A5055476088- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Genital Health and Disease
- Autophagy in Disease and Therapy
- Dermatological and COVID-19 studies
- Protein Tyrosine Phosphatases
- Systemic Lupus Erythematosus Research
- Drug-Induced Adverse Reactions
- Peroxisome Proliferator-Activated Receptors
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Rheumatoid Arthritis Research and Therapies
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Physiological and biochemical adaptations
- Spondyloarthritis Studies and Treatments
- Otitis Media and Relapsing Polychondritis
Yunnan University of Traditional Chinese Medicine
2024-2025
Yunnan Provincial Hospital of Traditional Chinese Medicine
2024-2025
First Affiliated Hospital of Kunming Medical University
2022-2024
Yunnan University
2022-2024
Kunming Medical University
2022-2024
ABSTRACT Background Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types and SUA levels remains undetermined. Methods Bidirectional Mendelian randomization (MR) analysis based on genome‐wide association studies was used to assess relationship risk in European Asian populations. Results Forward MR showed significantly associated with lower ( p = 0.0013). The estimated effect...
Objectives Attenuated humoral response to mRNA SARS-CoV-2 vaccines has been reported in some patients with autoimmune disease, e.g., rheumatoid arthritis (RA). However, data of immune responses inactivated vaccine the RA population are still unknown. Herein, safety and immunogenicity were analyzed. Methods Seventy five 26 healthy controls (HC) respectively recruited from Yunnan Provincial Hospital Traditional Chinese Medicine community Kunming city. Neutralizing Antibody (NAb) Test ELISA kit...
To evaluate the immunogenicity of third dose inactivated SARS-CoV-2 vaccine in rheumatoid arthritis (RA) patients and explore effect RA drugs on immunogenicity. We recruited (n = 222) healthy controls (HC, n 177) who had been injected with a vaccine, their neutralizing antibody (NAb) titer levels were assessed. HC age- gender-matched, mean interval between 3rd vaccination sampling was comparable. The NAb titers significantly lower after immunization compared HC. positive rate group 90.4%,...
Abstract Objective This study aimed to explore the link between dietary vitamin C intake and hyperuricemia/gout, utilizing Mendelian randomization assess causality. Methods We analyzed cross‐sectional data from National Health Nutrition Examination Survey (2007–2018) investigate association. studies, using genetic genome‐wide association surveys, were conducted infer causality hyperuricemia/gout. The weighted logistic regression analysis instrumental variable based on inverse‐variance...
This study aimed to identify genes associated with autophagy and potential diagnostic biomarkers by comparing the gene expression profiles of synovial tissues in patients rheumatoid arthritis (RA) healthy individuals, aiming offer new insights for clinical treatment strategies. We used publicly available datasets analyze differentially expressed (DEGs) between tissue RA individuals. Then, we intersected these DEGs autophagy-related patients. further analyzed biological processes functions...
Gouty arthritis (GA) is a type of self-limiting inflammatory caused by deposition monosodium urate (MSU). This study aimed to analyze the expression variation messenger RNAs (mRNAs) in GA patients and investigated role mRNAs pathogenesis.Five with acute (AGA), 5 non-acute (NAGA), healthy controls (HC) were recruited examine differential mRNA profiles peripheral blood mononuclear cells (PBMCs) explore whether involved pathogenesis AGA. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...
Syndrome (Zheng in Mandarin Chinese) is the induction of disease attributes theory traditional Chinese medicine (TCM). This often used to explain why patients with same show different symptoms. Cold and heat represent two basic tendencies a syndrome; therefore, identification cold syndromes key diagnosis treatment rheumatoid arthritis (RA) according TCM. However, thinking model identifies reliance on clinical manifestations, which inevitably affected by subjectivity doctors. It important...