A5015657184- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Tea Polyphenols and Effects
- Vitamin D Research Studies
- Tannin, Tannase and Anticancer Activities
- Microbial Metabolites in Food Biotechnology
- Nutritional Studies and Diet
- Edible Oils Quality and Analysis
- Cancer, Lipids, and Metabolism
- Agriculture Sustainability and Environmental Impact
- Gut microbiota and health
- Consumer Attitudes and Food Labeling
- Diet and metabolism studies
- Seaweed-derived Bioactive Compounds
- Phytoestrogen effects and research
- Ginkgo biloba and Cashew Applications
- Nutrition and Health in Aging
- Pomegranate: compositions and health benefits
- Glutathione Transferases and Polymorphisms
- Pain Management and Placebo Effect
- Food Science and Nutritional Studies
- Folate and B Vitamins Research
- Dietary Effects on Health
- Fermentation and Sensory Analysis
- Cholesterol and Lipid Metabolism
University of Ulster
2016-2025
Food for Health Ireland
2007-2024
Boston University
2021
National Migraine Centre
2017-2018
International Islamic University Malaysia
2016
Clostridium difficile virulence is driven primarily by the processes of toxinogenesis and sporulation, however many in vitro experimental systems for studying C. physiology have arguably limited relevance to human colonic environment. We therefore created a more physiologically-relevant model milieu study gut pathogen biology, incorporating faecal water (FW) into growth media assessing physiological effects this on strain 630. identified novel set difficile-derived metabolites culture...
Abstract Brown seaweeds such as Ascophyllum nodosum are a rich source of phlorotannins (oligomers and polymers phloroglucinol units), class polyphenols that unique to Phaeophyceae. At present, there is no information on the bioavailability seaweed limited evidence their bioactivity in vivo . Consequently, we investigated gastrointestinal modifications vitro from A. effect inflammatory markers healthy participants. In , some phlorotannin oligomers were identified after digestion colonic...
The traditional Mediterranean diet is thought to represent a healthy lifestyle; especially given the incidence of several cancers including colorectal cancer lower in countries compared Northern Europe. Olive oil, central component diet, believed beneficially affect numerous biological processes. We used phenols extracted from virgin olive oil on series vitro systems that model important stages colon carcinogenesis. effect extract DNA damage induced by hydrogen peroxide was measured HT29...
Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation membrane by proteolytic enzymes migration cells through the modified matrix. In present study, we investigated effect phenolics extracted (OVP) its main constituents: hydroxytyrosol (3,4-dihydroxyphenylethanol),...
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity. After consumption, however, phenolic compounds subject digestive conditions within gastrointestinal tract that alter structures potentially function. However, majority not efficiently absorbed small intestine substantial portion pass into colon. We characterized...
Abstract The composition of polyphenols in ileal fluid samples obtained from an ileostomy subject after lingonberry intake was compared with extracts simulated vitro digestion (IVDL) and subsequent faecal fermentation (IVFL). HPLC‐PDA‐MS/MS analysis confirmed similar patterns (poly)phenolic metabolism the vivo digestion, reduced recovery anthocyanins a pattern for proanthocyanidins observed both methods digestion. On other hand, IVFL sample contained none original components but enriched...
Unlike other classes of polyphenols, there is a lack knowledge regarding brown seaweed phlorotannins and their bioactivity. We investigated the impact in vitro gastrointestinal digestion colonic fermentation on bioactivity phlorotannin extract from Ascophyllum nodosum its high molecular weight (HMW) low (LMW) fractions.
Studies on broccoli (Brassica oleracea var. italica) indicate beneficial effects against a range of chronic diseases, commonly attributed to their bioactive phytochemicals. Sulforaphane, the form glucoraphanin, is formed by action indigenous enzyme myrosinase. This study explored role that digestion and cooking practices play in bioactivity bioavailability, especially rarely considered dose delivered colon.The antimicrobial activity sulforaphane extracts from raw, cooked plus mustard seeds...
Abstract Vegetable consumption is associated with a reduced risk of colorectal cancer, which the second most common cancer after lung/breast within Europe. Some putative protective phytochemicals are found in higher amounts young sprouts than mature plants. The effect an extract mixed cruciferous and legume on DNA damage induced by H2O2 was measured HT29 cells using single cell microgelelectrophoresis (comet). Significant antigenotoxic (P ≤ 0.05) observed when were pre-incubated (100 200...
Abstract Abstract: Although it is known to be a rich source of the putative anti-cancer chemicals isothiocyanates, watercress has not been extensively studied for its cancer preventing properties. The aim this study was investigate potential chemoprotective effects crude extract toward three important stages in carcinogenic process, namely initiation, proliferation, and metastasis (invasion) using established vitro models. HT29 cells were used protective on DNA damage cell cycle. genotoxic...
The phenolic compositions of fecal water samples from ten free-living human subjects without marked dietary restrictions were monitored before and after intake raspberry puree (200 g/day, 4 days) using gas chromatography−mass spectrometry. No single component was increased in all intake, but a majority had significant elevations phenylacetic acid (7/10), 4-hydroxyphenylacetic (6/10), 3-hydroxyphenylacetic (5/10), 3-phenylpropionic 3-(4-hydroxyphenyl)propionic acid. levels 3,4-dihydroxbenzoic...
The soybean-derived protease inhibitor, Bowman-Birk inhibitor (BBI), is currently showing great promise as a novel cancer chemopreventive agent. In contrast to the wealth of research conducted on this compound, anticancer effects inhibitors isolated from other leguminous sources have received limited attention. current study, 7 concentrates (PICs) were various (including soybean) and characterized. PICs proliferation breast prostate cells investigated in vitro. Chickpea PIC significantly...
The (poly)phenols in ileal fluid after ingestion of raspberries were analyzed by targeted and nontargeted LC-MS(n) approaches. Targeted approaches identified major anthocyanin ellagitannin components at varying recoveries with considerable interindividual variation. Nontargeted analysis using an orbitrap mass spectrometer gave exact MS data which sifted a software program to select peaks that changed significantly supplementation. This method confirmed the recovery but also novel...