A5013294982- Microbial Inactivation Methods
- Virus-based gene therapy research
- Veterinary Oncology Research
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Microfluidic and Bio-sensing Technologies
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Infectious Diseases and Mycology
- Veterinary Orthopedics and Neurology
- Magnetic and Electromagnetic Effects
- Polyamine Metabolism and Applications
- Cutaneous lymphoproliferative disorders research
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Toxin Mechanisms and Immunotoxins
- Veterinary Equine Medical Research
- Pulsed Power Technology Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Bacteriophages and microbial interactions
- Plasma Applications and Diagnostics
- Biomedical and Engineering Education
- Biotechnology and Related Fields
- Poxvirus research and outbreaks
- Safe Handling of Antineoplastic Drugs
New York Oncology Hematology
2016-2024
VA Hudson Valley Health Care System
2012-2013
Society for Immunotherapy of Cancer
2013
Vassar College
2010
American College
2010
Med Center
2005
Syosset Hospital
1998
Abstract Objective —To determine the effect of weight reduction on clinical signs lameness among overweight dogs with and radiographic hip osteoarthritis Design —Nonblinded prospective trial. Animals —9 client-owned that weighed 11 to 12% greater than their ideal body were examined because hind limb lameness. Procedure —Dogs weighed, baseline condition, lameness, function scores assigned. Severity was scored using a numerical rating scale visual analogue scale. Dogs fed restricted-calorie...
To describe the results of electrochemotherapy (ECT) in dogs with mast cell tumours (MCTs) either as first line therapy or an adjuvant to surgery. The treatment combines administration low dose chemotherapeutic drugs application microsecond electric pulses, which cause temporary permeabilization and increased porosity tumour membranes. design this study is a retrospective case series. A total 51 MCTs were included classified according ECT procedure into 4 groups (ECT only, 15 cases,...
Background:Epitheliotropic lymphoma (ELSA) is an uncommon cutaneous canine malignancy of T lymphocytes. A consensus regarding the therapeutic standard care lacking, warranting evaluation chemotherapeutic agents traditionally employed against nodal in treatment ELSA. Hypothesis:The purpose this retrospective, multi‐institutional study was to evaluate efficacy 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) Animals:Forty‐six dogs with adequate follow‐up and response information....
Client-owned pet dogs represent exceptional translational models for advancement of cancer research because they reflect the complex heterogeneity observed in human cancer. We have recently shown that a genetic vaccine targeting dog telomerase reverse transcriptase (dTERT) and based on adenovirus DNA electro-gene-transfer (Ad/DNA-EGT) technology can induce strong cell-mediated immune responses against this tumor antigen increase overall survival affected by B-cell lymphosarcoma (LSA)...
Epitheliotropic lymphoma (ELSA) is an uncommon cutaneous canine malignancy of T lymphocytes. A consensus regarding the therapeutic standard care lacking, warranting evaluation chemotherapeutic agents traditionally employed against nodal in treatment ELSA.The purpose this retrospective, multi-institutional study was to evaluate efficacy 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) ELSA.Forty-six dogs with adequate follow-up and response information.All cases were diagnosed...
Background: Dogs that harbor the naturally occurring ABCB1‐1Δ polymorphism experience increased susceptibility to avermectin‐induced neurological toxicosis as a result of deficient P‐glycoprotein function. Whether or not affects toxicity other substrate drugs has been studied. Hypothesis: possess mutation are more likely develop hematologic associated with vincristine than ABCB1 wild‐type dogs. Animals: Thirty‐four dogs diagnosed lymphoma were included in this study. Methods: Cheek swab...
