A5058857594- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Polymer composites and self-healing
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Advanced Materials and Mechanics
- Fiber-reinforced polymer composites
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Glycosylation and Glycoproteins Research
- Additive Manufacturing and 3D Printing Technologies
- Dyeing and Modifying Textile Fibers
- Biochemical and Structural Characterization
- Platelet Disorders and Treatments
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Photochromic and Fluorescence Chemistry
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
University of Bologna
2015-2020
University of Brescia
2018
Pseudopeptides containing the d-Oxd or d-pGlu [Oxd = (4R,5S)-4-methyl-5-carboxyl-oxazolidin-2-one, pGlu pyroglutamic acid] moiety and selected amino acids were used as low-molecular-weight gelators to prepare strong thixotropic hydrogels at physiological pH. The addition of calcium chloride gelator solutions induces formation insoluble salts that get organized in fibers a pH close one. Physical characterization was carried out by morphologic evaluation rheological measurements demonstrated...
Four new low molecular weight hydrogelators (LMWGs) have been prepared in multigram scale and their attitude to form hydrogels has tested. The gelation trigger is pH variation. resulting gels characterized with several techniques: measurement of the melting points (T(gel)), transparency, time, viscoelastic properties, together ECD analysis. Among them, Fmoc-L-Tyr-D-Oxd-OH 1 an excellent gelator that leads preparation strong, transparent, gels, by UV-visible analyses demonstrated obtained...
Atmospheric pressure non‐equilibrium plasma treatments of poly(vinylidene fluoride) (PVdF) solutions and electrospun Li‐ion separators are implemented to improve fiber morphology increase electrolyte uptake. Plasma pre‐treatment PVdF increased the viscosity induced a morphological change polymer chains, enabling production defect‐free mats with improved mechanical properties compared those produced from non pre‐treated solutions. The post‐treatment separator chemical modification surface an...
Nine amino acids with different chemical properties have been chosen to promote the formation of hydrogels based on bolamphiphilic gelator <bold>A</bold>: three basic (arginine, histidine and lysine), one acidic acid (aspartic acid), two neutral aliphatic (alanine serine) aromatic (phenylalanine, tyrosine tryptophan).
Regulating stem cell adhesion and growth onto functionalized biomaterial scaffolds is an important issue in the field of tissue engineering regenerative medicine. In this study, new electrospun poly(l-lactic acid) (PLLA), as bioresorbable polymer, β-lactam compounds agonists selected integrins, functional components with adhesive properties, are designed. The β-lactam-PLLA contribute significantly guiding protein translation involved human bone marrow mesenchymal cells (hBM-MSC) integrin...
Nonwoven fibrous mats based on semicrystalline networks are prepared starting from poly(ε‐caprolactone) and properly combining electrospinning sol–gel reactions. The obtained as continuous, randomly oriented micrometric fibers with different network densities. systems subjected to thermomechanical cycles investigate their one‐way two‐way shape memory behavior. One‐way tests aim at exploring the effects of deformation temperature materials response, particular interest less investigated...
Abstract We present herein the preparation of four different hydrogels based on pseudopeptide gelator Fmoc‐ l ‐Phe‐ d ‐Oxd‐OH (Fmoc=fluorenylmethyloxycarbonyl), either by changing concentration or adding graphene oxide (GO) to water solution. The have been analysed rheological studies that demonstrated pure are slightly stronger compared GO‐loaded hydrogels. Then efficiency trap cationic methylene blue (MB) and anionic eosin Y (EY) dyes has analyzed. MB is efficiently trapped both hydrogel...
A smart combination of electrospinning and sol–gel reaction enabled to develop crosslinked poly(ε-caprolactone) fibrous mats showing excellent shape memory properties.
A biodegradable and biocompatible electrospun scaffold with shape memory behavior in the physiological temperature range is here presented. It was obtained starting from a specifically designed, biobased PLLA-based triblock copolymer, where central block poly(propylene azelate-co-propylene sebacate) (P(PAz60PSeb40)) random copolymer. Shape properties are determined by contemporary presence of low melting crystals P(PAz60PSeb40) block, acting as switching segment, high crystal phase PLLA...
Non-woven fibrous mats based on semicrystalline networks were prepared starting from poly(ε-caprolactone) and by combining electrospinning process sol-gel crosslinking reaction. The subjected to proper thermo-mechanical cycles investigate their two-way shape memory capabilities (i.e. the possibility change between two distinguished shapes upon heating cooling), an improvement of behaviour was researched through application a training cycle. An ex-situ SEM analysis described microstructural...
In this work we have explored the capabilities of an electrospun mat, realized in crosslinked poly(ε-caprolactone), to be employed as a scaffold for specific biological applications. Its shape memory behavior was here exploited easily control fiber orientation and guide cellular alignment. Randomly oriented mats were transformed stable with various degrees alignment by simply varying maximum strain applied throughout proper thermo-mechanical cycles. The effect investigated both on mechanical...
Event Abstract Back to Shape memory properties of electrospun non-woven mat prepared from sol-gel crosslinked poly(e-caprolactone) Andrea Merlettini1, Stefano Pandini2, Maria Letizia Focarete1, Chiara Gualandi1, Maurizio Toselli3, Massimo Messori4, Silvia Agnelli2 and Katia Paderni4 1 University Bologna, Department Chemistry "G.Ciamician", Italy 2 Brescia, Mechanical Industrial Engineering, 3 “Toso Montanari”, 4 Modena Reggio Emilia, Engineering “E. Ferrari” INSTM Udr, Memory Polymers are a...