A5063690968- Plant-based Medicinal Research
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Poisoning and overdose treatments
- Pharmaceutical studies and practices
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Drug-Induced Hepatotoxicity and Protection
- Analytical Methods in Pharmaceuticals
- Pharmaceutical Practices and Patient Outcomes
- Pharmacology and Obesity Treatment
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Polyamine Metabolism and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Neurotoxicity Research
- Amino Acid Enzymes and Metabolism
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Cannabis and Cannabinoid Research
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Diet and metabolism studies
- Neuroscience of respiration and sleep
University of Manitoba
2011-2022
Columbus Oncology and Hematology Associates
2014-2021
University of Florida
2013-2020
National Institutes of Health Clinical Center
2017
Reckitt Benckiser (United States)
2016-2017
Princeton University
2016
Case Western Reserve University
2013
Impact
2013
Quantitative BioSciences
2013
Therapeutics Clinical Research
1979-2011
A survey of drug‐related admissions patients aged 50 years and older was conducted at the Health Sciences Centre, Winnipeg to determine interrelationship risk factors, isolate effect age. All nonelective medical were prospectively assessed role drug therapy as a contributory factor. Of 863 eligible admissions, 162 exhibited least one adverse patient event (DRAPE) time hospitalization. This accounted for 19% (23% 718 that involved prescription drugs). Although reactions responsible many...
To characterize further the pharmacokinetics of theophylline in premature infants, its concentraion blood was measured by high-pressure liquid chromatography after intravenous infusion given to six apneic newborns three 15 days age. Theophylline's apparent volume distribution 0.690 +/- 0.095 liters per kilogram (mean S.E.), a value similar that children, but half-life (30.2 6.5 hours) nine times longer. Blood clearance rate (17.6 2.3 ml hour) lower than plasma (100 young children. At total...
OBJECTIVE: To compare medication adherence calculated from four different data sources including a pill count and self-report obtained during home history, as well calculations based on refill frequency derived provincial prescription claims database (manual electronic). DESIGN: Baseline was collected part of prospective, randomized, controlled study. Mean results the were compared using repeated-measures ANOVA followed by Tukey's multiple range test. SETTING: A pharmacy consultation service...
To determine the role of liver dysfunction in theophylline toxicity, we administered single intravenous doses drug to nine patients with cirrhosis and observed its disposition over a period 24 48 hours. As compared 19 normal subjects, these had prolonged plasma half-life (mean, 25.6 vs. 6.7 hours) decreased clearance 0.042 0.062 liter[kg-1]hr-1). Volumes distribution cirrhotic (central-compartment volume 0.330, steady-state 0.785 liter per kilogram) did not substantially differ from (0.246...
Prescription claims data have been used to estimate refill medication adherence through calculations of cumulative acquisition (CMA) and gap (CMG) values. Few studies assessed the validity these calculated rates.We sought assess CMA CMG from Manitoba prescription database (DPIN) against pill count adherence, targeting overall medications angiotensin converting enzyme inhibitors (ACEIs).Using a survey convenience sample subjects recruited community pharmacies, who were eligible for study (ie,...
Pharmacodynamic investigations with antimicrobials define the relationship between infecting organism and achievable drug concentrations clinical outcome.To examine this for meropenem in a population of patients who are at high risk infection-related morbidity mortality.The study was retrospective analysis multicenter, randomized, blinded trial. A population-based predictive model created using data from adults febrile neutropenia nonparametric modeling program, NPEM. Patient age, body...
The kinetic disposition of morphine was compared in 13 young and 7 older healthy subjects after a single intravenous dose 10 mg/70 kg morphine. apparent volume distribution at steady state elderly only half that subjects. This difference derived from reductions both central peripheral compartment volumes the beta elimination phase for more rapid, but its plasma clearance reduced Calculation concentration these indicated drug this space higher 1.5 hr dosing.
