A5062683030- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Chemokine receptors and signaling
- Reproductive System and Pregnancy
- Cancer Risks and Factors
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- Thyroid Disorders and Treatments
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Intraperitoneal and Appendiceal Malignancies
- Hepatitis C virus research
- Natural product bioactivities and synthesis
- Uterine Myomas and Treatments
- Hematological disorders and diagnostics
- interferon and immune responses
Ladies College
2025
Osaka University
2014-2023
Okayama University
1987-2023
Osaka International Cancer Institute
2023
The Jikei University Hospital
2018
The University of Tokyo
1997-2014
Abstract Granulocyte-colony stimulating factor (G-CSF) producing malignant tumor has been reported to occur in various organs and associated with poor clinical outcome. The aim of this study is investigate the significance G-CSF expression chemosensitivity uterine cervical cancer. data recurrent or advanced cancer patients who were treated platinum-based chemotherapy analyzed. Clinical samples, cell lines a mouse model employed examine mechanisms responsible for development chemoresistance...
Tumor-related leukocytosis (TRL) is occasionally found in patients with nonhematopoietic malignancies. We investigated the clinical implication of TRL and individualized treatment for TRL-positive cervical cancer, as well underlying biological mechanism. Clinical data from 258 cancer treated definitive radiotherapy were analyzed to investigate association between outcome. samples, cell lines, a mouse model used examine mechanisms responsible focusing on role tumor-derived granulocyte...
To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous (AC/ASC) among locally advanced cancer that were treated definitive radiotherapy. The baseline characteristics outcome data who radiotherapy between November 1993 February 2014 collected retrospectively reviewed. A Cox proportional hazards regression model was used to investigate prognostic significance AC/ASC histology. cervix exhibited significantly shorter overall (OS)...
// Hiromasa Kuroda 1, * , Seiji Mabuchi Eriko Yokoi Naoko Komura 1 Katsumi Kozasa Yuri Matsumoto Mahiru Kawano Ryoko Takahashi Tomoyuki Sasano Kotaro Shimura Michiko Kodama Kae Hashimoto Kenjiro Sawada Eiichi Morii 2 and Tadashi Kimura Department of Obstetrics Gynecology, Osaka University Graduate School Medicine, Osaka, Japan Pathology, These authors contributed equally to this work Correspondence to: Mabuchi, email: smabuchi@gyne.med.osaka-u.ac.jp Keywords: MDSC; CSC; prostaglandin E2;...
Purpose: The aim of this study was to investigate the metastatic potential uterine cervical and endometrial cancer displaying tumor-related leukocytosis (TRL).Experimental Design: Clinical data on (N = 732) 900) were collected, TRL-positive evaluated in univariate multivariate analyses. Tumor blood samples obtained from patients with cancer, cell lines, a mouse model used examine mechanisms underlying highly nature focusing tumor-derived G-CSF myeloid-derived suppressor (MDSC)-mediated...
Systemic inflammatory responses including thrombocytosis, leukocytosis, or neutrophilia have gained attention as prognostic indicators in patients with various solid malignancies.current study, we aimed to investigate the clinical implications and underlying biological mechanism of systemic response endometrial cancer. Clinical data from 900 cancer were analyzed association between pretreatment treatment outcome. samples, cell lines, a mouse model used examine mechanisms responsible for...
Abstract The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate impact pretreatment tumor-related leukocytosis (TRL) on diagnostic performance 18F-FDG-PET/CT in detecting pelvic paraaortic lymph node metastasis. We demonstrate that TRL...
Abstract The aim of this study was to determine the role AKT as a therapeutic target in ovarian clear cell carcinoma (CCC), an aggressive, chemoresistant histologic subtype cancer. activation assessed by immunohistochemistry (IHC) using human tissue microarrays primary cancers, composed both CCC and serous adenocarcinoma (SAC). growth-inhibitory effect AKT-specific targeting small-molecule inhibitor, perifosine, examined lines vitro vivo. Finally, activity perifosine CCC-derived tumors that...
