ABSTRACT In the present study, effect of arjunolic acid on testicular damage induced by intraperitoneal injection rats with 7 mg/kg cisplatin was studied. Cisplatin a significant reduction in weights, plasma testosterone, and reduced glutathione levels addition to elevation malondialdehyde gene expressions inducible nitric oxide synthase (iNOS), tumor necrosis factor‐α (TNF‐α), p38 mitogen‐activated protein kinase (MAPK) when compared control group ( p < 0.05). Lower tubular diameters...

Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. Studying the role played EGFR, CD10 Ki67 in recurrence of ameloblastoma. This study was carried out on 22 retrospective cases mandibular ameloblastoma from period Jan 2002 to 2008 with follow up until 2011 (3 8 years peroid). Archival materials were obtained pathology department, Mansoura university. Paraffin sections tumor tissue all submitted for routine H&E stains...

The objectives of present study were to examine the effects aluminum oxide (Al2O3) nanoparticles on myocardial functions, electrical activities, morphology, inflammation, redox state, and expression connexin 43 (Cx43) effect gallic acid (GA) these in a rat animal model. Forty male albino rats divided into 4 equal groups: control (normal) group; Al2O3 group, received (30 mg·kg(-1), i.p.) daily for 14 days; nano-alumina + GA (100 mg·kg(-1) orally once daily) days before administration. results...

Abstract Aim To investigate the impact of ischaemic pre‐conditioning ( I pre) and post‐conditioning post) on expression nuclear factor erythroid 2‐related 2 N rf2) gene its dependent genes, haem oxygenase‐1 HO ‐1) NADPH ‐quinone oxidoreductase‐1 NQO ‐1); inflammatory cytokines TNF ‐α, IL 1β ICAM ‐1; apoptotic markers such as caspase‐3 in renal ischaemia/reperfusion / R ) injury. Methods One hundred fifty male S prague D awley rats were classified into five groups (each consisted 30 rats):...

The polyunsaturated, ω-3 fatty acid, docosahexaenoic acid (DHA), claims diverse cytoprotective potentials, although via largely undefined triggers. Thus, we currently first tested the ability of DHA to ameliorate valproate (VPA)-evoked hepatotoxicity, modulate its anticonvulsant effects, then sought cellular and molecular basis such actions. Lastly, also verified whether may kinetically alter plasma levels/clearance rate VPA.VPA (500 mg/kg orally for 14 days in rats) evoked prominent...

The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) against cisplatin-induced nephrotoxicity has been reported, however, its efficacy in gonadotoxicity still not addressed. Herein, we investigated the effect BM-MSCs testicular toxicity and underlying mechanism action. Thirty male Sprague–Dawley rats were divided into a control group: injected with phosphate-buffered saline (PBS) intraperitoneal (ip), cisplatin single dose 7 mg/kg ip to induce received followed...

Acute kidney injury (AKI) is a complex clinical condition associated with significant morbidity and mortality lacking effective management. Ischemia-reperfusion (IRI) remains one of the leading causes AKI in native transplanted kidneys. The aim this study was to evaluate efficacy adipose-derived mesenchymal stem cells (ADSCs) prevention renal IRI rats. conducted on male Sprague-Dawley rats (n=72) weighing 250-300 g. Rats were randomly assigned three main groups: i) Sham-operated control...

Abstract Background Wnt/β-catenin pathway has an important role in hepatocarcinogenesis. It been involved progression, growth, epithelial mesenchymal transition and metastasis of hepatocellular carcinoma (HCC). This may represent a potential target for evolving treatment strategies. β-catenin gene (CTNNB1) identified as oncogene hepatocarcinogenesis previous trials to understand the pathogenesis HCC. study aimed spot light on Wnt/ β-Catenin CTNNB1 mutation HCC development its relation with...

Programmed Death-Ligand 1 (PD-L1) and Cytotoxic T Lymphocyte -Associated Antigen-4 (CTLA-4) are presently considered as prognostic markers therapeutic targets in numerous human malignancies. The goal of this study was to determine whether PD-L1 CTLA-4 might be used predict patients' survival Triple Negative Breast Cancer (TNBC). This retrospective cohort analyzed 100 primary TNBC cases that had surgical resection at the Oncology Center Mansoura University (OCMU), Faculty Medicine, Egypt....

Chaperonin-Containing Tailless complex polypeptide 6A (CCT6A) is considered one of the biomarkers that play a role in cancer initiation, progression and resistance to body defenses anti-cancer drugs. Its exact prognostic Ewing sarcoma (ES) remains uncertain. The aim this study assess immunohistochemical (IHC) expression CCT6A ES, relation its different clinicopathological parameters evaluate significance ES cases. This retrospective cohort included 35 cases diagnosed as at Oncology Center...

INTRODUCTION AND AIM OF WORK: Central nervous system (CNS) tumors represent a major public health problem, and their epidemiological data in Egypt have been rather incomplete except for some regional reports. There are no available frequency-based on CNS our locality. The objective of this study was to estimate the frequency east delta region, Egypt.The were collected during 8-year period from January 1999 December 2007 Pathology Department, Mansoura University, other referred pathology...

