A5100347537- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Bone fractures and treatments
- Atrial Fibrillation Management and Outcomes
- Moyamoya disease diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Tryptophan and brain disorders
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Cerebral Venous Sinus Thrombosis
- Knee injuries and reconstruction techniques
- Neurological Disease Mechanisms and Treatments
- Orthopaedic implants and arthroplasty
- Neuroblastoma Research and Treatments
- Inflammation biomarkers and pathways
- Intracranial Aneurysms: Treatment and Complications
- Vascular Procedures and Complications
- Bioinformatics and Genomic Networks
Taipei Veterans General Hospital
2018-2024
National Yang Ming Chiao Tung University
2022-2024
National Taiwan University Hospital
2024
Sun Yat-sen University
2021-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2024
Kaohsiung Veterans General Hospital
2013-2024
Tungs' Taichung MetroHarbor Hospital
2023-2024
Kang-Ning Junior College of Medical Care and Management
2023-2024
Nationwide Children's Hospital
2016-2024
Zhongnan Hospital of Wuhan University
2023
Objective ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of intestine and endothelial blood–brain barrier. Intestinal ABCB1 actively transports drugs from cell membrane prevents them entering blood stream whereas barrier central nervous system. In this study, we tested whether genetic polymorphisms within gene are associated with severity depression effectiveness antidepressant, escitalopram (S-CIT), in treating...
Young stroke incidence has increased worldwide with lifestyle changes. Etiology and risk factors for both ischemic hemorrhagic in young Asians remain underexplored.We retrospectively reviewed consecutive acute patients aged 16-45 years admitted to the Taipei Veterans General Hospital between 2009 2019 analyze etiologic subtypes, factors, serial modified Rankin Scale scores 1 year compare age groups of 16-30 31-45 years.Among 670 Taiwanese (mean at onset 37.5 ± 7.0 years; male 65.1%), there...
Surgical managements are recommended for unstable distal clavicle fractures because of a high incidence nonunion. A variety methods have been previously reported, but there is no current consensus regarding which method the most suitable.Between December 2004 and August 2010, we treated 68 patients with Neer type IIB using single coracoclavicular suture fixation Mersilene tape (M group) or clavicular hook plate (H group). Sixty-eight were followed at least 24 months (mean, 37.9 months). We...
<h3>Objectives</h3> Hypertensive crisis is categorised into hypertensive urgency and emergency. The present work aimed to determine the effect of different gradings blood pressure (BP) ratios in predicting severity paediatric crisis. <h3>Methods</h3> This was a retrospective case series, based emergency departments Changhua Christian Hospital Tzu-Chi General Hospital, Taiwan. From 1995 2010, correlation between hypertension (HTN) difference elevated systolic BP 99th percentile plus 5 mm Hg...
Here, we compared the clinical and radiographic outcomes between coracoclavicular (CC) fixation with Mersilene tape hook plate for acute unstable acromioclavicular (AC) joint dislocation treatment. We enrolled 49 patients AC who, January 2010 2014, underwent surgery single CC suture (M group, 25 cases) or clavicle (H 24 cases). In M H groups, average age was 43.7 (range 18–72) 42.0 17–84) years, male to female ratio of each group 15:20 19:5, injured side left right 12:13 11:13, respectively....
Colorectal cancer (CRC) is currently the third leading cause of cancer-related deaths worldwide, and 5-fluorouracil (5-FU)-based chemotherapies serve as important adjuvant therapies before after surgery for CRC. However, efficacy CRC chemotherapy limited by chemoresistance, therefore discovery novel markers to indicate chemosensitivity essential. Nerve growth factor receptor (NGFR), a cell surface receptor, involved in death survival. Our previous study indicated that NGFR acts tumor...
Introduction: Hematuria is a worrisome symptom in children and sometimes associated with urinary tract infections (UTIs). This study aimed to identify useful clinical factors that can predict UTIs hematuria patients without pyuria the pediatric emergency department (ED). Methods: We retrospectively recruited from ED. Clinical symptoms, urine biochemistry microscopic examination results, blood laboratory tests were analyzed predictors of UTIs. Patients divided into verbal group (age ≥ 2...
