A5076037816- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Global Maternal and Child Health
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Angiogenesis and VEGF in Cancer
- Neonatal Respiratory Health Research
- Pelvic floor disorders treatments
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Maternal and Neonatal Healthcare
- Developmental Biology and Gene Regulation
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Vascular Malformations Diagnosis and Treatment
- Ovarian function and disorders
- Ureteral procedures and complications
- Folate and B Vitamins Research
- Hormonal Regulation and Hypertension
- Fetal and Pediatric Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Lymphatic System and Diseases
Hospital de Santa Maria
2013-2022
CUF Porto Hospital
2022
Centro Hospitalar Lisboa Norte
2013-2019
University of Lisbon
1999-2017
Instituto Gulbenkian de Ciência
2007
Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct ligands. Using a coculture assay we observed that ligand Delta-1 completely inhibits differentiation human hematopoietic progenitors into lineage while promoting emergence cells with phenotype cell/natural killer (NK) precursors. In contrast, Jagged-1 did not disturb either or cell/NK development. Furthermore,...
Anemia and iron deficiency during pregnancy are a worldwide concern more frequent among women of reproductive age, pregnant women, young children. The aim this study was to assess the prevalence anemia risk factors for depletion first half pregnancy, in Portuguese population.A prospective conducted at tertiary hospital included until 20th week gestation. Data collected regarding demographic features hemoglobin serum ferritin concentrations were determined. A multivariate logistic regression...
Article Acute effects of maternal cigarette smoking on fetal heart rate and body movements felt by the mother was published January 1, 1991 in journal Journal Perinatal Medicine (volume 19, issue 5).
It has been shown that Notch signaling mediated by ligands of both Jagged and Delta families expands the hematopoietic stem cell compartment while blocking or delaying terminal myeloid differentiation. Here we show Delta1‐ Jagged1‐expressing stromal cells have distinct effects on clonogenic differentiation capacities human CD34+ CD38+ cells. Jagged1 increases number bipotent [colony‐forming unit‐granulocyte macrophage (CFU‐GM) unipotent progenitors (CFU‐granulocytes CFU‐macrophages), without...
The role of intrapartum ultrasound as an ancillary method to instrumental vaginal delivery is yet be determined. This study aimed compare the use transabdominal and transperineal with routine clinical care before performing delivery, regarding incidence adverse maternal neonatal outcomes.A randomized controlled trial was conducted between October 2016 March 2019 in two tertiary maternity hospitals Lisbon, Portugal. Women at term, full cervical dilatation, singleton fetuses cephalic...
Introduction: The best route of delivery for the term breech fetus is still controversial. We aim to compare maternal and neonatal outcomes between vaginal cesarean deliveries.Material Methods: Multicentric retrospective cohort study singleton fetuses delivered vaginally or by elective section from January 2012 - October 2014. Primary were morbidity mortality.Results: Sixty five compared 1262 cesarean. Nulliparous women more common in group (69.3% vs 24.6%; p < 0.0001). Gestational age at...
Background: Ovarian hyperstimulation syndrome, not related to ovulation induction, is rare. A MEDLINE search from 1987 1997 using the key words "spontaneous ovarian stimulation," "pregnancy," and "hypothyroidism" revealed only five cases: three associated with pregnancies two primary hypothyroidism. Case: 25-year-old white gravida 2, para 1, at 11–12 weeks' gestation presented mild distension of a nontender abdomen, myxedematous facies, large bilateral, multilobulated cysts. Conception had...
Objective: The aim of our study is to evaluate the clinical importance near term weight discordance in twin pregnancies with both appropriate or one small for gestational age newborn (AGA and SGA, respectively).
Aneurysms of the vein Galen (AVG) represent less than 1% all intracranial arteriovenous malformations. Two cases prenatal diagnosis made by color Doppler ultrasonography at 32 weeks gestation are reported. Both presented with antenatal mild cardiomegaly and both developed severe cardiac failure in neonatal period. Embolization was unsuccessful infants died. These highlight need for a careful evaluation time mode delivery; embolization must be performed after fully informed decision.
Introduction: To analyze the cesarean section rate evolution in a tertiary hospital and main indications for section.Material Methods: A retrospective study was conducted at major academic included 5 751 women who had from 2005 to 2011. The rates of overall, primary repeat sections were analyzed. linear regression adjusted R-square used access relative contribution each indication variation section.Results: During 7-year period decreased 30.9% 27.6%. This due decrease (21.9% 18.2%), although...
Introduction: Foley catheter promotes cervix priming by a direct mechanical effect of distension.Material and Methods: A prospective observational study was conducted at tertiary hospital, including all cases induction labor with between September 1, 2013 November 30, 2015. Women were eligible if they had singleton pregnancy Bishop score < 6 gestational age ≥ 41 weeks or medical indication for labor. The primary outcome the variation (difference before after insertion catheter). Mode...
Introduction: Physical exercise at term is empirically used as a method of enhancing the spontaneous labor onset. The objective this study was to evaluate effect controlled maternal physical onset.Materials and methods: At 38 weeks low-risk pregnant women, with singleton cephalic fetus no previous cesarean deliveries were randomly allocated one two arms: experimental group performed 30 min walking 3 times week 4 km/h, control maintained their usual work household activities. primary outcome...
Abstract Objective The Robson 10 group classification system (RTGCS) is a reproducible, clinically relevant and prospective proposed by the World Health Organization (WHO) as global standard for assessing, monitoring comparing cesarean section (CS) rates. purpose of present study to analyze CS rates according RTGCS over 3-year period identify main contributors this rate. Methods We reviewed data regarding deliveries performed from 2014 up 2016 in tertiary hospital Portugal, classified all...