<i>Background:</i> While atrial fibrillation (AF) increases the risk of cardioembolic stroke, some ischemic strokes in AF patients are noncardioembolic. <i>Objectives:</i> To assess stroke mechanisms and to compare their responses antithrombotic therapies. <i>Methods:</i> On-therapy analyses occurring 3,950 participants Stroke Prevention Atrial Fibrillation I–III clinical trials. Strokes were classified by presumed mechanism according specified neurologic...

Background.— Many migraineurs report attack “triggers,” but relatively few published data exist regarding the relative prevalences of individual triggers, variations related to gender, duration migraine or subtype, existence any regional in and distributions triggers. Objective.— We sought determine prevalence types triggers our clinic population, what influence might have on reported compare findings with derived from surveys we previously had conducted involving 2 clinic‐based populations...

To compare effectiveness of onabotulinumtoxinA and topiramate for chronic migraine (CM) prevention.The efficacy* has been established in placebo-controlled randomized clinical trials (*defined as the benefit treatment under ideal conditions). The effectiveness* 2 preventive treatments, however, not (*the real-world conditions, representing a blend efficacy tolerability).In this multicenter, randomized, parallel-group, post-authorization, open-label prospective study (FORWARD;...

Intracranial hemorrhage and ischemic stroke have been reported to complicate oral or intravenous use of methamphetamine. We report three cases following methamphetamine inhalation.

Twenty-two patients with acute migraine-associated stroke were prospectively evaluated; 91% female, and 23% had a prior history of presumed migrainous stroke. The incidences major risk factors mitral valve prolapse no higher for the study group than general population similar age. Computed tomography, magnetic resonance imaging, or radionucleotide scanning brain was performed on all patients, demonstrated ischemic hemorrhagic infarction in 12 (55%). Cerebral arteriography revealed...

Objective.—To determine whether the addition of patient education to routine medical management improves clinical status migraine patients and reduces their utilization healthcare resources. Background.—Optimal typically requires effective education. Such often is difficult accomplish in busy clinic setting. Methods.—One hundred consecutive with presenting an university‐based headache were randomized receive or not a standardized course didactic instruction regarding biogenesis management....

The treatment of a migraine attack can be difficult when first-line medication is unsuccessful and options for parenteral "rescue" therapy are limited.A randomized, double-blind, placebo-controlled, dose-ranging, multicenter study was conducted to assess the efficacy tolerability droperidol 0.1 mg, 2.75 5.5 8.25 mg acute moderate severe headache in adults.A total 331 patients were enrolled; 305 treated. Headache response at 2 hours better (p < 0.002) groups receiving IM doses (87%), (81%),...

This study assesses the concordance in migraine diagnosis between an online, self-administered, Computer-based, Diagnostic Engine (CDE) and semi-structured interview (SSI) by a headache specialist, both using International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria.Delay accurate is major barrier to care. Accurate computer-based algorithms may help reduce need for SSI-based encounters arrive at correct ICHD-3 diagnosis.Between March 2018 August 2019, adult...

Thirty-one patients with presumed lacunar stroke, recent (18 patients) or remote (13 patients), were evaluated brain magnetic resonance imaging (MRI). MRI detected small, deep lesions appropriate to symptoms in 23 of the (74%) and was diagnostically superior computed tomography (CT) those cases where both studies obtained acutely. also appeared useful distinguishing between acute chronic ischemic lesions. Especially setting suspected infarction, MRI, when available, should replace CT as...

Approximately 1 in 50 Americans is afflicted by chronic migraine (CM). Many patients with CM describe cervicogenic headache. Options for treating effectively are at present quite limited.To determine the safety and efficacy of occipital nerve blocks (ONBs) used to treat (CCM) identify variables predictive a positive treatment response.Using uniform dose injection paradigm, we performed ONBs consecutively on series presenting CCM. Patients were stratified according specific findings found be...

We followed 2 patients with extracranial internal carotid dissection and associated occlusion or preocclusive stenosis serial magnetic resonance duplex examinations. These studies demonstrated progressive anatomic resolution in both cases.

Objective To determine whether the utilization of healthcare resources is reduced after chronic migraine patients are treated for 6 months with onabotulinumtoxin A . Background Onabotulinumtoxin indicated headache prophylaxis in migraine, but its effect on resource use unknown. Methods We analyzed data from an open‐label study 230 refractory to ≥2 oral prophylactics who presented a specialty clinic and were two cycles Frequency cost migraine‐related use, including visits emergency...

Two patients with an established history of migraine developed persistent aura symptoms that ceased after the initiation treatment divalproex sodium. <b>NEUROLOGY 1997;48: </b> 261-262

Background and Purpose As the US minority population continues to grow, increasing numbers of nonwhite citizens are at risk for stroke. A better understanding how ischemic stroke differs in populations may lead more effective clinical management. Methods We prospectively evaluated 542 consecutive patients (416 whites, 71 Mexican Americans, 55 blacks) presenting University California San Diego Medical Center or Veterans Affairs Hospital with presumed acute transient attack. Results Whites had...

Background.—Borderline personality disorder (BPD) may be disproportionately common in the migraine patient population, but specific features BPD subgroup remain incompletely characterized. Purpose.—To define more clearly clinical characteristics of patients with BPD, to evaluate their response aggressive headache management, and assess sensitivity an instrument intended screen for presence BPD. Methods.—We evaluated 50 consecutive previously documented all types no history matched first...

Whether acute anticoagulation after cardioembolic stroke affords substantial protection against early recurrent emboli or an unacceptable risk of hemorrhage remains controversial. To assess this further, we evaluated 121 consecutive patients with stroke. Forty-nine were therapeutically anticoagulated within 96 hours onset, and 41 received no anticoagulants the first 2 weeks These two groups did not differ significantly regard to age, sex, severity neurologic deficit, spectrum underlying...

Stroke databanks may provide important information regarding regional and temporal variations in the causes of stroke.Five hundred consecutive patients presenting to University California, San Diego, stroke services with acute ischemic were evaluated prospectively. A specific cause was assigned each case according predetermined diagnostic criteria.Relative incidences as follows: lacunar, 27%; unknown cause, 23%; cardioembolic, 22%; large-vessel atherothrombotic/embolic, 18%; miscellaneous,...

Duplex ultrasonography combining high-resolution imaging and Doppler spectrum analysis was performed in 92 consecutive patients (total, 180 vessels) compared with the findings of conventional arteriography. All duplex studies were categorized into four groups based upon maximum internal carotid artery (ICA) velocity: group 1: less than 125 cm/sec; 2: to 224 3: greater 225 4: no flow. Sensitivities specificities highest when peak ICA velocity used as one several criteria quantifying degree...

Chronic migraine (CM) is associated with impaired health-related quality of life and substantial socioeconomic burden, but many people CM are underdiagnosed do not receive appropriate preventive treatment. OnabotulinumtoxinA topiramate have demonstrated efficacy (treatment benefit under ideal conditions) for the prevention headaches in clinical trials, real-world studies suggest markedly different effectiveness based on a blend tolerability). This study sought to evaluate patient-reported...

We compared data from 243 patients with episodic migraine (EM) and 132 chronic daily headache (CDH). divided the latter group into those tension-type only (CDH Type 1) headaches having migrainous features Types 2 + 3) each EM all three groups one another. CDH 1 differed in other by virtue of gender (more often male) mean age at onset (older). The 3 that former were more likely to have undergone a brain-imaging study. These suggest may represent distinct syndrome, while closely resemble migraine.