A5103094327- Protein Degradation and Inhibitors
- Pancreatic function and diabetes
- Multiple Myeloma Research and Treatments
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Stress Responses and Cortisol
- Muscle Physiology and Disorders
- Chronic Lymphocytic Leukemia Research
- Biosimilars and Bioanalytical Methods
- Simulation-Based Education in Healthcare
- Surgical Simulation and Training
- Biotechnology and Related Fields
- Diabetes Management and Research
- Innovations in Medical Education
- GDF15 and Related Biomarkers
- Natural Antidiabetic Agents Studies
- Tryptophan and brain disorders
- Pharmaceutical Economics and Policy
- Neuropeptides and Animal Physiology
- Viral Infectious Diseases and Gene Expression in Insects
- Treatment of Major Depression
Moscow State University of Medicine and Dentistry
2023-2024
Ministry of Health of the Russian Federation
2024
The aim of the work was to conduct an analysis current state and trends in approval drugs, as well some aspects methodology for their development based on biological molecules registration. Materials methods. material taken from abstract databases PubMed, Google Scholar e-library.ru. search carried out using publications period 2008 2023, keywords were follows: “biologicals”, “new drug approval”, “drug authorization”, development”, “biosimilar”, taking into account various spellings....
Procurement of medicines reflects the demand and frequency prescribing certain drugs, which makes it possible to assess quality medical care compliance with standards. The Russian pharmaceutical market is dynamically developing expanding, therefore, commercial sector drug circulation a significant part should be studied along public procurement. Given number patients diagnosed diabetes mellitus (DM) in our country, we considered appropriate interesting analyze structure volume turnover...
2021 marks the 100th anniversary of discovery insulin, an event that forever changed lives people with diabetes mellitus. At present patients around world experience miracle insulin therapy every day. A disease used to kill children and teenagers in 2 years 1920 has become a can be controlled possibility lead long productive life. Over past century, great Banting, Best Collip saved millions lives. This review is devoted history development its further improvement: from moment days. Various...
Modern approaches to the treatment of type 2 diabetes mellitus (T2DM) are aimed not only at glycemic control, but also reducing cardiovascular risks. The increasing prevalence disease and need for effective options highlight importance glucagon-like peptide-1 (GLP-1) receptor agonists in pharmacotherapy structure. aim work was review literature regarding physiology GLP-1 therapeutic potential development trends its agonists. Materials methods. search materials carried out using abstract...
The article presents a review of literary sources dedicated to the physiological role and functions certain proteins TGFβ superfamily, specifically GDF11 GDF8, as well their place in pathogenesis several diseases whose risk increases with age. Possible therapeutic applications these are described. It is shown that described ambiguous. previously unrecognized regulator bone remodeling, prevents myocardial hypertrophy, improves condition animals experimental diabetes or neurodegeneration....
Depression is a leading cause of disability and reduced work capacity worldwide. The monoamine theory the pathogenesis depression has remained dominant for many decades, however, drugs developed on its basis have limited efficacy. Exploring alternative mechanisms underlying this pathology could illuminate new avenues pharmacological intervention. Targeting glutamatergic pathways in CNS, particularly through modulation NMDA AMPA receptors, demonstrates promising results. This review presents...