A5082053391- Electron Spin Resonance Studies
- Radiation Effects and Dosimetry
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Lanthanide and Transition Metal Complexes
- Radiation Detection and Scintillator Technologies
- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Analytical Chemistry and Sensors
- Nanoplatforms for cancer theranostics
- Nonmelanoma Skin Cancer Studies
- Rocket and propulsion systems research
- Carcinogens and Genotoxicity Assessment
- Microbial Inactivation Methods
- Luminescence Properties of Advanced Materials
- Atomic and Subatomic Physics Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cutaneous Melanoma Detection and Management
- MRI in cancer diagnosis
Dartmouth College
2015-2024
Marshall Space Flight Center
2021-2024
Dartmouth Cancer Center
2022-2024
Dartmouth Psychiatric Research Center
2016-2024
Dartmouth Health
2024
Dartmouth–Hitchcock Medical Center
2011-2023
Walter and Eliza Hall Institute of Medical Research
2015-2021
The University of Melbourne
2008-2021
Cotton (United States)
2019-2020
USC Norris Comprehensive Cancer Center
2019-2020
Abstract This work presents a methodology for obtaining quantitative oxygen concentration images in the tumor‐bearing legs of living C3H mice. The method uses high‐resolution electron paramagnetic resonance imaging (EPRI). Enabling aspects include use injectable, narrow, single‐line triaryl methyl spin probes and an accurate model overmodulated spectra. Both these increase signal‐to‐noise ratio (SNR), resulting high resolution space (1 mm) 3 concentrations (∼3 torr). Thresholding at 15%...
Abstract Objective. Existing ultra-high dose rate (UHDR) electron sources lack independent dosimeters and a calibrated control system for accurate delivery. In this study, we aim to develop custom single-pulse monitoring real-time dose-based FLASH enabled clinical linear accelerator (Linac). Approach. A commercially available point scintillator detector was coupled gated integrating amplifier controller feedback loop. The programmed integrate each radiation pulse stop the beam when...
Recognition is growing regarding the possibility that terrorism or large-scale accidents could result in potential radiation exposure of hundreds thousands people and present guidelines for evaluation after such an event are seriously deficient. Therefore, there a great urgent need after-the-fact biodosimetric methods to estimate dose. To accomplish this goal, dose estimates must be at individual level, timely, accurate, plausibly obtained disasters. This paper evaluates current biodosimetry...
Abstract Background While careful planning and pre‐treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way attain true delivered dose. Several countries outside US require IVD for quality assurance. However, elsewhere, manual labor time considerations of traditional dosimeters may be preventing frequent use clinic. Purpose This study expands upon previous research...
A rigorous statistical analysis of the retrospective estimation radiation dose received using time to emesis and its uncertainty is provided based on 108 observations associated with accidents significant exposures ionizing in period 1956-2001. The standard error, confidence interval, specificity sensitivity, Receiver Operating Characteristic (ROC) curve are used characterize prediction. relative error prediction data about 200%. Consequently, if D assessment, 95% interval approximately...
With possibilities for radiation terrorism and intensified concerns about nuclear accidents since the recent Fukushima Daiichi event, potential exposure of large numbers individuals to that could lead acute clinical effects has become a major concern. For medical community cope with such an event avoid overwhelming care system, it is essential identify not only who have received clinically significant exposures need intervention but also those do treatment. The ability electron paramagnetic...
Purpose: A method was developed utilizing Cherenkov imaging for rapid and thorough determination of the two gantry angles that produce most uniform treatment plane during dual‐field total skin electron beam therapy (TSET). Methods: implemented to gather 2D measurements relative surface dose from 6 MeV beams on a white polyethylene sheet. An intensified charge‐coupled device camera time‐gated Linac used emission at sixty‐two different (1° increments, 239.5° 300.5°). Following modified...
Objectives: The goal of this study was to determine what extent mechanical stability affects vascular repair during fracture healing. Methods: Stabilized and nonstabilized tibia fractures were created in adult mice. Fracture tissues collected at multiple time points early Vasculature fractured limbs visualized by immunohistochemistry with an anti-PECAM-1 antibody on tissue sections then quantified stereology. Oxygen tension, endothelial growth factor expression, lactate accumulation the site...
Purpose: The ability to estimate individual exposures radiation following a large attack or incident has been identified as necessity for rational and effective emergency medical response. In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel developed meet this need.Materials methods: A novel transportable EPR spectrometer, facilitate dosimetry in an response setting, was used measure upper incisors model system, unirradiated subjects, patients who had received total...