A5061191979- Mercury impact and mitigation studies
- Environmental Toxicology and Ecotoxicology
- Zebrafish Biomedical Research Applications
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Marine animal studies overview
- Bee Products Chemical Analysis
- Forensic Fingerprint Detection Methods
- Animal testing and alternatives
- Dye analysis and toxicity
- Insect Utilization and Effects
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Genetics and Reproduction
- Dyeing and Modifying Textile Fibers
- MicroRNA in disease regulation
- Marine Biology and Environmental Chemistry
- Radioactive contamination and transfer
- Marine and environmental studies
- Radioactivity and Radon Measurements
- Delphi Technique in Research
- Technology Assessment and Management
- Microplastics and Plastic Pollution
- Bioeconomy and Sustainability Development
- Sperm and Testicular Function
- Plant and animal studies
University of Aberdeen
2022-2025
Heidelberg University
2019-2024
Nuclear Decommissioning Authority
2022-2024
University of the Basque Country
2022
Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish ( Danio rerio ) embryo, OECD guideline (TG) 236, has been designed as an alternative for acute fish toxicity testing such Test (TG 203). To provide equivalent sensitivity to test, original FET was use only four morphological core endpoints: coagulation of lack somite formation, heart beat, and non-detachment tail. These endpoints were selected due (1) their association mortality, directly or indirectly, (2)...
Hazard assessment, based on new approach methods (NAM), requires the use of batteries assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all procedures required to allow test information usable integrated hazard strategic project decisions and/or regulatory purposes. The EU-ToxRisk developed a provide regulatorily valid data, and exemplified this using panel > 20 assays (with 50 endpoints),...
Filter feeders are target species for microplastic (MP) pollution, as particles can accumulate in the digestive system, disturbing feeding processes and becoming internalized tissues. MPs may also carry pathogens or pollutants present environment. This work assessed influence of polystyrene (PS) MP size concentration on accumulation depuration time role vectors metallic (Cd) organic (benzo(a)pyrene, BaP) pollutants. One-day exposure to pristine induced a concentration-dependent gland (in...
Subsea pipelines carrying well fluids from hydrocarbon fields accumulate mercury. If the (after cleaning and flushing) are abandoned in situ, their degradation may release residual mercury into environment. To justify pipeline abandonment, decommissioning plans include environmental risk assessments to determine potential of These risks informed by quality guideline values (EQGVs) governing concentrations sediment or water above which toxicity occur. However, these guidelines not consider...
To achieve net zero greenhouse gas emission by 2050 as set out the 2019 amendment to 2008 UK Climate Change Act, a major shift towards renewable energy is needed. This includes development of new methods along with improving and upscaling existing technologies. One example in bioenergy developing
This modelling study uses the ERICA Tool and Bateman's equation to derive sediment threshold values for radiation protection of marine environment relevant NORM-contaminated products (radium-contaminated scales, 210Pb films 210Po films) found in subsea oil gas infrastructure. Threshold are calculated as activity concentration products' head chain radionuclide (i.e., 226Ra + 228Ra, 210Pb, or 210Po) that will increase dose rates sediments by 10 μGy/h most exposed organism at a given release...
In the aim to determine neurotoxicity, new methods are being validated, including tests and test batteries comprising in vitro vivo approaches. Alternative models such as zebrafish (Danio rerio) embryo have received increasing attention, with minor modifications of fish toxicity (FET; OECD TG 236) a tool assess behavioral endpoints related neurotoxicity during early developmental stages. The spontaneous tail movement assay, also known coiling assesses development random into complex patterns...
The North Sea is an ecologically rich habitat for marine wildlife which has also been impacted by industrial developments and anthropogenic emissions of contaminants such as mercury. Marine mammals are particularly susceptible to mercury exposure, due their trophic position, long lifespan, dependence on (increasingly contaminated) aquatic prey species. To mitigate impact, can detoxify methylmercury binding it selenium-containing biomolecules, creating insoluble selenide granules. Here,...
Abstract Early life conditions can have long-lasting fitness effects on organisms. In insects, crowding during larval stages impose a significant constraint adult phenotypes due to increased intraspecific competition for resources, which modulate males’ success in pre- and post-mating adulthood. Evidence male seminal fluid allocation exists but is limited small subset of well-known proteins (Sfps), often overlooks the interactions between female phenotypes. We currently lack comprehensive...
The need for reliable, sensitive (developmental) neurotoxicity testing of chemicals has steadily increased. Given the limited capacities routine according to accepted regulatory guidelines, there is potential risk human health and environment. Most toxicity studies are based on mammalian test systems, which have been questioned low sensitivity, relevance humans, animal welfare considerations. This increased alternative models, one zebrafish (Danio rerio) embryo. study assessed selected...
