A5016872898- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Pharmaceutical Practices and Patient Outcomes
- Opioid Use Disorder Treatment
- Receptor Mechanisms and Signaling
- Emergency and Acute Care Studies
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Health Policy Implementation Science
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Tryptophan and brain disorders
- Criminal Justice and Corrections Analysis
- Cannabis and Cannabinoid Research
- Advanced Chemical Sensor Technologies
- Health, psychology, and well-being
- Antioxidant Activity and Oxidative Stress
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Assays
- Interprofessional Education and Collaboration
- Schizophrenia research and treatment
- Pharmaceutical Economics and Policy
- Analytical Chemistry and Chromatography
Duke University
2006-2024
Allen Institute for Brain Science
2018
Institute of Behavioral Sciences
2018
Duke Medical Center
2007-2014
Duke University Hospital
2007-2014
Durham VA Medical Center
2008
Vanderbilt University
2005-2006
Vanderbilt University Medical Center
2004
The bed nucleus of the stria terminalis (BNST) is a key component CNS stress and reward circuit. Synaptic plasticity in this region could part underlie persistent behavioral alterations generalized anxiety addiction. Group I metabotropic glutamate receptors (mGluRs) have been implicated stress, addiction, synaptic plasticity, but their roles BNST are unknown. We find that activation group mGluRs dorsal induces depression excitatory transmission through two distinct mechanisms. First,...
Background: Many people experiment with alcohol and other drugs of abuse during their teenage years. Epidemiological evidence suggests that younger initiates into drug taking are more likely to develop problematic seeking behavior, including binge high‐intake behaviors. The level intake for any individual depends on the balance rewarding aversive effects in individual. Multiple rodent studies have demonstrated reduced adolescent compared adult animals. In this study, we addressed 2 key...
A metabolic system is composed of inherently interconnected precursors, intermediates, and products. The analysis untargeted metabolomics data has conventionally been performed through the use comparative statistics or multivariate statistical analysis-based approaches; however, each falls short in representing related nature perturbations. Herein, we describe a complementary method for large metabolite inventories using data-driven approach based upon self-organizing map algorithm. This...
Emergency department (ED) visits for opioid overdose continue to rise. Evidence-based harm reduction strategies use disorder (OUD), such as providing home naloxone, can save lives, but ED implementation remains challenging.The researchers aimed increase prescribing of naloxone patients with OUD and by employing a model improvement methodology, multidisciplinary team, high-reliability interventions. Monthly rates among discharged OUD-related diagnoses were tracked over time. Interventions...
Drugs of abuse affect behavior by altering neuronal communication within the brain. Previous research examining effects intraperitoneally administered cocaine has revealed that alters excitatory glutamatergic signaling, both directly through regulation synaptic function, and indirectly cellular excitability in areas drug reward circuitry such as nucleus accumbens (NAcc) ventral tegmental area. We have now extended these findings testing hypothesis self-administration might elicit similar...
Background: Alcohol abuse disorders emerge over time with repeated consumption of ethanol, but not all ethanol drinkers develop these disorders. There are pre‐existing characteristics that indicate which most likely to alcohol. Adolescence, novelty seeking, and high stress reactivity among the vulnerable individuals. In addition, an individual’s response his or her first exposure drug influences future consumption. We assessed array behavioral hormonal in adolescent (28‐day‐old) male rats...
Substance use disorders (SUDs) affect millions of Americans. Nevertheless, there is insufficient health care resource allocation for these patients. One reason may be the lack education and training about SUDs in professions programs.The authors developed a required, interprofessional course students completing one-month psychiatry clerkship within Duke University Health System starting November 2015. Students participated six 1-hour class sessions led by an interdisciplinary faculty....
Adolescence is a period of development in neural circuits that are critical for adult functioning. There relationship between alcohol exposure and risky decision-making, though the enduring effects adolescent ethanol on decision-making adulthood have not been fully explored. Studies using positive reinforcement shown intermittent (AIE) results higher levels adulthood, but AIE punishment-mediated Adolescent rats were exposed to or saline vehicle across 16-day period, then allowed mature into...
Background: Substance use disorders (SUDs) are a public health problem affecting millions of Americans. Despite their prevalence, there few care resources allocated for SUDs treatment. Relatively professionals exposed to education in respective programs, which may be one reason this resource insufficiency. In hopes rectifying gap, the authors developed course professions students combining classroom learning with practical application patient care. Methods: The used Bloom's taxonomy...
A growing body of literature demonstrates strong association between poor mental health and criminal recidivism, but research from county jails is limited.Our aim was to examine the relationship re-arrest severe illnesses-schizophrenia, bipolar disorder major depressive disorder-together separately with substance use disorders, as comorbid conditions, in a mid-sized jail cohort southeastern United States.We examined full 8097 individuals who were booked into County Detention Facility 31...
Millions are confined in U.S. jails each year, often with unmet health and social needs. After release, many will visit the emergency department (ED). To illuminate their patterns of ED use, this study linked records from all individuals detained at a Southern urban jail over 5-year period large care system three EDs. Over half used least once, those who received system, 83% visited ED. Jail-involved people made up 4.1% system's users but 21.3% its chronic frequent users. Frequent use was...