A5064751989- Alzheimer's disease research and treatments
- Inflammatory Myopathies and Dermatomyositis
- Skin Diseases and Diabetes
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Heterotopic Ossification and Related Conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cellular transport and secretion
- Genetic Associations and Epidemiology
- Celiac Disease Research and Management
- Metabolomics and Mass Spectrometry Studies
- Lysosomal Storage Disorders Research
Washington University in St. Louis
2024-2025
Istanbul University-Cerrahpaşa
2020
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers been recruited to participate cognitive, neuropsychologic, imaging, fluid biomarkers, genomic multi-omic studies. Tissue longitudinal data collected foster, facilitate, support on dementia aging....
Amyloid-PET imaging tracks the accumulation of amyloid beta (Aβ) deposits in brain. Amyloid plaques may begin 10 to 20 years before individual experiences clinical symptoms associated with Alzheimer's diseases (ad). Recent large-scale genome-wide association studies reported common risk factors brain amyloidosis, suggesting that this endophenotype is driven by genetic variants. However, these loci pinpoint large genomic regions and functional variants remain be identified. To identify new...
Abstract Background Amyloid PET imaging is a promising biomarker to track the accumulation of parenchymal amyloid beta (Aβ) deposits in brain. Recent large‐scale genome‐wide association studies (GWAS) reported common risk factors associated with amyloidosis, suggesting that this endophenotype driven by genetic variants. We hypothesized genes multiple variants deleterious effect are Aβ accumulation. To address issue, we performed whole‐genome sequencing (WGS) on large cohort individuals...
Abstract There is growing evidence suggesting that the lysosome or dysfunction associated with Alzheimer’s disease (AD). Pathway analysis of post mortem brain-derived proteomic data from AD patients shows lysosomal system perturbed relative to similarly aged unaffected controls. However, it unclear if these changes contributed pathogenesis are a response disease. Consistent hypothesis contributes pathogenesis, whole genome sequencing indicate heterozygous pathogenic mutations and predicted...
Background: Idiopathic inflammatory myopathies (IIM), mainly dermatomyositis (DM) and polymyositis (PM) are the diseases of musculoskeletal system most commonly affecting proximal muscles limbs. In addition to muscle inflammation, these conditions multisystemic, presenting with a variety complaints. Objectives: As IIMs infrequent, single-center experience quantitative data describing in-depth information on nature disease treatment seems useful. Methods: This retrospective study was...
Background: Idiopathic inflammatory myopathies (IIM) are essentially treated aiming improvement of muscle function and extra muscular disease manifestations. The backbone the treatment is corticosteroids enhancing survival patient quality life. lack consensus on target-specific immunosuppressive highlights need for further studies evaluating alternative methods. Rituximab potentially a glucocorticoid-sparing agent which was reviewed in multiple with small sample sizes due to rarity disease....