Quantifying impacts on marine ecosystems remains pivotal in estimating risks associated with offshore industry practices. Cuttings piles, formed during drilling operations, are commonly abandoned situ, and left to attenuate the seabed. In present work, presence lability of mercury samples obtained from drill cuttings piles two decommissioned North Sea oil platforms (bp Miller bp West Hutton) surrounding sediment were investigated. Maximum concentrations total measured at 0.23 0.37 μg/g dry...
Abstract The fish embryo acute toxicity (FET) test with the zebrafish ( Danio rerio ) according to OECD TG 236 was originally developed as an alternative method for testing to, e.g., 203. Given versatility of protocol, however, FET has found application beyond a common tool in environmental hazard and risk assessment. Whereas standard guideline is restricted four core endpoints (coagulation well lack somite formation, heartbeat, tail detachment) simple, rapid assessment toxicity, further can...
Mercury is a naturally occurring heavy metal that has also been associated with anthropogenic sources such as cement production or hydrocarbon extraction. contaminant of concern it can have significant negative impact on organismal health when ingested. In aquatic environments, bioaccumulates up the foodweb, where then potential to human health. With offshore platforms in North Sea nearing decommissioning, they must be assessed source for environmental release mercury. International treaties...
The Sea of Azov, an inland shelf sea bounding Ukraine and Russia, experiences the effects ongoing legacy pollution. One main contaminants concern is heavy metal mercury (Hg), which emitted from regional coal industry, former Hg refineries, historic use mercury-containing pesticides. aquatic biome acts both as a major sink source in this cycle, thus meriting examination its environmental fate. This study collated existing data for SoA adjacent region to estimate current influxes cycling...
The global oceans are facing a plethora of pressures, leading to cross-national impacts on marine ecosystems, wildlife, and resource users. Interdisciplinarity is integrating knowledge methods from different disciplines generate comprehensive output. Due the trans-boundary nature habitats stressors, interdisciplinary research forms basis addressing pressing matters in ocean health conservation. To this end, Marine Environment Resources (MER) master programme was developed at beginning...
Prolonged exposure to food dyes, even for those considered safe consumption, are known have toxic effects. However, we lack a proper understanding of the underlying compounds that responsible observed toxicity. Here, tested effects three common commercially available natural dyes (red, green, blue), and their main ingredients (turmeric spirulina), on Drosophila melanogaster oviposition, larval development, foraging behaviour. Larval development egg-to-adult survival was significantly...
Abstract Amino acids are the building blocks of proteins that perform essential physiological functions. Theory suggests proteome composition, amino acid frequencies across all in a genome, is associated with an organism’s optimal growth temperature, offering insights into species’ temperature limits. However, this hypothesis, based on prokaryotes, has not been tested complex multicellular eukaryotes where many strictly acquired through diet. Here, we analysed proteomes orthologous and...
Abstract Prolonged exposure to food dyes, even for those considered safe consumption, are known have toxic effects. However, we lack a proper understanding of the underlying compounds that responsible observed toxicity. In this study, tested physiological effects three common commercially available natural dyes (red, green, blue), and their main ingredients (turmeric spirulina), on Drosophila melanogaster oviposition, larval development, foraging behaviour. Larval development egg-to-adult...
With increasing annual chemical development and production, safety testing demands requirements have also increased. In addition to traditional animal testing, quantitative structure-activity relationship (QSAR) modelling can be used predict the biological effect of a structure, based on analysis characteristics structure features. Whilst suitable for e.g., pharmaceuticals, other compounds more challenging model. The naturally occurring heavy metal mercury speciates in environment, with some...
Quantifying anthropogenic impacts on marine ecosystems remains pivotal in estimating risks associated with current and future offshore industry practices. The North Sea has a long history of oil gas production adheres to some the strictest environmental regulations globally. Cuttings piles, formed during initial drilling operations, are commonly abandoned situ left attenuate seabed. While adverse impact contained hydrocarbons surrounding sediment ecosystem been assessed detail, less is known...
Abstract The chemical behavior of mercury (Hg) and its interactions with naturally occurring ligands shape environmental fate impact. neurotoxic properties Hg are widely known studied both in vitro vivo . However, there continues to be limited information on the influence chelation large organic toxicity marine macro-organisms. This work examined effect complexed various types dissolved matter (DOM) mortality hatching success Artemia sp. nauplii under varying media conditions. results...