Abstract Objective Our primary objective was to evaluate the safety and feasibility of transcranial direct current stimulation combined with exercise therapy for treatment cervicogenic headache. exploratory objectives compared symptoms headache, mood, pain, quality life between active sham therapy. Background Cervicogenic headache arises from injury cervical spine or degenerative diseases impacting structure resulting in reduced life, impaired function. Current standard‐of‐care treatments...

Elevated glial fibrillary acidic protein (GFAP) in the blood serum is one of promising bodily fluid markers for diagnosis central nervous system (CNS) injuries, including traumatic brain injury (TBI), stroke, and spinal cord (SCI). However, accurate point-of-care (POC) quantification GFAP clinical samples has been challenging yet to be clinically validated against gold-standard assays outcome practices. This work engineered characterized a novel nanoporous carbon screen-printed electrode...

This study evaluated the in vitro and vivo pharmacological properties of TD-8954, a potent selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, selectivity (> 2,000-fold) over all other 5-HT receptors non-5-HT ion channels, enzymes transporters tested (n 78). produced an elevation cAMP HEK-293 cells expressing h5-HT4(c) (pEC50 9.3), contracted guinea pig colonic longitudinal muscle/myenteric plexus (LMMP) preparation...

Objective The objectives of this study were to evaluate functional outcomes cervical motor control, strength and endurance following active transcranial direct current stimulation (tDCS) with exercise therapy (ET) compared sham tDCS/+ET in patient cervicogenic headache (CGH), Design This was a pilot sham-controlled, participant assessor blinded, randomized controlled trial. Methods Thirty-two participants CGH or tDCS/+ET. Participants completed 6-weeks daily ET concurrently combined 3...

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Abdominal pain-related pediatric functional gastrointestinal disorders (AP-FGIDs) are defined by abdominal discomfort or pain that may provide obstacles to everyday activities, such as school attendance. It has been reported AP-FGID symptoms be reduced in summer, but it is unclear what drives this seasonal variation. This pilot study aimed explore whether the variation could explained various psychological and behavioral factors.Parents of children with completed online questionnaires on...

Charles Bonnet syndrome (CBS) describes the presence of hallucinations in patients with poor or deteriorating vision. The physician awareness CBS is low, despite reporting occurring a range ocular and central nervous system conditions. Following mild traumatic brain injury (mTBI), can experience visual oculomotor dysfunction. As such, it possible that might present following mTBI. An adult male suffered an mTBI whiplash motor vehicle accident. He developed persistent post-concussion symptoms...

Abstract Background Post-traumatic headaches (PTH) are a common sequelae of traumatic brain injury (TBI) and greatly impact patient function quality life. greater occipital neuralgia (GON) is type post-traumatic headache. Conventional treatment includes steroid/anesthetic injections which typically alleviate pain but have short duration effect. Platelet-rich plasma (PRP) an emerging biological for numerous degenerative disorders, including peripheral nerve disorders. The primary aim this...

Approximately one-third of all concussions lead to persistent postconcussion syndrome (PPCS). Repetitive transcranial magnetic stimulation (rTMS) is a form noninvasive brain that has been extensively used treat refractory major depressive disorder and strong potential be as treatment for patients with PPCS. Functional near-infrared spectroscopy (fNIRS) already tool assess PPCS may provide insight into the pathophysiology rTMS in PPCS.The primary objective this research determine whether...

Background Treatment for post-traumatic greater occipital neuralgia (GON) includes serial injections of steroid/anesthetic. While these can alleviate pain, effects be transient, frequently lasting only 1 month. As a potential alternative, platelet-rich plasma (PRP) are an emerging biological treatment with beneficial in peripheral nerve disorders. We investigated the feasibility, safety, and effectiveness single PRP injection GON comparison to saline or steroid/anesthetic injection. Methods...

Objective This study explores the relationship between PTSD symptoms and cognition in patients with persistent post-concussive (PPCS).

<b>Introduction:</b> Ambulatory oxygen (O₂) is recommended treatment for hypoxaemia at rest or induced by exercise. Commercial aircraft cabins are pressurized to altitudes of 6,000-8,000 feet, with an equivalent FiO₂ 15%. O₂ supplementation, those on baseline ambulatory O₂, paramount. <b>Aims and Objectives:</b> To gather information patients9 experience travelling supplementary reasons patients do not travel. <b>Methods:</b> Patients were...

Platelet serotonin (5‐hydroxytryptamine, 5‐HT) is released upon platelet activation and serves as a proaggregatory factor. Clinical preclinical evidence suggest that selective reuptake inhibitors (SSRIs) deplete 5‐HT reduce aggregation. The goal of this study was to determine if inhibition the transporter (SERT) reduces improves survival in mouse thromboembolism (MTE) model. C57/BL6 mice were treated with vehicle (veh), fluoxetine (FX, 30 mg/kg, PO x 1 &amp; 7d), paroxetine (PX, escitalopram...

Abstract Background Cervicogenic headaches (CGH) are common following concussion and whiplash injuries significantly reduce patient quality of life. CGH is often associated with neck, jaw and/or facial pain reduced neck mobility. Conservative therapy injection-based therapies cornerstones treatment for but have shown limited efficacy. Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has promise in treating other chronic headache conditions. The aim this trial...

Abstract Background : Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Post-traumatic headaches (PTH) are common sequalae TBI greatly impact patient function quality life. greater occipital neuralgia (GON) type post-traumatic headache. Conventional treatment includes steroid/anesthetic injections which typically alleviate pain, but have short duration effect. Platelet rich plasma (PRP) an emerging biological for numerous degenerative disorders, including...

<sec> <title>BACKGROUND</title> Approximately one-third of all concussions lead to persistent postconcussion syndrome (PPCS). Repetitive transcranial magnetic stimulation (rTMS) is a form noninvasive brain that has been extensively used treat refractory major depressive disorder and strong potential be as treatment for patients with PPCS. Functional near-infrared spectroscopy (fNIRS) already tool assess PPCS may provide insight into the pathophysiology rTMS in </sec> <title>OBJECTIVE</title>...

Abstract Background : Post-traumatic headaches (PTH) are a common sequalae of TBI and greatly impact patient function quality life. greater occipital neuralgia (GON) is type post-traumatic headache. Conventional treatment includes steroid/anesthetic injections which typically alleviate pain but have short duration effect. Platelet rich plasma (PRP) an emerging biological for numerous degenerative disorders, including peripheral nerve disorders. The primary aim this pilot study to evaluate...