Transitional cell carcinoma ( TCC ) is the most commonly diagnosed neoplasm in urinary bladder. Distant metastases to regional lymph nodes, lungs, abdominal organs or bones are noted up 50% of dogs at time death. Surgical excision often not practical as typically involve trigone bladder and/or occurs multifocally throughout with field cancerization. Therapeutic approaches very challenging and requirement evaluate alternative therapeutic protocols that may prolong survival times bearing these...
we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA–EGT) technology can induce strong immune response increase overall survival (OS) of dogs affected by multicentric Diffuse Large B cell Lymphoma (DLBCL) when combined to COP therapy in double-arm study. Here, utilized clinically validated device for veterinary electroporation called Vet-ePorator™, Cliniporator™ currently approved Europe...
Feline squamous cell carcinoma (SCC) is currently treated with surgery, radiation therapy and electrochemotherapy (ECT). Both the efficacy and/or safety of ECT were evaluated as a sole bleomycin to treat feline nasal planum SCC (npSCC). Sixty-one cats enrolled. Local treatment response was complete remission (CR), partial (PR) or stable disease (SD). Recurrence rate (RR), disease-free interval (DFI) progression free survival (PFS) calculated. A six-point scale used for toxicity. The median...
Targeted delivery of specific chemotherapeutic drugs into tumors can be achieved by delivering electrical pulses directly to the tumor tissue. This causes a transient formation pores in cell membrane that enables passive diffusion normally impermeant drugs. A novel device has been developed enable endoscopic this permeabilizing treatment. The aim preclinical studies described here was investigate efficacy and safety nonthermal ablation system treatment gastrointestinal cancer models.Murine,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19 pandemic, has been shown to infect a wide range animal species, especially mammals, and besides human-to-human transmission, human-to-animal transmission also observed in some wild animals pets, cats. It demonstrated that cats are permissive susceptible airborne infections. Given high transmissibility potential SARS-CoV-2 different host species close contact between humans animals, it is crucial...
Aim: Cutaneous squamous cell carcinoma (cSCC) is a common disease in patients exposed to UV-light and human papillomavirus. Electrochemotherapy, well-established treatment modality with minimum side effects veterinary medicine, circumvents chemoresistance bleomycin by the use of electric fields. However, are sensitive trauma produced insertion needles that lengthen recovery times, particularly cats nasal planum cSCC. To address this matter, we developed thin-needles electrodes. Methods:...
This prospective experimental simulation study evaluated the efficiency, ease of use (EOU) and cost administering chemotherapy with two closed system transfer devices (CSTD, Equashield™ PhaSeal®) no CSTD. Forty-six veterinary technicians (VT) working in oncology specialty practices were timed during administration simulated water a model canine limb 10 times each EOU likelihood recommending rated by VT using visual analog scales. Costs obtained from distributors. Administration was fastest...
Abstract Fibropapillomatosis of sea turtles is traditionally treated with surgical debulking techniques that are often associated prolonged healing and tumor recurrence. Electrochemotherapy was recently described for green Chelonia mydas can be an alternative to surgery even general anesthesia. The objectives this study were replicate electrochemotherapy protocol from a previous report add plasma bleomycin analysis the treatment. After injection into similarly sized tumors two immediate...
(1998). Fourteen Week Clinical Evaluation of an Oral Antioxidant as a Treatment for Osteoarthritis Secondary to Canine Hip Dysplasia. Veterinary Quarterly: Vol. 20, Voorjaarsdagen Congress 1998, pp. S107-S108.
Meeting abstracts Client-owned pet dogs represent exceptional translational models for advancement of Cancer Research, as they reflects the complex heterogeneity observed in human cancer. We have recently shown that a genetic vaccine targeting dog telomerase (dTERT) and based on Ad/DNA-EGT
Abstract Objective To describe the procedure and outcome of electrochemotherapy (ECT) with bleomycin as a first‐line treatment for bilateral ocular surface squamous neoplasia (OSSN) in eye horse. Animal Studied A client‐owned 5‐year‐old Haflinger gelding limbal‐conjunctival cell carcinoma. Procedures During general local anesthesia, injection tumor was followed by electroporation, applied 15 mm needle electrode, needles held parallel to surface. Results Treatment ECT resulted therapeutic...