A5033757419- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Blood disorders and treatments
- Central Venous Catheters and Hemodialysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemostasis and retained surgical items
- Chronic Myeloid Leukemia Treatments
- Vitamin K Research Studies
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Diagnosis and Treatment of Venous Diseases
- Kawasaki Disease and Coronary Complications
- Muscle and Compartmental Disorders
- Cell Adhesion Molecules Research
- Medical and Biological Sciences
- Atrial Fibrillation Management and Outcomes
- Vascular anomalies and interventions
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2017-2024
Ministry of Health of the Russian Federation
2018-2024
Moscow State University
2019
Lomonosov Moscow State University
2019
The ability of platelets to carry out their hemostatic function can be impaired in a wide range inherited and acquired conditions: trauma, surgery, inflammation, pre-term birth, sepsis, hematological malignancies, solid tumors, chemotherapy, autoimmune disorders, many others. Evaluation this impairment is vitally important for research clinical purposes. This problem particularly pronounced pediatric patients, where these conditions occur frequently, while blood volume the choice collection...
Inherited thrombocytopenias are variable in the count and size of platelets, which is related with number receptors intracellular structure. So, reference ranges do not allow interpretation functional disorders, especially macrothrombocytopenias microthrombocytopenias. The flow cytometry diagnostic approach to use values necessary. Seventy-five pediatric patients were divided into three groups by platelet size: 25 normothrombocytopenia ( RUNX1, ANKRD26, ETV6 , CYCS ), microthrombocytopenia...
Immune thrombocytopenia (ITP) is an autoimmune condition primarily induced by the loss of immune tolerance to platelet glycoproteins. Here we develop a novel flow cytometry approach analyze integrin αIIbβ3 functioning in ITP comparison with Glanzmann thrombasthenia (GT) (negative control) and healthy pediatric donors (positive control). Continuous Fura-Red-loaded platelets from whole hirudinated blood was used for characterization responses conventional activators. Calcium levels fibrinogen...
Childhood essential thrombocythemia (ET) is a rare chronic myeloproliferative disorder. The quality of life ET patients may decrease as result ischemic and hemorrhagic complications unclear origin. Our goal was to characterize the hemostatic system in children with ET. We genotyped investigated blood samples from 20 prospective case series study using platelet aggregation, functional flow cytometry (FC) assay standard clotting assays. Three had JAK2V617F mutation, 4 mutations CALR 13 were...
Studies on platelet function in children older than neonatal period are few and their results controversial. The pediatric platelets were alternatively reported to be more active or less adults' ones. We compared the several age groups of adults evaluated when reaches status. study included 76 healthy 49 adult volunteers. Types activation used included: collagen-related peptide (CRP) PAR-1 activating SFLLRN; SFLLRN, PAR-4 AYPGKF adenosine diphosphate (ADP); ADP. parameters determined forward...
Abstract Immune thrombocytopenia (ITP) is believed to be associated with platelet function defects. However, their mechanisms are poorly understood, in particular regard differences between ITP phases, patient age, and therapy. We investigated bleeding children either persistent or chronic ITP, without romiplostim The study included 151 of whom 56 had disease duration less than 12 months (grouped together as acute/persistent) 95 were chronic. Samples 57 healthy used controls, while 5...
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Platelets perform numerous important functions not only in the process of normal functioning hemostatic system, but also other physiological processes, such as: vessel wall integrity regulation, wound healing, inflammatory response. Its malfunction can be found various diseases and conditions (including oncohematological disorders, solid tumors, diseases, sepsis, autoimmune disorders), is triggered by injury or medications lead to dangerous consequences, as bleeding thrombosis. However,...
Venous thromboembolism (VTE) is a frequent complication in children receiving treatment of cancer. VTE child with cancer increases duration and its cost, may reduce survival rates affects the quality life. Better understanding pathologic processes, causing cancer, will raise an effectiveness prophylactic approach.
In our country, the use of emicizumab in children with hemophilia A without inhibitors (HA) real-world clinical setting is limited and available only as few individual case reports. Our aim was to evaluate effectiveness safety prophylactic severe HA setting. We conducted a retrospective analysis medical records who had received at 9 centers based Russian Federation. assessed annualized bleeding rate (ABR), spontaneous (ASBR), joint (AJBR), for episodes that required additional treatment...
Inherited functional platelet disorders (IFPD) are very heterogeneous group of hemorrhagic diseases that difficult to diagnose. Prevalence IFPD in general population is probably underestimated. In most cases cause mild moderate bleeding symptoms everyday life but may result life-threating bleeding after trauma and surgical interventions. Rational diagnostic approach critical prevent these complications. Data on diagnostic algorithms as well benefits disadvantages of specific laboratory...
There are only limited data coming from isolated case reports regarding the real-world use of emicizumab for treatment children with hemophilia A and inhibitors (HAI) in Russia. The aim study was to evaluate efficacy safety prophylaxis severe HAI. Ethical approval not required since involved anonymized generalized retrospective obtained during routine clinical practice. We retrospectively analyzed medical records HAI who had been treated at 11 institutions located Russia, taking into...
The analysis of the results dalteparin sodium (Fragmin®) application for prevention and treatment thrombosis various biodisposition in 62 children has been given. average relative dose depending on age patient, effectiveness drug, s safety; need to select individually controlled doses evaluated.
Resolution by the Expert Council on use of Valoctocogene Roxaparvovec drug in patients with Hemophilia A Russia.
Methodological recommendations for surgical care in patients with hemophilia A receiving prophylactic therapy emicizumab. Recommendations of the expert group. Moscow, 2024.
In our country, experience in using simoctocog alfa children with hemophilia A (HA) without inhibitors real clinical practice is scarce and limited to few case reports pharmacokinetic analysis. Aim of the study: investigate pharmacokinetics HA practice. We carried out a retrospective analysis data from medical records treated at single healthcare center Russian Federation. For characterization alfa, we also measured following parameters Sysmex 2000 Hematology System: factor VIII activity...
The evolution of hemophilia treatment is rapidly developing. Both new factor replacement and non-factor therapy have appeared in recent years. One the most important problems relatively short half-life coagulation VIII (FVIII), with an average about 8–12 hours adults, ranging individual patients between 6 24 hours, even shorter younger children. This forces patients, especially children, to administer drug quite often (3–4 times a week), reducing quality life adherence treatment. appearance...