, depression, anorexia and dehydration. Significant decrease in plasma glucose, albumin, potassium chloride were observed. randomly divided into three groups. In group-I (n = 15), levofloxacin given along with antiemetic, vit B-complex fluid therapy. group-II 15) group-III cefotaxime ceftriaxone used instead of levofloxacin. present that therapeutic regimen (levofloxacin) most...
Hypertrophic cardiomyopathy (HOCM) that includes thickening of one or both the ventricular walls, hypertrophy interventricular septum; systolic and diastolic dysfunction, transient hypertrophic sub-aortic stenosis is a well-recognized comorbidity in infants diabetic mothers. This cardiac complication infant mother has recently been named as pathological to avoid confusion with autosomal dominant form congenital HCM. We report neonate was diagnosed case asymmetrical septal born who had poor...
Abstract Background Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose ease administration will improve adherence compliance in children. The fixed-dose dispersible tablet arterolane maleate (AM) 37.5 mg piperaquine phosphate (PQP) 187.5 make dosing convenient Methods This multicenter (India Africa), comparative, parallel-group trial enrolled 859 patients aged 6 months 12 years Plasmodium falciparum...
Abstract AZD9833 is a potent, orally delivered, non-steroidal selective estrogen receptor degrader (SERD) that both antagonizes and degrades ERα. It currently in clinical testing for the treatment of ER+ metastatic breast cancer (SERENA-1; NCT03616587). While ER clinically validated target, sustained inhibition target via oral delivery has proven an elusive goal. Despite intensive research, no SERD options are approved. Poor pharmacokinetic (PK) properties and/or short half-life (t ½) often...
Objective: To determine the incidence and risk factors of acute renal failure (ARF) in hospitalized critically ill neonates analyze outcome all with relation to factors.Material & methods: In this prospective observational study 815 infants were enrolled. Renal profile (blood urea serum creatinine) was done after 12 h life (or at time admission for outborn babies) then every hourly. Daily 24 urine output evaluated.Results: Incidence 10.67%. Out 87 ARF 52 (60%) expired. Mortality group...
Aim: To evaluate the utility of four radiographic methods for assessing cardiomegaly and left atrial enlargement in dogs with myxomatous mitral valve disease (MMVD) Study Design: Thirty-one client owned varying severity were subjected to thoracic radiography echocardiography. Place Duration Study: Department Veterinary Surgery Radiology, DGCN College Animal Sciences, between July 2023 2024 Methodology: MMVD underwent Vertebral heart size (VHS), vertebral (VLAS), dimension (RLAD), (LA) Width...
This was an open label, balanced, randomized, three-treatment, three-sequence, three period, single-dose, crossover bioavailability study in which healthy adults (age18-45 years) were randomized to receive sustained release tablets of Voveran SR (Product R), Nac A) and Reactin B) each containing diclofenac sodium 100 mg with at least 3 days wash out between treatments. Eighteen healthy, adult, male, human subjects who met the inclusion exclusion criteria as described protocol enrolled study....
A simple, rapid, sensitive and selective assay based liquid chromatography-tandem mass spectrometric method was developed validated for quantitative analysis of meropenem in rat plasma using rolipram as internal standard. Efficient chromatographic separation analyte from matrix components achieved by Kromasil 100 C<sub>18</sub> (150×4.6 mm, 5 µm) reversed phase column with mobile consisting acetonitrile 2 mM ammonium acetate buffer (80:20, v/v) delivered isocratic mode constant flow rate 0.7...
Introduction: Hypertension is a chronic medical condition with severe consequences and it remains inadequately managed everywhere. Medication adherence critical parameter for achieving strict blood pressure control in patients undergoing antihypertensive therapy. Good medication also key factor determining the success of preventive measures cardiovascular risk reduction. So, we aimed to study among hypertensive Salyan Hospital.
 Method: A cross-sectional observational was conducted...
Background: Pneumonia is the commonest lung disease which a major cause of mortality and morbidity in young children common acute respiratory infection. The presentation varies among cases. study was done to know risk factors, clinical profile, radiological findings, short-term outcome admitted patients with pneumonia between six months sixteen years at Dhulikhel Hospital.Methods: A hospital based observational prospective cross-sectional 65 cases over period 17 Pediatrics department...