A5026431896- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Neural dynamics and brain function
- Mental Health Research Topics
- Menstrual Health and Disorders
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Child Abuse and Trauma
- Atomic and Subatomic Physics Research
- Stress Responses and Cortisol
- Muscle activation and electromyography studies
- Psychological Treatments and Assessments
- Neuroendocrine regulation and behavior
- Parkinson's Disease Mechanisms and Treatments
- Posttraumatic Stress Disorder Research
- Health and Wellbeing Research
- Biofield Effects and Biophysics
- Heart Rate Variability and Autonomic Control
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Advanced Technologies in Various Fields
- Blind Source Separation Techniques
- Advanced Neuroimaging Techniques and Applications
Harvard University
2023-2024
McLean Hospital
2023-2024
Hadassah Medical Center
2016-2024
Sage Therapeutics (United States)
2023
UNSW Sydney
2023
Io Therapeutics (United States)
2023
Neurocrine Biosciences (United States)
2023
Sunovion (United States)
2023
Otsuka (United States)
2023
Emory University
2023
Depression, anxiety and apathy are distinct neuropsychiatric symptoms that highly overlap in Parkinson's disease (PD). It remains unknown whether each symptom is uniquely associated with a functional network dysfunction. Here, we examined individual differences predict connectivity patterns PD patients while controlling for all other motor function. Resting-state MRI were acquired from 27 29 healthy controls. Widespread reduced was identified explained by either the or symptoms. Depression...
Adverse childhood experiences (ACEs) have been acknowledged as risk factors for increased mental health complications in adulthood, specifically increasing susceptibility to developing psychopathology upon exposure trauma. Yet, little is known regarding the impact of mild ACEs on highly functioning population. In this study forty participants were selected from a group 366 military parachute trainees using self-report "childhood trauma questionnaire," and classified into two groups 20 each,...
Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations a battery neuropsychological tests, to understand differences directed connectivity between young older subjects. Using novel multivariate analysis method on resting-state functional MRI data from fifty thirty-one healthy subjects, we calculated intra- inter-DMN 4-nodes pathways. For old subject group, partial pathways with: psychomotor speed working...
Abstract We describe an analysis method that characterizes the correlation between coupled time-series functions by their frequencies and phases. It provides a unified framework for simultaneous assessment of frequency latency time-series. The is demonstrated on resting-state functional MRI data 34 healthy subjects. Interactions fMRI are represented cross-correlation (with time-lag) functions. A general linear model used to obtain phase-differences original define symmetric, antisymmetric...
Network analysis is increasingly advancing the field of neuroimaging. Neural networks are generally constructed from pairwise interactions with an assumption linear relations between them. Here, a high-order statistical framework to calculate directed functional connectivity among multiple regions, using wavelet and spectral coherence has been presented. The mathematical expression for 4 regions was derived used characterize quartet as linear, combined (nonlinear), or disconnected network....
A multivariate measure of directed functional connectivity is used with resting-state fMRI data 40 healthy subjects to identify pathways signal progression in the human visual system. The method utilizes 4-nodes networks mutual interacted BOLD signals obtains their temporal hierarchy and connectivity. Patterns were defined at frequency windows by appealing a based upon phase differences, significance was assessed permutation testing. Assuming consistent relationship between neuronal...
Patients with Parkinson's disease (PD) experience motor and non-motor symptoms, suggesting alterations of the and/or limbic system or more probably their communications. We hypothesized that communication between insula (part system) sensorimotor cortex in PD is altered hemispheric asymmetric. Furthermore, this asymmetry relates to specifically, apathy-related unique PD. To test these hypotheses, we used a novel multivariate time-frequency analysis method applied resting-state functional...
Abstract The conceptualization of emotional states as patterns interactions between large-scale brain networks has recently gained support. Yet, few studies have directly examined the brain’s network structure during experiences. Here, we investigated functional organization experiences sadness, amusement, and neutral elicited by movies, in addition to a resting-state. We tested effects experienced emotion on individual variability connectome. Next, for each state, defined community...
Studies in the sensorimotor system of older versus young individuals have shown alterations functional connectivity and organization. Our objective was to explore implications these differences terms local organizations, identify processes that correlate with neuropsychological parameters.Using a novel multivariate analysis method on resting-state MRI data obtained from 50 31 healthy individuals, we identified directed 4-node pathways within examined their correlations assessments.In were...
Dopamine depletion in the axons of Parkinson's disease (PD) patients precedes cell bodies thus proposing that macroscopic connectivity can be used to understand mechanism. A novel multivariate functional analysis, based on high order coherence among four fMRI BOLD signals was applied resting-state data controls and PD (OFF ON medication states) unidirectional multiple-region pathways sensorimotor system were identified. Pathways classified as "preserved" (unaffected by disease), "damaged"...
Abstract Perceived control is strongly related to mental health and well-being. Specifically, lack of perceived has been associated with learned helplessness stress-related disorders, such as depression anxiety. However, it unknown whether brain activation its protective effect against stress can predict changes in quality life. To address this gap, we examined the neural underpinning controllability healthy females (N = 40) performing Value Control task an functional magnetic resonance...
Abstract Background Childhood sexual abuse (CSA) and emotional maltreatment are salient risk factors for the development of major depressive disorder (MDD) in women. However, type- timing-specific effects experienced during adolescence on future symptomatology women with CSA have not been explored. The goal this study was to fill gap. Methods In total, 203 (ages 20–32) current symptoms (MDD/CSA), remitted (rMDD/CSA), without (MDD/no CSA) were recruited from community completed self-report...
Abnormalities in the functional connectivity of large-scale brain networks, including default mode network (DMN), salience (SN), fronto-parietal (FPN), and limbic network, have been implicated repetitive negative thinking (RNT) – a construct characterized by intrusive thoughts. However, potential abnormalities for predicting RNT daily-life remains largely underexplored. In this study, we filled gap leveraging data-driven brain-based graph-theoretical predictive modeling (GPM) to sample 54...