A5001391773- Collembola Taxonomy and Ecology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemiptera Insect Studies
- Parasitic infections in humans and animals
- Insect and Arachnid Ecology and Behavior
- Vagus Nerve Stimulation Research
- Parasitic Infections and Diagnostics
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Invertebrate Taxonomy and Ecology
- Immune Response and Inflammation
- Piperaceae Chemical and Biological Studies
- Brucella: diagnosis, epidemiology, treatment
- Amoebic Infections and Treatments
- Marine and coastal plant biology
- Study of Mite Species
- Plant and soil sciences
- Intensive Care Unit Cognitive Disorders
- Medicinal Plants and Neuroprotection
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Cocoa and Sweet Potato Agronomy
- Advanced Drug Delivery Systems
- Plant and animal studies
- Toxoplasma gondii Research Studies
Universidad Nacional Autónoma de México
2009-2024
Secretaria de Salud
2020-2024
Universidad Autónoma del Estado de Morelos
2024
Agence des Aires Marines Protégées
2024
Philipps University of Marburg
2021
Universidad de Guadalajara
2008-2015
Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious non-infectious neuropathologies, its amelioration usually improves patient outcome. Peripheral inflammation may promote NI through microglia astrocytes activation, an increased expression inflammatory mediators vascular permeability that lead to neurodegeneration. Several anti-inflammatory strategies have been proposed control peripheral inflammation. Among them, electrical stimulation vagus nerve (VNS)...
Genetic and sexual factors influence the prevalence pathogenesis of many inflammatory disorders. In this study their relevance on peripheral central status induced by a injection lipopolysaccharide (LPS) was evaluated. BALB/c CD-1 male female mice were intraperitoneally injected with LPS. Spleens brains collected 2 72 hours later to levels IL-6, TNF-α IL-1β. Percentage microglia astrocytes determined in cortex hippocampus. Locomotor activity registered before during after LPS-treatment. Two...
Neuroinflammation is the hallmark of several infectious and neurodegenerative diseases. Synthetic glucocorticoids (GCs) are first-line immunosuppressive drugs used for controlling neuroinflammation. A delayed diffusion GCs molecules high systemic doses required brain-specific targeting lead to severe undesirable effects, particularly when lifelong treatment required. Therefore, there an urgent need improving this current therapeutic approach. The intranasal (i.n.) route being employed...
Taeniids exhibit a great adaptive plasticity, which facilitates their establishment, growth, and reproduction in hostile inflammatory microenvironment. Transforming Growth Factor-β (TGFβ), highly pleiotropic cytokine, plays critical role vertebrate morphogenesis, cell differentiation, reproduction, immune suppression. TGFβ is secreted by host cells sites lodging parasites. The of the outcome T. solium crassiceps cysticercosis herein explored. Homologues family receptors (TsRI TsRII) several...
Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine has been developed previously as an aid to interrupt transmission shown be effective. The results of present study support effectiveness under endemic field conditions. However, given time-frame vaccination trial, no changes local levels were detectable before after using sentinel pigs. Thus,...
Relapsing-remitting multiple sclerosis, the most common form, is characterized by acute neuroinflammatory episodes. In addition to continuous disease-modifying therapy, these relapses require treatment prevent lesion accumulation and progression of disability. Intravenous methylprednisolone (1-2 g for 3-5 days) standard relapses. However, this invasive, requires hospitalization, leads substantial systemic exposure glucocorticoids, can only reach modest concentrations in central nervous...
A retrospective study of our 14-yr records on experimental Taenia crassiceps (ORF(fast) line) cysticercosis (n = 1,198) shows that in 16 17 different mice strains, female are more frequently infected and carry larger individual parasite loads than males. However, sexual differences significantly varies between strains relation to their genetic backgrounds (BALB > C57Bl OTHERS C3H). The coefficient variation all is smaller males, an indication males' potent, but erratically effective,...
By end December of 2021, COVID-19 has infected around 276 million individuals and caused over 5 deaths worldwide. Infection results in dysregulated systemic inflammation, multi-organ dysfunction, critical illness. Cells the central nervous system are also affected, triggering an uncontrolled neuroinflammatory response. Low doses glucocorticoids, administered orally or intravenously, reduce mortality among moderate severe patients. However, low by these routes do not reach therapeutic levels...
Neuroinflammation (NI) is an important physiologic process which promotes the tissue repair and homeostatic maintenance in central nervous system after different types of insults. However, when it exacerbated sustained time, NI plays a critical role pathogenesis neurologic diseases. The high systemic doses required for brain-specific targeting lead to severe undesirable effects. intranasal (IN) route has been proposed as alternative drug administration better control. Herein, brain...
Introducción. En el 2021, la Secretaría de Salud México y Organización Panamericana lanzaron una iniciativa para interrumpir transmisión vectorial intradomiciliaria Trypanosoma cruzi, fundamentada en prevalencia enfermedad Chagas población infantil. El estado mexicano Veracruz fue pionero esta iniciativa.Objetivo. Estimar seroprevalencia infección por T. cruzi menores 15 años localidades rurales Veracruz, México.Materiales métodos. Se identificaron ocho prioritarias serología basal del...
Las vacunas constituyen, sin duda, una de las herramientas más valiosas en la historia medicina, pues han permitido prevenir gran cantidad infecciones virales y bacterianas, tanto para el ser humano como algunas especies animales. De acuerdo con OMS, actualmente permiten evitar dos a tres millones muertes cada año población humana. En este artículo difusión se presenta un breve recorrido por vacunas, así detalles su formulación términos moléculas que generalmente desarrollan, naturaleza...
The disease caused by Taenia solium is progressively being recognized as a growing global threat for public human health and pig husbandry that requires the development of effective control measures. A central participant in taeniasis/cysticercosis transmission network carrier adult tapeworm because its great potential spreading infection. Herein, evidence presented primary infection golden hamsters with orally administered T. cysticerci improved host's resistance against secondary Likewise,...
Dry pods of cacao are an important habitat exploit by different ant species to establish their nest, and conditions, diverse organisms associated them also occupied such nests. We studied the composition assemblage accompanying arthropods in fall hanging from experimental areas Ilhéus, Bahia, Brazil. A total 34 dry fruits were reviewed. The six ants, with Neoponera villosa as commonest, while fallen eight nested, Camponotus cingulatus occupying most 50% them. 42 taxa founded ants 37 (15...
Experimental murine cysticercosis caused by Taenia crassiceps has proved to be a useful model with which test the efficacy of new vaccine candidates and delivery systems against pig cysticercosis. A high level protection was previously observed intramuscular or intradermal DNA immunization use sequence recombinant KETc7 antigen cloned in pcDNA3 (pTc-sp7). To determine effect differential expression vaccination, pGEM 11Zf( ) under control tissue-specific regulatory promoter...