A5027070660- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Long-Term Effects of COVID-19
- Nanoparticle-Based Drug Delivery
- Gastric Cancer Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Kawasaki Disease and Coronary Complications
- Ultrasound and Hyperthermia Applications
- Colorectal Cancer Treatments and Studies
Brigham and Women's Hospital
2022
Harvard University
2020-2022
Boston Children's Hospital
2021-2022
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked exuberant inflammation, how triggers inflammation not understood. Monocytes macrophages are sentinel immune cells the blood tissue, respectively, sense invasive infection form inflammasomes activate caspase-1 gasdermin D (GSDMD) pores, leading inflammatory (pyroptosis) processing release IL-1 family cytokines, potent mediators....
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in some patients. Although severe COVID-19 disease is linked exuberant inflammation, how triggers inflammation not understood. Monocytes are sentinel blood cells sense invasive infection form inflammasomes activate caspase-1 gasdermin D (GSDMD) pores, leading inflammatory (pyroptosis) processing release of IL-1 family cytokines, potent mediators. Here we show ~10% monocytes patients dying infected...
Colorectal cancer, common in both men and women, occurs when tumors form the linings of colon. Common treatments colorectal cancer include surgery, chemotherapy, radiation therapy; however, many often damage healthy tissues cells, inducing severe side effects. Conventional chemotherapeutic agents such as doxorubicin (Dox) can be potentially used for treatment cancer; they suffer from limited targeting lack selectivity. Here, we report that complexed to hyaluronic acid (HA) (HA-Dox) exhibits...
Abstract Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single agents. Polymer–drug conjugates can be used to deliver combinations with a ratiometric dosing. However, behaviors effectiveness this system have never been well investigated in GBM models. Here, we report flexible hyaluronic acid (HA) camptothecin (CPT) doxorubicin (DOX) delivered into brain using focused ultrasound (FUS). In vitro...