A5005427576- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Internet Traffic Analysis and Secure E-voting
- Privacy-Preserving Technologies in Data
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Medical Image Segmentation Techniques
- Effects of Radiation Exposure
- Sulfur-Based Synthesis Techniques
- Information Systems and Technology Applications
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
- Synthesis and Catalytic Reactions
- MicroRNA in disease regulation
- Synthesis of Tetrazole Derivatives
- Cloud Computing and Remote Desktop Technologies
- Neuroscience and Neuropharmacology Research
- Fuel Cells and Related Materials
- Cloud Data Security Solutions
- Spectroscopy and Chemometric Analyses
Agharkar Research Institute
2017-2023
Savitribai Phule Pune University
2017-2023
Queen's University Belfast
2021-2022
University of Mumbai
2016-2021
Considering the increase in cancer cases and number of deaths per year worldwide, development potential therapeutics is imperative. Mesoporous silica nanoparticles (MSNPs) are among nanocarriers having unique properties for drug delivery. Doxorubicin (DOX), being most commonly used drug, can be efficiently delivered to gonadotropin-releasing hormone (GnRH)-overexpressing cells using functionalized MSNPs.We report decapeptide-conjugated MSNPs loaded with DOX targeted delivery breast prostate...
Cancer treatment using siRNA based therapies pose various limitations such as off-target effects and degradation due to lack of specific delivery in desired cells. The aim the present study was develop multifunctional targeted nanoconstructs, which can efficiently precisely deliver silence gene interest LHRH overexpressing cancer Herein, we report development triblock, PAMAM-histidine-PEG dendritic nanoconstructs functionalized with triptorelin (an analog) for breast (MCF-7) prostate (LNCaP)...
Aim: Myocardial infarction is a tissue injury that leads to apoptosis of cardiomyocytes. This can be prevented by using miRNAs, but its delivery cardiomyocytes major hurdle. We aimed deliver miRNAs poly(amidoamine)-histidine (PAMAM-His) nanocarriers prevent apoptosis. Materials & methods: The PAMAM-His nanoparticles were synthesized and assessed for their transfection efficiency in hypoxia/reperfusion-induced H9c2 as well primary cultured Results conclusion: miRNAs-nanoparticle complexes...
The determination of Alzheimer’s disease (AD) from neuroimaging data such as MRI has been immensely researched over the last few years. Recent advances in deep learning a computer perspective have advanced that research. However, general limitations algorithms depend on large number training images, well need to carefully perform construction networks. In past days strategies found great achievement analysis medical imaging. But very little done use turn up and differentiate disease. We are...
Online Social Networks (OSNs) are becoming increasingly important in our day to lives. Statistics show that 74% of the Internet users involved social networking. Unfortunately many us unaware threats and vulnerabilities come with OSNs. These issues can be resolved by using Data Sanitization; process disguising sensitive information overwriting it realistic looking but false data a similar type. The system uses method gibberish word substitution sanitize keywords. Since nouns verbs provide...
Background: RNA interference (RNAi) has emerged as one of the most extensively explored areas research that promising applications in therapeutics. As an endogenous regulatory pathway, RNAi can be used for silencing targeted genes involved progression diseases. Small interfering RNAs (siRNA) are 21-25 nucleotides length and work on principle interference. Owing to their high degree safety, specificity, efficacy, easy synthesis unrestricted choice target, siRNAs considered appropriate gene...
Attack on privacy of the users social media is a known phenomenon. A prominent example this Facebook Beacon and AOL search scandal. networking user also prone to screen scrapping attack. Data Sanitization process disguising sensitive information by overwriting it with realistic looking but false data similar type. We propose system that will take post as inputs provide sanitized outputs where key words are using gibberish word substitution.
Antidepressants are the drugs used to treat depression thereby elevates mood and modifies behavior. The main aims in development of new antidepressants were greater efficacy, absence side effects, lack toxicity over dose earlier onset action. In this study, a series novel substituted benzothiazepine was synthesized evaluated for antidepressant-like activity by using or forced swim test (FST). This study designed synthesized; identify derivatives benzothiazepine. Our synthetic route started...