A5006608774- Cancer Genomics and Diagnostics
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Molecular Biology Techniques and Applications
- Parasite Biology and Host Interactions
- Mosquito-borne diseases and control
- Science, Research, and Medicine
- Viral Infections and Vectors
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Genetics and Neurodevelopmental Disorders
- Viral Infections and Outbreaks Research
- Child Development and Digital Technology
- Family Support in Illness
- Insect symbiosis and bacterial influences
- Shoulder Injury and Treatment
- Single-cell and spatial transcriptomics
- HIV-related health complications and treatments
- Open Education and E-Learning
- Parasitic Infections and Diagnostics
- Parasitic Diseases Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Bone fractures and treatments
- Cancer survivorship and care
Genomics (United Kingdom)
2023-2024
Centro de Información y Desarrollo de la Mujer
2022
Universidad Panamericana
2018
Universidad Complutense de Madrid
2017
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2017
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2017
Universidad de la Cordillera
2016
Hospital Universitario Ramón y Cajal
2015
Abstract Purpose: Detection of circulating tumor DNA (ctDNA) in patients who have completed treatment for early-stage breast cancer is associated with a high risk relapse, yet the optimal assay ctDNA detection unknown. Experimental Design: The cTRAK-TN clinical trial prospectively used tumor-informed digital PCR (dPCR) assays molecular residual disease (MRD) triple-negative cancer. We compared dPCR personalized multimutation sequencing 141 from cTRAK-TN. Results: MRD was first detected by...
To investigate human babesiosis in the Bolivian Chaco, 2013 we tested blood samples from 271 healthy persons living 2 rural communities this region. Microscopy and PCR indicated that 3.3% of were positive for Babesia microti parasites (US lineage); seroprevalence was 45.7%. Appropriate screening should mitigate risk transfusion-associated babesiosis.
Autism Spectrum Disorders (ASD) comprise a group of heterogeneous and complex neurodevelopmental disorders. Genetic environmental factors contribute to ASD etiology. DNA methylation is particularly relevant for due its mediating role in the interaction between genotype environment has been implicated pathophysiology. The lack diversity studies individuals remarkable. Since genetic are likely vary across populations, study underrepresented populations necessary understand molecular...
Introduction: In 2013 a coproparasitological survey was carried out in two rural communities of the Bolivian Chaco to determine prevalence intestinal parasitic infections (IPIs) and investigate on possible infection drivers through questionnaire interview. Methodology: Faecal samples were examined by microscopy. Samples positive for Entamoeba histolytica complex Blastocystis molecularly identify species/subtypes involved. Results: The overall rate 86%, identical both mostly due protozoa....
A hybridization-based point-of-care (POC) assay for HIV-1 drug resistance would be useful in low- and middle-income countries (LMICs) where testing is not routinely available. The major obstacle developing such an the extreme genetic variability of HIV-1. We analyzed 27,203 reverse transcriptase (RT) sequences from Stanford HIV Drug Resistance Database originating six LMIC regions. characterized a 27-nucleotide window surrounding clinically important mutations (DRMs) at positions 65, 103,...
The expanded use of long-term antiretroviral treatments in infected children may exacerbate the problem drug resistance mutations selection, which can compromise treatment efficiency.We describe temporal trends HIV and HIV-1 variants during 23 years (1993 to March 2016) Madrid cohort HIV-infected adolescents.We selected patients with at least one available pol sequence/genotypic profile, establishing different groups according sampling year first data. We determined prevalence transmitted or...
The most-used protease-inhibitor in children is Lopinavir-ritonavir (LPV/r), which provides durable suppression of viral load and increases CD4+T-counts. This study describes the virological outcome HIV-1-infected paediatric population exposed to LPV/r during 15 years Spain.Patients from Madrid Cohort HIV-1-infected-children adolescents as different line therapy 2000-2014 were selected. baseline epidemiological-clinical features, suppression, changes CD4+T-CD8+T cell counts drug...
To determine the seroprevalence of antibodies against dengue virus (DENV) and West Nile (WNV) in human population Bolivian Chaco, we tested 256 inhabitants two rural communities. The seroprevalence, confirmed by plaque reduction neutralization test, was 7.8% 2.7% for DENV WNV, respectively.
<div>AbstractPurpose:<p>Detection of circulating tumor DNA (ctDNA) in patients who have completed treatment for early-stage breast cancer is associated with a high risk relapse, yet the optimal assay ctDNA detection unknown.</p>Experimental Design:<p>The cTRAK-TN clinical trial prospectively used tumor-informed digital PCR (dPCR) assays molecular residual disease (MRD) triple-negative cancer. We compared dPCR personalized multimutation sequencing 141 from...
Abstract Background: Circulating tumor DNA (ctDNA) to track early clones and identify the point of origin in relapsed disease, could provide novel insights into impact heterogeneity on development MRD relapse TNBC. Methods: c-TRAK TN recruited 161 patients (pts) with TNBC prospective ctDNA surveillance after curative therapy. Two distinct tissue samples were provided, a subset provided biopsy. Tissue was whole exome sequenced (WES) plasma underwent error-corrected WES. Clonal evolution...
<p>Correlation between the tumor fraction percentage as reported by mean Variant Allele Frequency (mean VAF) or estimated (eVAF) for RaDaR ctDNA assay.</p>
<div>AbstractPurpose:<p>Detection of circulating tumor DNA (ctDNA) in patients who have completed treatment for early-stage breast cancer is associated with a high risk relapse, yet the optimal assay ctDNA detection unknown.</p>Experimental Design:<p>The cTRAK-TN clinical trial prospectively used tumor-informed digital PCR (dPCR) assays molecular residual disease (MRD) triple-negative cancer. We compared dPCR personalized multimutation sequencing 141 from...
<p>Comparison of median lead time from ctDNA detection to relapse between dPCR and RaDaR assays using paired data in all individuals with (n=40).</p>