Objective The objective of this study was to evaluate the antitumor effects lurbinectedin as a single agent or in combination with existing anticancer agents for clear cell carcinoma (CCC) ovary, which is regarded an aggressive, chemoresistant, histological subtype. Methods Using human ovarian CCC lines, lurbinectedin, SN-38, doxorubicin, cisplatin, and paclitaxel were assessed using MTS assay. Then, therapies involving 1 other 4 evaluated isobologram analysis examine whether these...
To investigate the clinical implications of 17β-estradiol (E2) in estrogen receptor α (ERα)-negative female cancer progression as well underlying biological mechanisms.Clinical data from 306 locally-advanced cervical (stage IIB-IVA) patients were analyzed order to relationships between age, serum E2 levels, and treatment outcomes. Clinical samples, ERα-negative breast cell lines, mouse xenograft models cancers employed elucidate mechanisms responsible for E2- pregnancy-mediated cancers, with...
Follitropin delta is a novel recombinant follicle-stimulating hormone preparation used for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The dosage determined using an original algorithm designed to achieve target retrieval of 8-14 oocytes based on body weight and anti-Müllerian (AMH) levels. However, unexpected poor responses, characterized by low oocyte numbers, occasionally occur patients with high AMH levels who are otherwise expected respond well. This study...
// Katsumi Kozasa 1 , Seiji Mabuchi Naoko Komura Eriko Yokoi Kuroda Hiromasa Tomoyuki Sasano Mahiru Kawano Yuri Matsumoto Eiji Kobayashi and Tadashi Kimura Departments of Obstetrics Gynecology, Osaka University Graduate School Medicine, Suita, Osaka, Japan Correspondence to: Mabuchi, email: smabuchi@gyne.med.osaka-u.ac.jp Keywords: cervical cancer, thrombocytosis, survival, platelet count, platelet-lymphocyte ratio Received: April 11, 2017 Accepted: July 12, Published: 25, ABSTRACT...
Presence of high-risk factor in cervical cancer is known to be associated with decreased survival outcomes. However, the significance multiple factors early-stage related outcomes, recurrence patterns, and treatment implications not well elucidated.A retrospective study was conducted for surgically treated patients (stage IA2-IIB, n=540). Surgical-pathological risk were examined tumors expressing ≥1 (nodal metastasis, parametrial involvement, or positive surgical margin) eligible analysis...
Aim: To evaluate the ability of PM01183 to eliminate myeloid-derived suppressor cells (MDSCs). Materials & methods: The effect on MDSCs, NK and CD8+ T was examined in vitro vivo. mechanism by which depletes MDSCs also investigated. Results: reduced number inducing apoptosis attenuated MDSC-mediated suppression inhibiting arginase-1 production, whereas no significant or noted. inhibitory MDSC mediated attenuation STAT3 phosphorylation. greater than those existing anticancer agents....
Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC not yet well understood. In this study, we analyzed SHH OSCC.We examined expression pattern and signal proteins clinically resected samples by immunohistochemistry. We also evaluated function using inhibitor cyclopamine vivo vitro proliferation, migration angiogenesis analyses.We found that was highly expressed human tongue OSCC, whereas patched (PTCH1),...
The aim of this study was to investigate the prognostic significance a pretreatment thrombocytosis and its association with neutrophilia in patients surgically treated endometrial cancer.The baseline characteristics outcome data 508 cancer between January 2000 December 2010 were collected retrospectively reviewed. separated into 4 groups according their platelet counts neutrophil counts, progression-free overall survival rates compared. A Cox proportional hazards regression model used...
The aim of this study was to identify prognostic factors and establish a model for predicting life expectancy in International Federation Gynecology Obstetrics stage IVB cervical cancer patients.The baseline characteristics outcome data patients with between May 1994 October 2014 were collected retrospectively reviewed. A Cox proportional hazards regression used independent predictors survival patients.A total 107 included our database. median overall (OS) period 16 months. Multivariate...