Introduction The prevalence of cardiovascular disease (CVD) and CVD-related deaths in patients with schizophrenia is high. An elevated risk CVD has been associated low heart rate variability (HRV). There increasing evidence that fatty acid-binding protein (FABP)3 FABP4 play roles the development progression CVD. This study aimed to explore association circulating FABP3/FABP4 levels HRV chronic schizophrenia. Methods We included 265 consecutive who attended a management program. used an...
Abstract Background The Mild Behavioral Impairment Checklist (MBI‐C) was developed to assess neuropsychiatric symptoms (NPS) and identify mild behavioral impairment (MBI). This study validated the Taiwanese version of MBI‐C examined its association health‐related quality life (HR‐QoL). Methods We recruited 242 older individuals without dementia (129 amnestic cognitive impairment, 113 cognitively normal). Their family completed MBI‐C, Neuropsychiatric Inventory Questionnaire (NPI‐Q),...
Left atrial appendage closure (LAAC) is a novel treatment for stroke prevention in high-risk patients with non-valvular fibrillation (NVAF). However, the long-term outcomes after LAAC Chinese NVAF are still lacking.This was single-center, bidirectional, nonrandomized registered study. Patients who underwent implantation from May 2014 to April 2021 large center were enrolled. The primary endpoint combined all-cause death and stroke.From 2021, total of 673 overall successful rate 97.62% (657...
Whole exome sequencing (WES) has been used to detect rare causative variants in neurological diseases. However, the efficacy of WES genetic diagnosis clinically heterogeneous familial stroke remains inconclusive. We prospectively searched for disease-causing unrelated probands with defined by candidate gene/hotspot screening and/or WES, depending on subtypes and neuroimaging features at a referral center. The clinical significance each variant was determined according American College...
Fever may serve as the primary indicator of underlying infection in children admitted to pediatric emergency department (PED), especially high-risk young infants. This study aimed identify early clinical factors that could help predict bacteremia febrile infants.The included infants under 90 days age who were PED due fever. Patients divided into two groups based on presence or absence and further three groups: (1) less than 30 days, (2) 59 (3) 60 days. Several laboratory variables analyzed,...
Abstract Background Use of combinations long-acting β 2 agonists/long-acting muscarinic antagonists (LABA/LAMA) in patients with chronic obstructive pulmonary disease (COPD) is increasing. Nevertheless, existing evidence on cardiovascular risk associated LABA/LAMA versus another dual combination, LABA/inhaled corticosteroids (ICS), was limited and discrepant. Aim The present cohort study aimed to examine comparative safety LABA/ICS a target trial emulation framework, focusing fixed-dose...
Traumatic brain injury is the most common cause of morbidity and mortality in children. However, it still challengeable to early predict outcome individual patients with severe head injuries. Glasgow scale widely used scoring system evaluating neurological for patients. Moreover, likely underestimate not always readily applicable It an important issue develop a practical, reliable valid instrument children forwarding research.
Cardiogenic shock (CS) is uncommon in patients suffering from acute myocardial infarction (AMI). Long-term outcome and adverse predictors for outcomes AMI with CS receiving percutaneous coronary interventions (PCI) are unclear. A total of 482 who received PCI were collected, including 53 429 non-CS. Predictors recurrent MI, cardiovascular (CV) mortality, all-cause repeated-PCI analyzed. The group had a lower central systolic pressure diastolic (both P < 0.001). hypertension history less...
Previous studies have reported that large fracture fragment with displacement might cause nonunion of femoral shaft fractures. We therefore intended to delineate significant risk factors for developing a predisposed by major fragment. analyzed 61 patients who were operated on using interlocking nails fractures from 2009 2018. classified modified Radiographic Union Scale Tibia scores less than 11 or needing reoperations 1 year postoperatively as nonunion. thereafter measured parameters the...
Background: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of Alzheimer’s disease (AD), and decreased peripheral levels this protein are associated with an increased risk developing disease. This study focuses on whether serum BDNF could be used as a predictor AD progression. Methods: In longitudinal observational study, we recruited cognition normal participants (N = 98) 442) from Clinic at Taipei Veterans General Hospital. We conducted mini-mental...
Abstract Essential hypertension involves complex cardiovascular regulation. The autonomic nervous system function fluctuates throughout the sleep–wake cycle and changes with advancing age. However, precise role of in development during aging remains unclear. In this study, we characterized different age groups essential hypertension. This study included 97 men (53 44 without hypertension) aged 30–79 years. They were stratified by into young (< 40 years), middle-aged (40–59 older (60–79...