Nine patients with acute cardiogenic pulmonary edema were given theophylline intravenously, and its disposition was observed over the next 24 hr. Compared to that in 19 normal subjects, these had prolonged plasma half-lifes (mean, 22.9 from 6.7 hr) decreased clearances of 0.041 0.062 L [kg-1] hr-1). The intersubject variation parameters 20-fold 4-fold subjects. Since peak concentrations attained apparent volumes distribution not different two groups, a suitable initial dose can be...
<b>Background:</b> Whether the enteric absorption of neuraminidase inhibitor oseltamivir is impaired in critically ill patients unknown. We documented pharmacokinetic profile admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza. <b>Methods:</b> included 41 18 years age and older influenza who were for ventilatory support nine ICUs three cities Canada Spain. Using tandem mass spectrometry, we assessed plasma levels free base its active metabolite...
The objective of this research is to use metabolomic techniques discover and validate plasma metabolite biomarkers for the diagnosis early-stage non-small cell lung cancer (NSCLC). study included samples from 156 patients with biopsy-confirmed NSCLC along age gender-matched 60 healthy controls. A fully quantitative targeted mass spectrometry (MS) analysis (targeting 138 metabolites) was performed on all samples. sample set split into a discovery validation set. Metabolite concentration data,...
ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains HIV-1. Prior to discovery receptors as HIV coreceptors, was used in phase I/II clinical trials evaluate its therapeutic potential against HIV-1, making first anticoreceptor be tested humans Patients highest dose groups achieved levels above effective concentration drug for nearly entire 1-month treatment period. well tolerated by 39 40 asymptomatic HIV-infected patients, despite critical role...
Overdose with modified-release pharmaceuticals is an increasing phenomenon. This study examines whole-bowel irrigation as a potential decontamination strategy after overdose enteric-coated acetylsalicylic acid and compares it administration of activated charcoal in sorbitol, which currently the recommended intervention. A three-phase randomized crossover protocol was used 10 adult volunteers. Each volunteer ingested nine 325 mg doses on three occasions, at least 1 week between each period....
To test the hypothesis that antituberculous drug disposition is altered in patients with AIDS, we studied steady-state pharmacokinetics of isoniazid (300 mg/d), rifampin (600 and pyrazinamide (1,500 mg/d) 29 adults (14 infected human immunodeficiency virus [HIV] 15 non-HIV-infected patients) tuberculosis Nairobi, Kenya. Intestinal integrity was assessed xylose. Neither HIV infection nor diarrhea accounted for interpatient variability area-under-the-plasma concentration vs. time curve (AUC),...
We present a specific, sensitive high-pressure liquid-chromatographic assay for theophylline in plasma. Only 0.5 ml of plasma is required each determination, and the lower limit detection by this method 0.1 mg/liter. Other xanthines their metabolites do not interfere. This suitable use studying pharmacokinetics drug infants children, from whom only small volumes blood are available.
Long‐term hemodialysis frequently requires vascular access through central venous catheters (CVCs). Infection related to these is a significant complication. The use of an antibiotic‐heparin lock could decrease the risks associated with infected permanent catheters. As initial step in developing lock, we investigated vitro stability combinations CVCs. Initially, cefazolin, vancomycin, ceftazidime, ciprofloxacin 10 mg/ml each, and gentamicin 5 were incubated separately glass test tubes dark...
We studied the short-term effect of oral doses quinine and quinidine on renal clearance amantadine in healthy young (age range, 27 to 39 years) older 60 72 adults both genders a three-limbed randomized crossover study. Renal (13.2 ± 5.8 L/hr) was significantly inhibited by (9.7 4.8 (8.9 4.0 only male subjects not associated with age. The chiral selectivity for over confirmed extended suggestion age- gender-associated changes ratio these two diastereomeric drugs. These data support continued...
We asked whether the anesthetic requirement (MAC) of fetal lambs is lower than that pregnant ewes. In five ewes anesthetized with a subarachnoid block, foot was withdrawn through hysterotomy. The ewe then breathed 1.5% halothane and clamp applied to at 2-min intervals. concomitantly obtained arterial blood from previously implanted catheters. When movement in response clamping ceased, discontinued stimulus sampling continued until fetus began move. Anesthesia again resumed stopped. deepened...