A5043595250- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Adenosine and Purinergic Signaling
- Phosphodiesterase function and regulation
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Virus-based gene therapy research
- Neuroendocrine regulation and behavior
Georgia Institute of Technology
2023-2024
National Institute of Mental Health
2023
National Institute of Mental Health
2022-2023
University of Rochester Medical Center
2023
University of Pennsylvania
2023
National Institutes of Health
2022
University of Maryland, College Park
2022
Abstract Background Dopaminergic circuits play important roles in the motivational control of behavior and dysfunction dopaminergic have been implicated several psychiatric disorders, such as schizophrenia depression. While these disorders exhibit different incidence rates men women, potential sex differences underlying neural are not well-understood. Previous anatomical tracing studies mammalian species revealed a prominent circuit projection connecting midbrain ventral tegmental area (VTA)...
Accumulation of the ribonucleoside, adenosine (ADO), triggers a cAMP response element binding protein (CREB)-mediated signaling pathway to suppress function immune cells in tumors. Here, we describe collection CREB-activated promoters that allow for strong and tunable ADO-induced gene expression human cells. By optimizing number CREB transcription factor sites altering core promoter region CREB-based hybrid promoters, created synthetic constructs drive higher levels than strong, endogenous...
Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive remain unresponsive and novel paradigms investigating the circuit substrates underlying deficits are critically needed. The frontal cortex its dopaminergic input from midbrain functions undergo maturational changes during adolescence. Here, we used mice carrying mutations Arc or Disc1 to model mesofrontal dopamine deficiencies...
Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive remain unresponsive and novel paradigms investigating the circuit substrates underlying deficits are critically needed. The frontal cortex its dopaminergic input from midbrain functions undergo maturational changes during adolescence. Here, we used mice carrying mutations Arc or Disc1 to model mesofrontal dopamine deficiencies...
Adenosine is a potent immunosuppressive metabolite that accumulates in the extracellular space within solid tumors and inhibits antitumor function of native immune cells responses as well chimeric antigen receptor (CAR) T cell therapies.Here, we show engineered human can degrade adenosine through secretion deaminase (ADA) enzymesa possible therapeutic enhancement for CAR cells.We first determine high-activity ADA1 isoform naturally intracellularly restricted showed addition canonical or...
Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying deficits are critically needed. The frontal cortex its dopaminergic input from midbrain functions undergo maturational changes during adolescence. Here, we used mice carrying mutations Arc...
Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying deficits are critically needed. The frontal cortex its dopaminergic input from midbrain functions undergo maturational changes during adolescence. Here, we used mice carrying mutations
Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying deficits are critically needed. The frontal cortex its dopaminergic input from midbrain functions undergo maturational changes during adolescence. Here, we used mice carrying mutations Arc...