Cisplatin is an effective chemotherapeutic agent successfully used in the treatment of a wide range tumors. Nevertheless, nephrotoxicity has restricted its clinical use. Recent studies have strongly suggested that inflammatory mechanisms may play important role pathogenesis cisplatin nephrotoxicity. Celecoxib, selective cyclooxygenase-2 inhibitor as anti-inflammatory, therefore protective effect on cisplatin-induced renal injury.In present study, rats were injected intraperitoneally with...

Ischemic acute kidney injury (AKI) is usually accompanied by neuroinflammation-induced encephalopathy. However, the specific mechanism remains unclear. Toll-like receptors (TLR), specifically TLR-4 has been linked to ischemic reperfusion in different organs like kidney, brain and liver. Here, we induced an Sprague Dawley rats. All animals were evaluated using behavioral tests which revealed locomotor activity motor disturbances AKI group. The brains then examined immunostaining with ionized...

Acetaminophen (APAP, 4-hydroxyacetanilide) is the most common cause of acute liver failure in United States. In addition to exhibiting hepatotoxicity, APAP exerts a nephrotoxic effect may be independent induced damage. Toll-like receptors (TLRs) have been suggested as potential class novel therapeutic targets. The aim present study was investigate TLR-4 blocker TAK-242 prevention APAP-induced hepato-renal failure. Four groups C57BL mice were studied: Vehicle-treated/control (VEH),...

Chronic mastitis is a prolonged inflammatory breast disease, and little known about its etiology. We identified 85 cases 112 controls from 5 hospitals in Morocco Egypt. Cases were women with chronic (including periductal, lobular, granulomatous, lymphocytic, duct ectasia mastitis). Controls had benign including fibroadenoma, phyllodes, adenosis. Both groups histopathologically diagnosed patients 2008 to 2011, frequency-matched on age. Patient interviews elicited demographic, reproductive,...

PurposeCarbamazepine (CBZ)-evoked liver-injury is multifaceted and can be serious. Specific drug-antidote versus CBZ's hepatotoxicity has been absent. The effects of omega(ω)-3-FAs (Eicosapentaenoic acid, EPA, Docosahexaenoic DHA), on CBZ-toxicity, possibly-involved mechanisms, have remained unknown. Here, we investigated whether and, how then, two-ω-3-FAs (DHA/EPA) may alleviate hepatotoxicity, relieve the disrupted organelles liver, possibly alter CBZ-plasma levels.MethodsRats were treated...

Abstract Background High-grade serous ovarian carcinoma (HGSOC) is classified into four molecular subtypes; mesenchymal, proliferative, immunoreactive, and differentiated, with suggested different prognosis. Addressing the presence of histopathological immunohistochemical differences in HGSOC that parallel subtypes can help tailoring management protocol to improve therapeutic response patient outcome. Methods This retrospective study was conducted on 85 specimens for cases HGSOC. Cases were...

Idiopathic granulomatous mastitis (IGM) is a benign, frequently severe chronic inflammatory lesion of the breast. Its etiology remains unknown and reported cases vary in their presentation histologic findings with an optimal treatment algorithm yet to be described owing mainly disease's heterogeneity. IgG4-related disease (IgG4-RD) newly recognized systemic fibroinflammatory condition characterized by dense lymphoplasmacytic infiltrate many IgG4-positive plasma cells, storiform fibrosis,...

Glypican-3 (GPC3) is a member of the membrane-bound heparin sulfate proteoglycans. E-cadherin an adhesive receptor that believed to act as tumor suppressor gene. Many studies had investigated expressions in colorectal carcinoma (CRC) while only one study GPC3 expression CRC. This aims investigate GCP3 and mucinous (MA) non-mucinous adenocarcinoma (NMA) using manual tissue microarray technique. Tumor specimens are collected from 75 cases MC NMA who underwent radical surgery Jan 2007 2012 at...

Programmed death-ligand 1 (PD-L1) and human epidermal growth factor receptor 2 (HER2) are currently considered as prognostic markers therapeutic targets in many cancers. This study aims to evaluate immunohistochemical (IHC) expression of PD-L1 gastric cancer (GC) explore its role terms association with HER2 expression, different clinico-pathological variables, particular density cluster designation (CD)8 positivity tumor infiltrating lymphocytes (TILs) patients' disease-free overall survival...

To compare the effect of ischaemic preconditioning (Ipre) vs. postconditioning (Ipost) on renal ischaemia/reperfusion (I/R) injury in rats.In all, 120 male Sprague-Dawley rats were classified into four groups 30 each, designated sham, control, Ipre and Ipost. Renal function, including serum creatinine, blood urea nitrogen (BUN), creatinine clearance (CrCl), fractional Na excretion (FENa) histopathology measured at 2, 24 48 h after ischaemia. Markers lipid peroxidation (malondialdehyde, MDA),...