A5071492956- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Diabetic Foot Ulcer Assessment and Management
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
Université de Montréal
2022-2024
Lebanese University
2022
Abstract Worldwide prevalence of cervical cancer decreased significantly with the use human papilloma virus (HPV)‐targeted prophylactic vaccines. However, these multivalent antiviral vaccines are inert against established tumors, which leave patients surgical ablative options possibly resulting in long‐term reproductive complications and morbidity. In an attempt to bypass this unmet medical need, we designed a new E7 protein‐based vaccine formulation using Accum™, technology platform promote...
Abstract Background Mesenchymal stromal cells (MSCs) have been extensively used in the clinic due to their exquisite tissue repair capacity. However, they also hold promise field of cellular vaccination as can behave conditional antigen presenting response interferon (IFN)-gamma treatment under a specific regimen. This suggests that immune function MSCs be pharmacologically modulated. Given capacity agonist pyrimido-indole derivative UM171a trigger expression various presentation-related...
Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting (APCs) using either genetic engineering or pharmacological means. Given the capacity of UM171a trigger APC-like function in MSCs, and recent finding this drug may modulate epigenome by inhibiting lysine-specific demethylase 1 (LSD1), we explored whether direct inhibition LSD1 could instill functions...
Mesenchymal stromal cells (MSCs) are largely known for their immune-suppressive capacity, hence, common use in the control of unwanted inflammation. However, novel concepts related to biology, combined with urgent need identify MSC subpopulations enhanced suppressive properties, drive search isolation protocols optimized clinical applications. We show, this study, that MSCs expressing high CD146 levels exhibit altered surface expression profiles CD44 and secrete elevated interleukin (IL)-6,...
Mesenchymal stromal cells (MSCs) have been modified via genetic or pharmacological engineering into potent antigen-presenting cells-like capable of priming responding CD8 T cells. In this study, our screening a variant library Accum molecule revealed (A1) eliciting antigen cross-presentation properties in MSCs. A1-reprogrammed MSCs (ARM) exhibited improved soluble uptake and processing. Our comprehensive analysis, encompassing assays molecular profiling, among other cellular investigations,...