A5023555167- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Aquatic Ecosystems and Biodiversity
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Fish Biology and Ecology Studies
- Curcumin's Biomedical Applications
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Medical Imaging and Analysis
- Edible Oils Quality and Analysis
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Ginseng Biological Effects and Applications
- Bee Products Chemical Analysis
- Diabetic Foot Ulcer Assessment and Management
- Environmental and Biological Research in Conflict Zones
- Pesticide Exposure and Toxicity
Damanhour University
2016-2024
Delta University for Science and Technology
2022
Tanta University
2022
King Khalid University
2020
This study investigated if kaempferol could attenuate the oxidative, inflammatory, and fibrotic damage of left ventricles (LVs) in streptozotocin (STZ)-diabetic rats by modulating silent mating type information regulation 2 homolog 1 (SIRT1) signaling. Adult male were divided into 5 groups (n = 12/each) as control, control + kaempferol, STZ-induced diabetes mellitus (STZ-DM), STZ-DM EX-527, a sirtuin inhibitor. Administration to diabetic significantly preserved systolic diastolic functions...
This study evaluated if salidroside (SAL) alleviates high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) by downregulating miR-21. Rats (
This study investigated whether the mechanism underlying neurotoxic effects of cadmium chloride (CdCl 2 ) in rats involves p 66 Shc. comprised an initial vivo experiment followed by vitro experiment. For experiment, male were orally administered saline (vehicle) or CdCl (0.05 mg/kg) for 30 days. Thereafter, spatial and retention memory tested their hippocampi used biochemical molecular analyses. control Shc-deficient hippocampal cells treated with (25 µM) presence absence SP600125, a c-Jun...
Protein kinase R (PKR) can suppress various types of solid tumors by inducing cellular oxidative stress and apoptosis. Likewise, Slaidorside, a plant flavonoid, was shown to have anti-tumorigenesis in many tumors.This study evaluated Salidroside HT29 colorectal cancer investigated if the underlying mechanism involves activation PKR.Control or PKR deficient cells were cultured DMEM media treated with 100 μM cell survival, apoptosis, other biochemical-related markers evaluated.Salidroside...
The study examined the protective effect of exogenous administration dehydroepiandrosterone (DHEA) against acetaminophen (APAP) -induced liver damage in rats and tested underlying mechanism(s). Male were divided into 5 groups as control, control + DHEA, APAP, APAP DHEA EX-527 (SIRT1 inhibitor). Treatments conducted for 10 days then followed by intragastric a single dose APAP. not only reduced serum alanine transaminase (ALT) aspartate aminotransferase (AST) but also preserved structures....
Diabetes mellitus (DM) is a chronic metabolic disease. Olive leaves consists of phenolic compounds, flavonoids and volatile oil. The aim this study was to evaluate the anti-diabetic curative effect olive extract on streptozotocin-induced diabetic rats. Forty male rats were divided into 4 groups, Group I; Animals served as control. II; received oral (OLE) 0.5 mg/kg body weight/day. III; injected intraperitoneally with single dose streptozotocin (STZ) (45mg /kg weight) induce diabetes. IV,...
Objective: To investigate the hepatorenoprotective effects of Origanum vulgare L. against finasteride-induced oxidative injury in liver and kidney mice. Methods: Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI/MS) analysis was utilized to yield a fingerprint polyphenolic constituents. Thirty BALB/c mice received 0.5 mL/day distilled water, finasteride (25 mg/kg/day for 10 d), 100, 200, or 400 + extract with 6 per group five weeks. On day 36, function as well...
Background: cervical spondylosis and forward head posture are the most common musculoskeletal problems among society.Few studies investigating effect of FHP on proprioception function.Objective: The study aimed to determine relationship between (FHP) function in patients with detect severity function.Patients Methods: sixty from both sex were participated study.Their age ranged 30-50 years old.Patients divided into three equal groups; Mild group (GI), moderate (GII) severe (GIII) according...
The increased usage of chemicals and other harmful compounds has contaminated air, water, soil, food, endangering life. This threat grown with fast industrialization exponential population expansion. Because agricultural runoffs contain pesticide fertilizer residues, they have a negative impact on the quality surface ground water. goal current article is to gather data pollution in aquatic environments its potential impacts fish human health. causes acute toxicity which effect health,...
Introduction: Anticholinesterase poisoning is a major global health problem with thousands of deaths each year.Determination prognosis concern for clinical toxicologists.Previous studies reported that cortisol and thyroid stimulating hormone (TSH) may have prognostic role in patients poisoned by organophosphates.Aim the work: Evaluation TSH acute anticholinesterase pesticides admitted to Tanta Poison Control Center.Methodology: This prospective study included 29 moderate severe according...
This study examined if the anti-tumorigenesis effect of Exendin-4 in HT29 and HCT116 colorectal cancer (CRC) involves modulation SIRT1 Akt/GSR3K/β-catenin/NF-κB axis. cells were treated either with increasing levels (0.0-200 µM) or (at its IC50) presence absence EX-527 (10 µM/a selective inhibitor) (9-39) amide (E A) (1 µM/an antagonist). In a dose-dependent manner, inhibited cell survival, but enhanced lactate dehydrogenase (LDH) single-stranded DNA (ssDNA) both HCT116. lines at it has an...
This study investigates if the anti-tumor effect of Pterostilbene in SKOV3 ovarian cancer (OC) cell line involves inhibition metabolism and tested this modulating AMPK Akt-induced regulation mTORC1. Initially, cells were cultured humidified conditions DMEM media for 24 h with or without increasing concentration Pterostilbene. Then, incubated (IC50 = 50 µM) under similar pre-incubation Dorsomorphin, an inhibitor. In a dose-dependent manner, inhibited survival increased their lysate levels...