A5040740942- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Dietary Effects on Health
- Genetics and Neurodevelopmental Disorders
- Cholinesterase and Neurodegenerative Diseases
- Studies on Chitinases and Chitosanases
Columbia University Irving Medical Center
2023-2024
Columbia University
2021
Abstract Mutations in Cullin-3 ( Cul3 ), a conserved gene encoding ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific knockdown Drosophila . We confirmed that neuronal causes short sleep, paralleling sleep disturbances ASD. Because defects and ASD linked to metabolic dysregulation, tested the starvation response of flies; they starved faster had lower triacylglyceride levels than controls,...
Inhibitors of enzymes that inactivate amine neurotransmitters (dopamine, serotonin), such as catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), are thought to increase neurotransmitter levels widely used treat Parkinson's disease psychiatric disorders, yet the role these in regulating behavior remains unclear. Here, we investigated genetic loss a similar enzyme model organism Drosophila melanogaster. Because Ebony modifies inactivates neurotransmitters, its is assumed levels,...
In previous work, we found that short sleep caused sensitivity to oxidative stress; here set out characterize the physiological state of a diverse group chronically short-sleeping mutants during hyperoxia as an acute stress. Using RNA-sequencing analysis, had normal transcriptional stress response relative controls. both and controls, led downregulation glycolytic genes upregulation involved in fatty acid metabolism, reminiscent metabolic shifts sleep. We hypothesized may be sensitive...