A5068333193- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Mycobacterium research and diagnosis
- Genetics, Bioinformatics, and Biomedical Research
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Sex and Gender in Healthcare
- Ethics in Clinical Research
- Viral Infections and Outbreaks Research
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
- Diversity and Career in Medicine
- Immune Response and Inflammation
National Institute of Diabetes and Digestive and Kidney Diseases
2024
National Institutes of Health
2022-2024
Emory University
2014-2017
Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th1) IL-17 (Th17) important for protecting against (TB), but the mechanisms by which DCs generate during Mtb infection not well defined. We previously reported CD40 expression on restricts Th1 Th17 responses. now demonstrate CD40-dependent costimulation is required to Mtb. CD40-deficient were...
Mycobacterium tuberculosis (Mtb) employs multiple strategies to evade host immune responses and persist within macrophages. We have previously shown that the cell envelope-associated Mtb serine hydrolase, Hip1, prevents robust macrophage activation dampens pro-inflammatory responses, allowing delay detection accelerate disease progression. now provide key mechanistic insights into molecular biochemical basis of Hip1 function. establish is a protease with activity against protein peptide...
Mycobacterium tuberculosis successfully subverts the host immune response to promote disease progression. In addition its known intracellular niche in macrophages, M. interferes with functions of dendritic cells (DCs), which are primary antigen-presenting system. We previously showed that dampens proinflammatory responses and impairs DC through cell envelope-associated serine protease Hip1. Here we present data showing GroEL2, a substrate Hip1, modulates functions. The full-length GroEL2...
Abstract Background Equitable representation of members from historically marginalized groups is important in clinical trials, which inform standards care. The goal this study was to characterize the demographics and proportional subgroup reporting participants enrolled randomized controlled trials (RCTs) antibacterials used treat Staphylococcus aureus infections. Methods We examined registrational strategy published 2000 2021 determine sex, race, ethnicity participants. Participant...
Abstract Dendritic cells (DCs) play a key role in the generation of CD4 T cell responses to pathogens. Mycobacterium tuberculosis (Mtb) harbors immune evasion mechanisms that impair DC and prevent optimal immunity. The vaccine strain bovis Bacille Calmette-Guérin (BCG) shares many proteins utilized by Mtb, but these elicited BCG is poorly understood. We previously reported Mtb serine protease, Hip1, promotes sub-optimal during infection. Here, we tested hypothesis Hip1 modulates functions...