A5084261325- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Surgical Treatments
- Advances in Oncology and Radiotherapy
- Genetic factors in colorectal cancer
- Breast Implant and Reconstruction
- Cancer survivorship and care
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Air Quality and Health Impacts
- Clinical practice guidelines implementation
- Global Maternal and Child Health
- Patient Satisfaction in Healthcare
- Healthcare Policy and Management
- Biomarkers in Disease Mechanisms
- Energy and Environment Impacts
- Global Health and Surgery
- COVID-19 and healthcare impacts
- Ferroptosis and cancer prognosis
- Health disparities and outcomes
- Ureteral procedures and complications
- Childhood Cancer Survivors' Quality of Life
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
NHS Digital
2023
NHS England
2023
Public Health England
2022
University of Manchester
1998-2017
Médecins Sans Frontières
2016
Manchester Academic Health Science Centre
2015
Stockport NHS Foundation Trust
1998-2008
Cancer Research UK Manchester Institute
1998
Evidence suggests that compared to younger women, older women are less likely receive standard management for breast cancer. Whether this disparity persists once differences in tumour characteristics have been adjusted has not investigated the UK. A retrospective cohort study involving case note review was undertaken, based on North Western Cancer Registry database of aged ⩾65 years, resident Greater Manchester with invasive cancer registered over a 1-year period (n=480). Adjusting...
Evidence suggests that physical activity improves quality of life and functioning among breast cancer patients survivors. However, previous studies have tended to focus on younger patients, despite higher incidence lower survival older In this study we explored preferences survivors inform the development future targeted interventions. Twenty-nine female (1 5 years postdiagnosis) aged 59 86 (mean 66.54, SD 6.50) took part in either a semistructured interview or group exploring patterns,...
Abstract Background Older women are less likely to receive standard management for breast cancer than younger postmenopausal women. Whether differences in general health explain variations the rates of surgery is not known. Methods In this prospective cohort study, 76 aged 65 years or more attending units Greater Manchester completed a survey measuring functional status (Elderly Population Health Status Survey's Activity Daily Living), generic (Short Form 12) and health-related quality life...
Older women have lower breast cancer surgery rates than younger women. UK policy states that differences in treatment by age can only be justified patient choice or poor health. We investigate whether lack of for older patients is explained choice/poor health a prospective cohort study 800 aged ⩾70 years diagnosed with operable (stage 1–3a) at 22 English units 2010–2013. Data collection: interviews and case note review. Outcome measure: <90 days diagnosis. Logistic regression adjusts age,...
Around 60% of women ⩾80 years old, in the UK do not have surgery for their breast cancer (vs<10% younger age groups). The extent to which this difference can be accounted by co-morbidity has been established. A Cancer Registry/Hospital Episode Statistics-linked data set identified aged ⩾65 diagnosed with invasive (between 1 April 1997 and 31 March 2005) two regions (n=23 038). Receipt was investigated using logistic regression, adjusting other patient, tumour treatment factors. Overall, 72%...
Objective Surgery is the mainstay of treatment for breast cancer. However, there evidence that older women are not receiving this treatment. This study explores reasons why having surgery. Methods Twenty eight in-depth interviews were conducted with over 70 years old operable cancer primary endocrine therapy (PET) as their The focused on perceptions they being treated PET rather than Transcripts analysed using Framework method. Results Based PET, patients divided into three groups: ‘Patient...
Sebaceous carcinomas (SC) may be associated with the cancer predisposition syndrome Muir-Torre/Lynch (MTS/LS), identifiable by SC mismatch repair (MMR) screening; however, there is limited data on MMR status of SC.To describe epidemiology SC, copresentation other cancers, and population level frequency screening in SC.A population-based retrospective cohort study patients National Cancer Registration Analysis Service England.This included 1077 cases (739 extraocular, 338 periocular)....
Studies largely from the market research field suggest that inclusion of a stamped addressed envelope, rather than pre-paid business reply, increases response rate to mail surveys. The evidence this is also case regarding patient surveys limited.The aim study investigate whether envelopes increase rates compared reply and compare relative costs. A sample 477 initial non-responders survey patients attending breast clinics in Greater Manchester between 1/10/2002 - 31/7/2003 were entered into...
Abstract Background Elderly patients with breast cancer are less likely to be offered surgery, partly owing co-morbidities and reduced functional ability. However, there is little consensus on how best assess surgical risk in this patient group. Methods The ability of pretreatment health measures predict complications was investigated a prospective cohort study consecutive series women aged at least 70 years undergoing surgery for operable (stage I–IIIa) 22 English units between 2010 2013....
Abstract Environmental carcinogenic exposures are major contributors to global disease burden yet how they promote cancer is unclear. Over 70 years ago, the concept of tumour promoting agents driving latent clones expand was first proposed. In support this model, recent evidence suggests that human tissue contains a patchwork mutant clones, some which harbour oncogenic mutations, and many environmental carcinogens lack clear mutational signature. We hypothesised carcinogen, <2.5μm...
Background: Surgical site infection (SSI) after a Cesarean section (CS) increases maternal morbidity and medical costs.No data regarding the epidemiology of SSI CS are available in settings operated by Médecins Sans Frontières.Objectives: To determine incidence independent risk factors for CS, as well pathogens associated with infections.Methods: A prospective collection among women undergoing was conducted 43-bed maternity ward hospital Haiti.Infections were identified during stay or...
Background: The occurrence of cancer during pregnancy is uncommon with an incidence rate ∼1 in 1000 pregnancies. pregnancy-associated increasing and this partly caused by a trend delaying child bearing to older age. Aim: With little data the UK concerning number women diagnosed pregnancy, purpose study was compare pregnant general female population. Methods: Cancer registry for England were linked hospital activity establish cancers. For study, aged 15 44 years malignant between 2012 2014 or...
Meta-analysis of the effect goal-directed therapy on bowel
Abstract Introduction Lack of surgery for older breast cancer patients may reduce survival. Previous studies did not adjust comorbidity and tumour characteristics which affect Methods In a prospective cohort study investigating patients' treatment, survival analyses (mean 3.8 years, 95% CI: 3.69-3.83) was undertaken 910 aged ≥65 years diagnosed at 22 English hospitals from 1/7/10 to 31/12/12. Primary outcome specific Independent variables included surgery, comorbidity, functional status...